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In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads to longer lifespans in male mice. Klotho has various forms In their introduction, the researchers distinguish between the various forms of Klotho. The full mRNA...

The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice [1]. From East Asia to the clinic Ginkgolide B is a compound that can be extracted from Ginkgo biloba, an East Asian tree known as...

A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of how strongly genes affect our longevity has been asked before, and the emerging answer is not very much [1]. Most of the variation in human...

The Longevity Science Foundation (LSF) is thrilled to announce that it is organizing the Longevity Science Summit in Miami – the future hub of longevity sciences in the United States. The event will spotlight the latest advancements in healthy human longevity research and unite the local community for an evening of networking, collaboration, and celebration....

February might be the shortest month of the year, but it still has room for plenty of research and advancements. Here's what's happened over the last four weeks. Interviews Junevity Is Silencing RNA to Treat Obesity and Diabetes: Some longevity biotech companies fit neatly into one of the big buckets we have in this field,...

Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical...