Month: November 2023

In a recent publication in PLOS One, researchers have described the metabolic effects on running in generally healthy people. A lack of activity is a known risk factor This paper begins with warnings against sedentary behavior, citing one study reporting that it is responsible for approximately 1 out of 12 early deaths in the United...

The authors of a new review have analyzed randomized controlled trials that evaluated the impact of music therapy on the cognitive functions of people with Alzheimer’s [1]. Music to Alzheimer’s patients' ears Current pharmacology lacks a long-term method of effectively managing Alzheimer’s disease symptoms. Therefore, researchers have been looking into non-pharmacological therapies for treating these...

A new study reports a massive 33% increase in median lifespan in male genetically heterogeneous mice following prolonged isoleucine restriction [1]. Not all calories are created equal Caloric restriction is the most powerful life-extending intervention in rodents and primates [2], but the needed magnitude (about 30% fewer calories) is virtually impossible to maintain in humans...

In Nature Communications, researchers have explained how epigenetic drift and disorder are associated with shorter lifespans across species. When randomness is a problem We have previously reported on research demonstrating that epigenetic clocks are most likely to be measuring noise. This paper builds on that concept, citing previous research showing that this gradual epigenetic drift...

Due to Thanksgiving happening on our usual timeslot, the Journal Club returns on December 1st at 12 Eastern. The show will be livestreamed on the Lifespan.io Facebook channel and hosted by Dr. Oliver Medvedik. This month, we will be taking a look at a new paper relating to partial cellular reprogramming and includes Manuel Serrano...

A preprint study published on bioRxiv discusses how a species' maximum lifespan can be predicted by its epigenetics, showing that these differences are largely unaffected by interventions. Differences and similarities in mammals The researchers begin their paper with a note that bowhead whales live over a hundred times as long as shrews, even though these...