Category: News
CRISPR-Based Screen Reveals Possible Anti-Tau Mechanism
January 30, 2026
Using an ingenious CRISPR-based screening technique, scientists have found a protein that tags tau for degradation and is more strongly expressed in tau-resilient neurons [1]. Some neurons are more equal
Engineered Extracellular Vesicles Reduce Arrhythmia in Rats
January 29, 2026
In Nature Communications, researchers have described how small extracellular vesicles (sEVs) fused with plasma membrane proteins successfully treated heart arrhythmia in a rat model. Why do people need pacemakers? In
Shingles Vaccination Is Associated With Slower Aging
January 28, 2026
An analysis of over 3800 older adults found that shingles vaccination is associated with lower inflammation scores, slower epigenetic and transcriptomic aging, and a lower composite biological aging score [1].
Rapamycin Protects Immune Cells by Reducing DNA Damage
January 27, 2026
A new study from the Universities of Oxford and Nottingham has uncovered a potential new mechanism by which rapamycin counters immunosenescence. Rather than increasing autophagy or reducing protein synthesis, the
Using Placental Cells to Test Anti-Aging Compounds
January 26, 2026
Researchers publishing in Aging Cell have discovered that cells derived from the human placenta may be useful in estimating the effects of potential anti-aging treatments. A seemingly odd choice Of
Exercise Variety Is Associated With Lower Mortality Risk
January 23, 2026
A new study links exercise variety, defined as regularly engaging in several types of physical activity, to significantly lower all-cause mortality. Exercise amount matters as well, but the effect plateaus
How Senescent Astrocytes Don’t Support Neurons
January 22, 2026
Resesarchers have found that thrombospondin-1 (TSP-1), a compound that is critical in growing brain synapses, is secreted by normal astrocytes but not senescent ones. Senescence is harmful to the brain
The Impact of Childbearing Trajectories on Aging
January 21, 2026
The authors of a recent study investigated the relationship between reproduction (number and timing of children), aging, and survival. An analysis of seven distinct reproductive trajectories suggested that two groups,
Study Uncovers How Obesity Drives Chronic Inflammation
January 20, 2026
Scientists have discovered that obesity causes macrophages to ramp up mitochondrial DNA production, leading to more inflammation [1]. Obesity and inflammation Obesity is associated with multiple acute and chronic conditions,
A New Look at How Blood Stem Cells Age
January 19, 2026
In Aging Cell, four Japanese researchers have recently described the aging of the hematopoietic system, which is responsible for the creation of blood. A system that affects all the others
Vast Majority of Alzheimer’s Cases Attributable to One Gene
January 16, 2026
According to a new study, as many as 90% of Alzheimer’s cases can be attributed to “suboptimal” variants of the APOE gene. These results highlight the gene’s importance for Alzheimer’s
Longevity Advocacy in 2025: The Expert Roundup
January 15, 2026
The last installment in our end-of-year series of expert roundups might be the least flashy, but it is arguably no less important than the previous ones dedicated to longevity biotech
The Geroprotective Potential of Hormone Replacement Therapy
January 14, 2026
A recent review of literature investigated the risks and benefits of hormone replacement therapy. The authors point out that this approach could be used as a geroprotector to extend the
Geroscience in 2025: The Expert Roundup
January 13, 2026
2025 was a good year for geroscience, marked by rapid strides and critical milestones. Yet, the path wasn’t always smooth: progress in some areas lagged, research hit dead ends, and
A Protein That Exacerbates Heart Disease With Age
January 12, 2026
Researchers publishing in Aging Cell have found that Hevin, a protein found in the extracellular matrix that increases with age, leads to heart problems in older male mice. Inflammaging contributes
CRISPR-Based Screen Reveals Possible Anti-Tau Mechanism
January 30, 2026
Using an ingenious CRISPR-based screening technique, scientists have found a protein that tags tau for degradation and is more strongly expressed in tau-resilient neurons [1]. Some neurons are more equal than others The accumulation of tau protein fibrils in neurons is a hallmark of Alzheimer’s and
Engineered Extracellular Vesicles Reduce Arrhythmia in Rats
January 29, 2026
In Nature Communications, researchers have described how small extracellular vesicles (sEVs) fused with plasma membrane proteins successfully treated heart arrhythmia in a rat model. Why do people need pacemakers? In a healthy heart, the sinoatrial node (SAN) serves as a natural regulator, commanding the heart to
Shingles Vaccination Is Associated With Slower Aging
January 28, 2026
An analysis of over 3800 older adults found that shingles vaccination is associated with lower inflammation scores, slower epigenetic and transcriptomic aging, and a lower composite biological aging score [1]. Beneficial side effects Vaccines are developed to prevent specific diseases, such as polio, measles, hepatitis, and
Rapamycin Protects Immune Cells by Reducing DNA Damage
January 27, 2026
A new study from the Universities of Oxford and Nottingham has uncovered a potential new mechanism by which rapamycin counters immunosenescence. Rather than increasing autophagy or reducing protein synthesis, the effect appears to involve directly reducing DNA damage burden in immune cells [1]. How can this
Using Placental Cells to Test Anti-Aging Compounds
January 26, 2026
Researchers publishing in Aging Cell have discovered that cells derived from the human placenta may be useful in estimating the effects of potential anti-aging treatments. A seemingly odd choice Of all the organs in the body, the placenta may be the least concerning with regards to
Exercise Variety Is Associated With Lower Mortality Risk
January 23, 2026
A new study links exercise variety, defined as regularly engaging in several types of physical activity, to significantly lower all-cause mortality. Exercise amount matters as well, but the effect plateaus quickly [1]. How exactly is it good for you? “Exercise is good for you” is a
How Senescent Astrocytes Don’t Support Neurons
January 22, 2026
Resesarchers have found that thrombospondin-1 (TSP-1), a compound that is critical in growing brain synapses, is secreted by normal astrocytes but not senescent ones. Senescence is harmful to the brain It is well-known that cellular senescence causes brain damage and impairment. The SAMP8 mouse, which is
The Impact of Childbearing Trajectories on Aging
January 21, 2026
The authors of a recent study investigated the relationship between reproduction (number and timing of children), aging, and survival. An analysis of seven distinct reproductive trajectories suggested that two groups, women with the most live births and childless women, showed accelerated aging and increased mortality risk
Study Uncovers How Obesity Drives Chronic Inflammation
January 20, 2026
Scientists have discovered that obesity causes macrophages to ramp up mitochondrial DNA production, leading to more inflammation [1]. Obesity and inflammation Obesity is associated with multiple acute and chronic conditions, including cardiovascular disease and various metabolic disorders [2]. Increased sterile (not pathogen-induced) chronic inflammation is a
A New Look at How Blood Stem Cells Age
January 19, 2026
In Aging Cell, four Japanese researchers have recently described the aging of the hematopoietic system, which is responsible for the creation of blood. A system that affects all the others Aging and age-related diseases are often discussed in terms of hallmarks, such as senescence and genomic
Vast Majority of Alzheimer’s Cases Attributable to One Gene
January 16, 2026
According to a new study, as many as 90% of Alzheimer’s cases can be attributed to “suboptimal” variants of the APOE gene. These results highlight the gene’s importance for Alzheimer’s prevention [1]. Three alleles of APOE A growing amount of research links Alzheimer’s disease to the
Longevity Advocacy in 2025: The Expert Roundup
January 15, 2026
The last installment in our end-of-year series of expert roundups might be the least flashy, but it is arguably no less important than the previous ones dedicated to longevity biotech and geroscience. Public advocacy is a powerful lever. To quote Abraham Lincoln: “Public sentiment is everything.
The Geroprotective Potential of Hormone Replacement Therapy
January 14, 2026
A recent review of literature investigated the risks and benefits of hormone replacement therapy. The authors point out that this approach could be used as a geroprotector to extend the healthspan of women. However, the risk-benefit ratio should be individually evaluated. [1] Sex-specific aging trajectories Female
Geroscience in 2025: The Expert Roundup
January 13, 2026
2025 was a good year for geroscience, marked by rapid strides and critical milestones. Yet, the path wasn’t always smooth: progress in some areas lagged, research hit dead ends, and familiar bottlenecks persisted. Against this backdrop, we asked five prominent geroscientists to share their perspectives on
A Protein That Exacerbates Heart Disease With Age
January 12, 2026
Researchers publishing in Aging Cell have found that Hevin, a protein found in the extracellular matrix that increases with age, leads to heart problems in older male mice. Inflammaging contributes to heart disease The researchers begin by outlining the mechanisms involved in inflammaging, noting how it