Tag: Atherosclerosis

A new study suggests that increased protein intake, specifically of the amino acid leucine, can exacerbate atherosclerosis by inhibiting autophagy in macrophages [1]. Protein: friend or foe? The protein we get from food is indispensable, as it allows us to produce our own proteins, but the ideal amount of dietary protein remains an open question....

Cyclarity Therapeutics is developing an affordable, plaque-busting small molecule that may be the cure for the world's number one killer: cardiovascular disease. With human trials planned for this year, we decided that it was time to catch up with Cyclarity and its CEO of Scientific Affairs, Dr. Matthew O’Connor, to see how things were going....

A new study suggests that increases in LDL cholesterol and systolic blood pressure elevate the risk of atherosclerosis progression more in younger than in older people. The good news is that this can be reversed [1]. Creeping atherosclerosis Atherosclerosis is a major risk factor for cardiovascular disease [2], the primary cause of death in the...

In a new study published in Oxidative Medicine and Cellular Longevity, the researchers have shown that klotho ameliorates vascular calcification via increased autophagy [1]. ‘Rusty’ arteries Vascular calcification, the deposition of minerals in the cardiovascular system, is a complex pathological process that accompanies aging. It is associated with an increased risk of stroke, coronary artery...

Scientists have drastically improved various symptoms of atherosclerosis in mice by precisely targeting mitochondria with a plant-derived antioxidant [1]. Age-related and deadly Atherosclerosis, the accumulation of plaques on arterial walls, is one of the deadliest age-related diseases. Atherosclerotic plaques, which consist mostly of cholesterol and fat, can impede blood flow in the artery or burst,...

Underdog Pharmaceuticals (Now called Cyclarity Therapeautics) has just issued a press release announcing that UDP-003, a compound being studied for its effectiveness against oxidized cholesterol, has been given an Innovation Passport under the UK's Innovative Licensing and Access Pathway program. This is similar to the Fast Track designation given by the FDA in the United...