Tag: CAR-T

Scientists have found that the ratio between poly- and monounsaturated fatty acids affects the viability of T cells as well as both humoral and anti-tumor immunity [1]. The iron death Some fats are broadly recognized as healthy while others are considered unhealthy, but the reality might be more complicated than that. Poly- and monounsaturated fats...

A team of researchers has biologically engineered T cells with currently available Alzheimer's drugs in order to directly attack the characteristic amyloid plaques of Alzheimer's disease. Building on the current paradigm Most Alzheimer's treatments used in the clinic are -mabs, monoclonal antibodies that are designed to attack the amyloid beta plaques that accumulate in the...

In Nature Aging, researchers have published their finding that targeting urokinase plasminogen activator receptor (uPAR), a senescence-associated protein, restores gut function in mice. One way the gut lining ages Of all the tissues in the human body, the intestinal epithelium, which lines the gut, replaces its cells most quickly [1]. This self-renewal diminishes with aging...

Researchers publishing in Nature have reported a new advance in developing chimeric antigen receptor (CAR) T cells to fight solid tumors in the brain. A difficult endeavor CAR T cell-based therapies are normally discussed in the context of blood cancers, as getting them to effectively attack solid tumors has proven very difficult, despite intensive research...

By making NK cells insensitive to tumor-secreted TGF-β, scientists have improved their efficacy against this deadly hepatocellular carcinoma (HCC) [1]. Liver cancer and TGF-β Cancer cells, which are supposed to be vulnerable to the immune system, develop various defensive mechanisms to avoid detection and decrease immune cells’ fitness and viability. In solid tumors, the dense...

Scientists have demonstrated that CAR T cells can be employed against senescent intestinal stem cells, improving regeneration and ameliorating age-related symptoms such as “leaky gut” [1]. Cell-on-cell warfare Cellular senescence is a heterogeneous phenomenon in which cells stop dividing and malfunction, driving up inflammation. While senescent cells play a positive role in certain contexts, such...