Tag: Fertility

An investigation into transplanting human embryonic stem cells (hESC)-derived MSC-like cells (M cells) into the ovaries of cynomolgus monkeys suggests an extension of female reproductive span accompanied by a reduction in senescence-associated processes, such as inflammation, fibrosis, oxidative damage, and apoptosis [1]. Increasing healthspan by delaying menopause Aging of the female reproductive system precedes aging...

The researchers of a Nature Aging paper used multi-omics approaches to investigate cellular, molecular, and genetic drivers of human ovarian aging [1]. An early decline A decline in ovarian function occurs before a similar decline in other organs. Already in their mid-to-late thirties, women can experience symptoms such as fertility problems or increased frequency of...

A recent paper in the European Journal of Epidemiology reported that recurrent miscarriage and stillbirths are associated with the occurrence of dementia, but there was insufficient evidence to establish such a connection between infertility and dementia [1]. Sex-specific differences in dementia risk Dementia affects women more frequently than men. The authors of this paper discuss...

A recent paper has investigated the impact of polystyrene nanoplastics on the molecular processes of male reproductive tissues in mice [1]. Health risks of micro- and nanoplastics Microplastic and nanoplastic contamination is a worldwide public health concern for a good reason. Numerous research papers have associated microplastics with multiple health risks in the respiratory, immune,...

Experiments in mouse models show the efficacy and safety of mesenchymal stem cell transplantation in treating ovarian aging [1]. Mesenchymal stem cells as a therapy Mesenchymal stem cells (MSCs) are stem cells derived from mesodermal tissue, such as the umbilical cord, umbilical cord blood, the placenta, fat tissue, and bone marrow [2]. MSCs are a...

In a recent Pharmaceutical Research paper, the researchers explored the molecular processes through which the NAD+ precursors NMN and NR reversed ovarian aging in middle-aged rats [1]. Use it or lose it Female fertility decreases rather quickly in life. Aging leads to a decrease in the number and quality of oocytes, and fertilization success declines...