July 09, 2024
A new study describes a method of genetically modifying a fraction of tumor cells, programming them to self-destruct and take therapy-resistant cells with them [1]. Resisting the resistance Advanced solid tumors remain the main challenge for modern oncology. It’s hard to deliver a therapy to all of the cells in a tumor, and then the...
January 02, 2024
Scientists might have found support for the antagonistic pleiotropy theory of aging, which suggests that evolution selects some genetic traits that are associated with shorter lifespans because they also help us reproduce [1]. Evolution needs you to reproduce, not live long Shouldn’t evolution favor longer lifespans, so that animals have more time to procreate? To...
July 31, 2023
A paper published today in Nature Metabolism has described a method of genetically engineering cells to respond to electrical stimuli, allowing for on-demand gene expression. Finding a better trigger Despite its futuristic outlook, this line of research is built upon previous work. The idea of an implantable gene switch to command cells in order to...
July 19, 2023
Researchers have analyzed the activity of genes in the livers, kidneys, and brains of over a hundred mammals and found genes that are consistently associated with longevity [1]. The search for longevity-associated genes Between the shortest-living and the longest-living mammal, there is a more than 100-fold difference in lifespan. This natural difference may be key...
January 31, 2023
Scientists have shown that a longevity-associated variant of the BPIFB4 gene protects cardiovascular health, including when introduced by viral vectors [1]. All you need is LAV Among age-related pathologies, cardiovascular disease is the most prolific killer, claiming about 700,000 victims every year in the US alone and as many as 18 million worldwide. However, some...
January 04, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain extreme longevity [1]. Genetics can be friend or foe Centenarians are people who have lived for at least a century. Not only do these genetically...