Tag: Genomic Instability

Today, we bring you a selection of presentations from the annual conference organized by the Gerontological Society of America. Most of our savvy readers, if asked to name the biggest gerontology conference, would probably go with the venerable ARDD in Copenhagen or the new favorite, Hevolution Foundation’s Healthspan Summit in Riyadh. Yet, both pale in...

In a new study, the researchers administered human umbilical cord-derived mesenchymal stem cells (HUCMSCs) to aged mice and observed reduced degeneration in multiple organs, changes to microbial composition, metabolic alterations, improvements in behavior and ability, and reduced fearfulness [1]. Therapeutic potential Earlier this year, we reported on a clinical trial in which administering HUCMSCs reduced...

In Aging Cell, researchers have described the chemical ways in which excessive visceral fat causes oxidative stress and cellular senescence. Visceral fat is metabolically active Metabolic syndrome, a host of intertwined disorders that include obesity and cholesterol imbalance, is known to have multiple harmful effects that lead to decreased lifespan. These include a propensity towards...

Researchers have tested several combinations of ingredients with anti-aging properties. Those combinations, including a 12-ingredient formulation created by NOVOS, helped to reduce DNA damage and oxidative stress in human skin cells in cultures [1]. Fighting multiple Hallmarks of Aging at once Aging impacts multiple cellular processes, and these impacts can be assessed through biomarkers. The...

Steve Horvath, Vera Gorbunova, Alejandro Ocampo, and their team have used partial reprogramming to repair DNA damage in a mouse model. They published their findings in Frontiers in Aging. Building a path to rejuvenation Yamanaka Factors - Opportunities for RejuvenationDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram...

In a paper published on Saturday in Aging, researchers have described a method of activating the sirtuin SIRT6 to reduce DNA damage, reducing senescence and possibly treating arthritis. Sirtuins, genetic damage, and senescence Extensive previous research has found that SIRT6, a deacetylase that is dependent on NAD+, is instrumental in DNA repair [1] and naturally...