Tag: IGF-1

Researchers have found that altering a growth hormone receptor in the brain adipose tissue of aged male mice slows their mental aging and allows them to perform far better on cognitive tests. Growth signaling is not necessarily good The axis of growth hormone and insulin-like growth factor 1 (IGF-1) is well-known in aging, and the...

Research published in Aging Cell has discovered that castrated male mice show similarities to females in growth and lifespan [1]. It is widely known that women outlive men on average, but the biological reasons are still not fully understood. As it is challenging to experimentally test these reasons in humans, researchers turned to a special...

A team of Spanish researchers publishing in Aging have reported that they can delay reproductive senescence in female rats by stimulating the production of insulin growth factor 1 (IGF-1) through gene therapy. A well-studied approach IGF-1 is a well-known anti-inflammatory compound, having shown positive effects in human cells [1] and in mouse models [2]. In...

Researchers publishing in GeroScience have reported that the age-related decline in IGF-1 levels is associated with neurovascular aging [1]. IGF-1 and brain vasculature This paper begins with a discussion of neurovascular coupling (NVC) and its relationship to vascular dementia. Blood flow to the brain is extremely important, both to provide active brain regions with oxygen...

A new meta-analysis from Aging Cell has shown that both high and low levels of IGF-1 are related to mortality risk [1]. Insulin-like growth factor 1 (IGF-1) IGF-1 is one of the body’s major metabolic hormones. It can have effects similar to insulin, and it mediates the effects of growth hormone. IGF-1 has growth-promoting effects...

Scientists have managed to extend the lifespan of C. elegans nematode worms by as much as 135% by blocking an insulin-related pathway very late in life [1]. The long-lived mutants Back in the late 80s and early 90s, experiments with C. elegans, tiny nematode worms, became one of geroscience's first major successes. Scientists showed that...