Tag: iPSCs

In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice. A new era of organ replacement In their introduction, the researchers discuss the well-known problems with insulin injections to treat Type 1 diabetes: the sort of constant monitoring that is...

German scientists have created lab-grown “patches” of heart muscle tissue derived from pluripotent stem cells. Following a success with rhesus monkeys, they have obtained approval for a human trial [1]. Wear and tear As one of the most hard-working tissues in the body, the heart muscle is subject to incessant wear and tear due to...

Researchers are keeping a bank of induced pluripotent stem cells (iPSCs) derived from centenarians and their descendants. They describe the purpose of this bank and its uses in Aging Cell. A category of their own Centenarians don't merely live for a hundred years; they spend more time in good health (healthspan) than other people. This...

Scientists have successfully used heart muscle cells created from induced pluripotent stem cells to counter the deleterious effects of heart attack in non-human primates. Reprogrammed cells for heart regeneration Yamanaka Factors - Opportunities for RejuvenationDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic...

Instead of using cellular reprogramming to directly treat age-related diseases, a perspective published in Nature Communications focuses on the opposite: using reprogrammed cells to form aged tissues and organoids on which to conduct experiments. Why not just use donors? Obviously, there is no shortage of age-related tissues in the world, and tissue donors can and...

Researchers publishing in Aging have outlined how biochemical signals derived from created stem cells encourage blood vessels to form new branches in naturally aged mice. iPSCs, exosomes, and angiogenesis Exposure to the Yamanaka factors can cause ordinary cells to teturn to early stemness, from which they can divide into any other cell in the body....