Tag: Kidney

Researchers have found a new protein target for senescence-related kidney diseases and published their findings in Aging Cell. Kidney disease and fatty acid use Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit...

A recent study published in GeroScience has investigated whether or not a common index of metabolic syndrome can be applied to chronic kidney disease (CKD). A common metric of diabetes The triglyceride-glucose (TyG) index, which is calculated from fasting triglyceride and glucose, is used as a surrogate for insulin resistance [1], a key characteristic of...

  For the first time in history, scientists have been able to freeze, preserve, rewarm, and transplant rat kidneys with a new method of organ cryopreservation [1]. The rewarming problem Today, organ transplantation is severely limited by the fact that organs can only be preserved for a short time in near-freezing temperatures. Long-term cryopreservation of...

A cohort study that was published in BioMed Central by Dr. Alsayyari and colleagues examined fasting on acute kidney injury incidence [1]. Background Fasting during the month of Ramandan is a obligation in Islam with exceptions, such as for chronic illness that has a poor prognosis or is uncontrolled [2]. Our prior articles discuss the...

Scientists have shown that chloroquine, a well-known anti-malarial drug and the cousin of hydroxychloroquine, attenuates inflammation and fibrosis while significantly extending median and maximum lifespan in naturally aged rats [1]. Fighting malaria since 1934 Chloroquine (CQ) was developed back in 1934 as an anti-malarial treatment and as such has enjoyed significant success. Since 2020, an analog...

Researchers publishing in Aging Cell have discovered how and why oleuropein (OLP), a polyphenol derived from olives, ameliorates epigenetic kidney aging. Upregulation and downregulation Like nearly everything in biology, this specific part of kidney aging results from a chain of events. Here, the researchers show that DNA methyltransferases (DNMTs), which methylate and thereby epigenetically suppress...