Tag: Klotho

Researchers publishing in Biogerontology have tested multiple biomarkers in an effort to use them as proxies for aging, and some of their findings were surprising. A simple study with direct measurements Unlike other association studies that are used to evaluate biomarkers of aging, this study did not use data from a pre-existing biobank or related...

Researchers have explained in Nature Aging how klotho, a factor associated with longevity, improves the cognitive abilities of rhesus macaques. Moving on from mice This paper begins with a discussion of klotho and how it relates to aging. In mice, klotho has been found to improve cognitive function [1], even though systemic administration does not...

Research published in Heliyon has outlined the effects of F-Klb, a signaling molecule receptor that is released under metabolic stress, on the hearts of diabetic patients. Check out Cardio Diagnostics to learn more about their test kits. A protector that loses its effectiveness Fibroblast growth factor 21 (FGF21) is a regulator of metabolism that is...

In a new study published in Oxidative Medicine and Cellular Longevity, the researchers have shown that klotho ameliorates vascular calcification via increased autophagy [1]. ‘Rusty’ arteries Vascular calcification, the deposition of minerals in the cardiovascular system, is a complex pathological process that accompanies aging. It is associated with an increased risk of stroke, coronary artery...

Researchers publishing in Aging Cell have discovered how and why oleuropein (OLP), a polyphenol derived from olives, ameliorates epigenetic kidney aging. Upregulation and downregulation Like nearly everything in biology, this specific part of kidney aging results from a chain of events. Here, the researchers show that DNA methyltransferases (DNMTs), which methylate and thereby epigenetically suppress...

A recent study in The Journals of Gerontology, Series A has associated low klotho levels with mortality in Americans over the age of 40. Klotho and aging Prediction of mortality is a major interest of the aging field and the broader medical field. Epigenetic clocks, senescent cell accumulation, and telomere length have all received recent...