Tag: Metabolism

In Aging Cell, researchers have described how the enzyme Pck1, a core part of metabolic activity, is required for staving off senescence in fat (adipose) cells. The aging of fat With the decrease in metabolic activity that frequently occurs with aging, human beings often accumulate fat. This fat, itself, also ages; this paper describes it...

Researchers publishing in the Nature journal Cell Discovery have described how the age-related attenuation of a key metabolic axis causes human adipose-derived stem cells (hASCs) to lose functional capabilities. Pinpointing the loss of function This paper begins by highlighting a core problem of using self-derived (autologous) stem cells for treatments in older people: the cells...

In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around the body is subcutaneous fat. While this kind of fat is obviously not healthy to have in large amounts, it is not as immediately dangerous...

A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data. The researchers reported an association between tyrosine and shorter lifespan, with sex-specific differences. The results for phenylalanine were more inconsistent [1]. One by one Model animal research has shown that protein restriction can extend lifespan. However,...

In Aging Cell, researchers have outlined the relationship between Alzheimer's, increased pain sensitivity, and the enzyme LPCAT2. Pain is among the earliest signs The key characteristics of Alzheimer's disease, such as cognitive decline and brain deterioration, are very well-known [1]. However, other symptoms, such as pain sensitivity, may precede these key manifestations, providing an early...

Scientists have demonstrated that even two days on a Western-like high-fat diet reduce hippocampal glucose availability, which activates a subset of inhibitory neurons and causes memory problems in mice [1]. Is it OK to eat junk occasionally? Metabolic disease and obesity are known to harm cognitive function and have been linked to neurodegenerative diseases such...