Tag: Nanomedicine

In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the FGF18 protein with healthy cartilage and joints [1]. Problems with the gene responsible for FGF18 lead to osteoarthritis [2], and it has been found to...

In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go. Finding the right nanoparticle Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...

In a new study, a multi-prong treatment combined with a clever delivery method has shown promise against one of the deadliest cancers [1]. Lethal and barely treatable Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest types of cancer. It is rarely diagnosed early and very aggressive. It also responds poorly to treatment, primarily because...

Scientists have demonstrated that viral particles from a harmless plant virus can be used as an adjuvant therapy to prevent recurrence of disease and metastasis formation in several cancer models [1]. The challenge of keeping cancer at bay Medicine’s progress in treating cancer has been patchy: impressive with some cancers, dead-slow with others. For instance,...

Researchers have described how specialized nanoparticles, which deliver rapamycin and the antioxidant astaxanthin, restore macrophage balance and reduce inflammation in a mouse model of osteoarthritis. A matter of polarization Inflammation is a critical part of arthritis. Previous studies have found that inflammation of the membranes in joints (synovitis) strongly contributes to osteoarthritis [1]; in fact,...

Scientists have combined gallium nanoparticles with immunotherapy agents to deliver a decisive blow to colon cancer tumors in mice [1]. Cancer, you are terminated Most moviegoers are familiar with the liquid metal T-1000 from the Terminator series, and everyone knows about mercury, a liquid metal that is a very real poison. However, gallium, with a...