November 13, 2024
In a new study, researchers tested the impact of the senolytic drug ABT-263 on the reproductive systems of old female mice. ABT-263 treatment did not rescue age-related changes in hormonal levels, further depleted ovarian reserves, and didn’t improve most of the tested signs of reproductive aging [1]. Not created equal Aging doesn’t seem to affect...
February 07, 2024
Recent research published in Immunity and Ageing suggests that chitosan can be used as a potential treatment to alleviate some of the aging processes in ovaries [1]. Quickly declining fertility Mother Nature has imposed some tough challenges on human females. They need to make the decision about motherhood sooner rather than later, as research has...
February 15, 2023
In a paper published in Frontiers in Endocrinology, researchers have shown that transplanted young ovarian tissue improves the immune function of old recipient mice even if they are hormone-depleted [1]. Not just a reproductive matter Although women generally live longer than men, women spend almost half of their lives in poorer health due to reproductive...
November 07, 2022
A team of Spanish researchers publishing in Aging have reported that they can delay reproductive senescence in female rats by stimulating the production of insulin growth factor 1 (IGF-1) through gene therapy. A well-studied approach IGF-1 is a well-known anti-inflammatory compound, having shown positive effects in human cells [1] and in mouse models [2]. In...
July 12, 2022
Researchers have shown that resveratrol reverses several features of ovarian aging in mice while activating most sirtuins and boosting mitochondrial health [1]. Ovaries age first In many mammals, including humans, ovarian aging is premature compared to other systems. The reasons for this accelerated loss of function are not entirely clear, but they are known to...
June 21, 2022
Scientists have successfully treated ovarian aging in mice with compounds that target fibrosis and promote mitochondrial health [1]. Why do ovaries age faster? Ovarian aging is fascinating because one bodily system completely shuts down while the rest of the body is still in good health. Therefore, studying ovarian aging could provide us with valuable insights...