Tag: p16Ink4a

Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don't produce the senescence-related compound p16. A necessary evil Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...

A research paper published in Aging explored a link between breast cancer, hematopoietic cell transplants (HCTs), an increase in physical frailty, and cellular senescence. Treatment comes at a cost HCTs and breast cancer treatment are lifesaving procedures. However, chemotherapy in breast cancer sharply increases p16INK4a, a key biomarker of cellular senescence [1], and HCTs are...

Researchers publishing in Aging Cell have described how treating the increased senescent cell burden that comes with cigarette smoke exposure can repair some of the damage. Senescent cells and COPD Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which...

In a study recently published in Biochemistry and Biophysics Reports, researchers have shown that growing natural killer (NK) cells and re-introducing them back into the human bloodstream reduces senescence markers in a wide variety of immune cells. Peripheral blood mononuclear cells This research focuses on peripheral blood mononuclear cells (PBMCs), a category that includes T...

New senolytics data was released from Dr. James L. Kirkland’s Mayo Clinic lab and published in The Lancet [1]. Prior studies have shown that α-Klotho protein decreases with age in mice and humans [2,3]. It has also been demonstrated that mice that lack α-Klotho have shorter lifespans, cognitive impairment, sarcopenia, vascular dysfunction, osteopenia, cardiac hypertrophy...

The latest research published in Diabetes has implicated senescent cardiac stem cells as the link between diabetes and cardiovascular disease [1]. Why does diabetes increase the risk of cardiovascular disease? Type 2 diabetes mellitus is closely related to aging. Aging is a major risk factor for diabetes, and individuals with diabetes exhibit several characteristics of...