Tag: T Cells

Researchers have found that removing senescent cells makes it easier for mice to fight initial infections but harder for them to develop immune memory. Senescence and immunity Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...

In a paper published in Frontiers in Endocrinology, researchers have shown that transplanted young ovarian tissue improves the immune function of old recipient mice even if they are hormone-depleted [1]. Not just a reproductive matter Although women generally live longer than men, women spend almost half of their lives in poorer health due to reproductive...

A team of researchers from multiple Japanese universities has found a way to genetically enhance T cells against solid tumors, as published today in Nature Biomedical Engineering. A focus on signals This highly in-depth paper begins with a discussion of signaling in the response of chimeric antigen receptor (CAR) T cells, as good signals are...

New research published in Cancer Discovery has outlined a potential new method of using senescent cells to encourage the immune system to attack cancer [1]. Senescent cancer cells and immune clearance Cellular senescence is a stress response [2], and cancer cells within tumors undergo significant stress: they lose access to oxygen and nutrients, they divide...

Scientists have found that when T cells are activated by antigen-presenting cells, the activating cells donate chunks of their telomeres to the T cells, preventing senescence [1]. Imperfect protection Telomeres are sequences of TTAGGG repeats at the ends of our chromosomes that protect their integrity. Because of the way in which our somatic cells copy...

In Aging Cell, researchers have published the surprising and counterintuitive finding that older immune cells are able to kill cancer cells more quickly than their younger counterparts. The aging of CD8+ T cells The researchers introduce their subject by discussing CD8+ T cells in the context of aging. These cells form a major part of...