June 24, 2024
Scientists have identified a small molecule that upregulates telomerase reverse transcriptase (TERT) in multiple tissues, improving health and cognition in old mice. Telomere attrition and health Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet they consist of repetitions of...
February 21, 2022
In Nature Cell Biology, a team of researchers has presented a current review of telomeres and how they relate to aging, reflecting modern research into a decades-old topic. Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet they consist of...
January 21, 2022
Scientists publishing in Nature Aging have shown that telomerase reverse transcriptase slows neurodegeneration but not due to its telomere-building activity [1]. Chromosomes' bodyguards Why We Age: Telomere AttritionTelomeres are DNA regions located at the ends of a chromosome. Their normal length is 8-10 thousand base pairs, yet they consist of repetitions of a single sequence:...
November 08, 2021
Research published in Circulation has shown that mitochondrial, but not nuclear, telomerase reverse transcriptase (TERT) protects against damage caused by heart attacks in a murine model. A non-canonical role While TERT's name comes from its main function, the protection of telomere length in the cellular nucleus, the researchers make it clear that TERT has other...