Tag: Thymic Involution

A new study proposes a novel approach to fighting immune system decline caused by thymic involution: making the liver produce proteins that support T cell development and function [1]. Bringing back the Ts Immunosenescence, the gradual deterioration of the immune system, is a central aspect of aging. Research has tied it to increased cancer incidence,...

In a new paper, Yale scientists present encouraging data from an unprecedented human study of caloric restriction, a powerful anti-aging intervention [1]. Eat less, live more Despite all the might of today’s science, simple lifestyle choices are still the clearest option for living longer and healthier. These choices include being physically active, eating better, and...

A study published in Cell Reports shows how the thymus is stimulated to repair itself when dying thymocytes are depleted, paving the way towards novel methods of thymic regeneration. Cycles of involution, not a steady decline The researchers cite previous research showing that the thymus, despite being extremely sensitive to insults such as radiation and...

Publishing in Nature Communications' Cell Death Discovery, a team of Chinese researchers has discovered a reason for thymic involution, the age-related decline of the thymus. The thymus and its involution The thymus is a boot camp for T cells. Originating from bone marrow, T (for thymus) cells are chemically trained in the thymus, where they...

New research published in Biomacromolecules has successfully cultured thymic epithelial cells in vitro. A 3D biomaterial for thymic epithelial cells Tissue engineering and regenerative medicine attempts to regenerate tissues both in the lab and in vivo. While the fact that everyone experiences thymic involution should make it a prime target for regenerative medicine, very little...

In a review paper, a group of scientists highlight a new strategy that addresses the shortcomings of stem cell therapy by adding T cell progenitors to the graft [1]. HSCT has a problem Today, one of the few ways to alleviate immune system damage from chemotherapy and radiotherapy is a hematopoietic stem cell transplant (HSCT),...