Tag: Vascular Aging

Fecal microbiota transplantation from young mice to older mice improved multiple metabolic parameters and some hallmarks of aging, such as inflammation and telomere shortening [1]. Bringing back the balance Dysbiosis, an imbalance in the gut microbiome, is a newly recognized hallmark of aging [2]. Dysbiosis elevates the risk of many diseases, including cardiovascular diseases [3]....

Researchers have found that men and women have significant differences in how their brains' blood vessels change in Alzheimer's disease. The collapse of the blood-brain barrier Why We Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of...

A new publication in Nature Aging has explained a great deal about aging of the neurovascular system, showing where and how the brain's blood supply changes with aging in a mouse model. A branching network of blood vessels In the neurovascular system, arteries lead to arterioles, which then branch off into precapillary sphincters. These lead...

Researchers publishing in Aging have found that enlarged perivascular spaces (ePVS) in the brain are correlated with vascular disorders [1]. These spaces, which are part of the brain's glymphatic system, allow for the drainage of potentially dangerous metabolites such as beta amyloid [2]. A known biomarker of brain disorders As they become enlarged, perivascular spaces...

Researchers publishing in GeroScience have reported that the age-related decline in IGF-1 levels is associated with neurovascular aging [1]. IGF-1 and brain vasculature BrainThe brain is perhaps the most important organ in the body. While many organs are critical to our survival, the brain contains the self. It is responsible for personality and consciousness and...

A study published in Frontiers in Neurology has detailed how three well-known longevity-associated compounds affect vascular cognitive impairment (VCI) in a rat model. A rat model of a common human disease In bilateral common carotid artery occlusion (BCCAO), the arteries of rats are sutured to reduce blood flow. This mimics arterial occlusion in human beings...