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May 06, 2025
In Aging Cell, researchers have explained how transcription factor EB (TFEB) is related to cellular senescence and keeps stressed cells alive. Inactivated by mTOR Yesterday, we reported on TFEB's effects on proteostasis and how it has downstream functions on protein chaperones. This research, however, focuses on an somewhat different aspect of this transcription factor: its...
May 05, 2025
In Aging Cell, researchers have explored how transcription factor EB (TFEB) promotes proteostasis in a common aging model. Maintaining protein function Why We Age: Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of the root causes of age-related...
April 28, 2025
Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. A new approach to senescence Why We Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of...
April 24, 2025
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. When calcium goes where it doesn't belong Calcification is not the same as 'hardening' of blood vessel walls (atherosclerosis), which occurs due to plaque deposits. Calcification occurs when phosphates...
April 21, 2025
In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. Macrophages can impair blood vessel formation Heart attack and stroke are not the only problems caused by clogged and unusable blood vessels; when this occurs in...
April 16, 2025
Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk, finding a new potential target in the process. Putting -omics databases to work These researchers introduce their study by discussing genetic databases, which have previously been used to determine associations of specific genes with...
