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December 23, 2025
In Aging Cell, researchers have identified bone marrow stromal antigen 2 (BST2) as a key protein in age-related hearing loss in a mouse model. Neural myelination is necessary for function Demyelination, the loss of neurons’ protective sheaths, is known to be fundamental in multiple serious neurological disorders, including both amyotrophic lateral sclerosis (ALS) and multiple...
December 18, 2025
In Nature Aging, researchers have discovered how growth differentiation factor 3 (GDF3), a cytokine that increases with aging, is related to more inflammatory macrophages in older animals. Fat and inflammation We have recently reported on a potential treatment for visceral fat, as this kind of fat is known to generate health problems, including an increase...
December 15, 2025
In Aging, researchers have described how they removed visceral fat from older male mice by targeting the metabolic regulatory protein CD47. A key regulator of metabolism Visible fat carried around the body is subcutaneous fat. While this kind of fat is obviously not healthy to have in large amounts, it is not as immediately dangerous...
December 11, 2025
In Aging Cell, researchers have described how an age-related deficiency in another compound leads the antioxidant FoxO1 to contribute to bone deterioration in osteoporosis by siphoning from a bone-building pathway. A harmful antioxidant? Because they fight against harmful reactive oxygen species (ROS), antioxidants, both external and internal, are normally viewed as having positive effects against...
December 08, 2025
Researchers have discovered that extracellular vesicles (EVs) derived from the nasal mucosa provide significant regenerative benefits to tissues throughout the body, including the brain. A very regenerative tissue Previous work involving the transection of sizable portions of the nasal mucosa has found that this tissue grows back quickly and without scarring, even in older people...
November 27, 2025
In a preprint published in bioRxiv, Prof. Vadim Gladyshev and a team of researchers have used an artificial intelligence-based system to discover a wide variety of potential interventions, including a drug that significantly improves biomarkers of frailty in mice. Repurposing previous data Previous research efforts have created a massive dataset in the form of the...