Category: News
Spermidine for Cognitive Function in Flies, Mice, and Humans
April 21, 2021
Recently published research in Cell Reports provides a detailed account of dietary spermidine improving cognition and mitochondrial function in flies and mice, with some prospective human data to top it
B-cell Depletion Ameliorates Alzheimer’s in Mice
April 20, 2021
According to a new study, Alzheimer’s disease is connected to inflammaging, which causes B-cells to change their phenotype and hamper amyloid-β (Aβ) removal [1]. Following successful experiments in vivo, the
Increased Longevity and Overpopulation
April 20, 2021
Any discussion of rejuvenation biotechnology almost certainly includes the subject of overpopulation and the objection that medical advances that directly address the various processes of aging will lead to an overpopulated world. Such dire
Diet, Exercise Reduce Epigenetic Age in Human Clinical Trial
April 19, 2021
In a randomized, controlled human clinical trial, researchers have found that an eight-week program of diet, exercise, and meditation reduces epigenetic age by approximately two years in males between the
RNA Deep Sequencing Uncovers Parkinson’s Progression
April 15, 2021
A massive RNA sequencing effort has identified changes in microRNA associated with Parkinson’s. Some of the changes correlated with disease progression, holding out hope that they could be useful as
Rejuvenation is Not Immortality
April 15, 2021
When conducting science, it is crucially important to have clear, unambiguous definitions. These definitions must be firmly established to avoid confusion and misunderstandings and possibly to prevent people from going
The All-Party Parliamentary Group on UK Healthcare Equality
April 14, 2021
The UK All Party Parliamentary Group for Longevity (APPG) launched the Levelling Up Health initiative recently. The initiative aims to close the life expectancy gap, address health inequality in the
Hypoxia Reduces SASP Without Reducing Senescent Cell Burden
April 14, 2021
A new study in Molecular Cell has shown that the benefits of hypoxia may be derived from a suppression of the inflammatory SASP. Can less oxygen be a good thing?
Researchers Convert Astrocytes to Neurons in Vivo
April 13, 2021
Scientists have successfully reprogrammed astrocytes (a type of brain cell) into healthy neurons in the brains of living mice. This technique could potentially be used for replenishing the neuronal population
New CRISPR Technology Allows Turning Genes Off and On Again
April 12, 2021
A new technique allows researchers to turn epigenetic methylation off and back on again, thus allowing the silencing and unsilencing of certain genes. A CRISPR breakthrough CRISPR/Cas9 is a well-known
Researchers Claim Serum Albumin Increases Mouse Lifespan
April 9, 2021
Before we begin, it should be noted that this study was published on biorxiv, a pre-print website that hosts papers prior to peer review. Therefore the data should not be
A Non-Invasive Biomarker to Track Cellular Senescence
April 8, 2021
A lipid metabolite could serve as a novel biomarker to test the performance of senolytics, according to a new study [1]. Such a biomarker can be detected from blood or
Jim Mellon’s Funding of Longevity Projects
April 7, 2021
How does an idea that is too unconventional for mainstream channels get funded? Often, even venture capitalist firms are too risk-averse, and government funding agencies are too entrenched in the
The “Not in my Lifetime” argument
April 7, 2021
For much of human history, living up to a ripe old age was seen as a gift from the gods, an aberration, or just the product of sheer luck. Given
SenNet: The NIH Large-Scale Cellular Senescence Initiative
April 6, 2021
The National Institute of Health is going all-in on cellular senescence with its recently announced SenNet program. We asked two of the leading experts in aging research to weigh in
Spermidine for Cognitive Function in Flies, Mice, and Humans
April 21, 2021
Recently published research in Cell Reports provides a detailed account of dietary spermidine improving cognition and mitochondrial function in flies and mice, with some prospective human data to top it off. Spermidine and longevity Spermidine is known to decline with aging, and treatment with spermidine extends
B-cell Depletion Ameliorates Alzheimer’s in Mice
April 20, 2021
According to a new study, Alzheimer’s disease is connected to inflammaging, which causes B-cells to change their phenotype and hamper amyloid-β (Aβ) removal [1]. Following successful experiments in vivo, the scientists propose B cell depletion as a possible therapy. The darker side of B cells   Alzheimer’s
Increased Longevity and Overpopulation
April 20, 2021
Any discussion of rejuvenation biotechnology almost certainly includes the subject of overpopulation and the objection that medical advances that directly address the various processes of aging will lead to an overpopulated world. Such dire predictions are a common theme in many discussions involving advances in medicine that could increase human
Diet, Exercise Reduce Epigenetic Age in Human Clinical Trial
April 19, 2021
In a randomized, controlled human clinical trial, researchers have found that an eight-week program of diet, exercise, and meditation reduces epigenetic age by approximately two years in males between the ages of 50 and 72. A prescription for health For this study, the researchers used entirely
RNA Deep Sequencing Uncovers Parkinson’s Progression
April 15, 2021
A massive RNA sequencing effort has identified changes in microRNA associated with Parkinson’s. Some of the changes correlated with disease progression, holding out hope that they could be useful as prognostic or diagnostic biomarkers to help guide research and evaluate potential therapies. Pinning down Parkinson’s Although
Rejuvenation is Not Immortality
April 15, 2021
When conducting science, it is crucially important to have clear, unambiguous definitions. These definitions must be firmly established to avoid confusion and misunderstandings and possibly to prevent people from going around telling everyone that you’re working on something that you’re actually not. The I-word It’s not
The All-Party Parliamentary Group on UK Healthcare Equality
April 14, 2021
The UK All Party Parliamentary Group for Longevity (APPG) launched the Levelling Up Health initiative recently. The initiative aims to close the life expectancy gap, address health inequality in the UK, and foster a preventative approach to healthcare to support healthy longevity. It is estimated that
Hypoxia Reduces SASP Without Reducing Senescent Cell Burden
April 14, 2021
A new study in Molecular Cell has shown that the benefits of hypoxia may be derived from a suppression of the inflammatory SASP. Can less oxygen be a good thing? Cell cultures are typically maintained in conditions close to atmospheric oxygen levels, but these are much
Researchers Convert Astrocytes to Neurons in Vivo
April 13, 2021
Scientists have successfully reprogrammed astrocytes (a type of brain cell) into healthy neurons in the brains of living mice. This technique could potentially be used for replenishing the neuronal population in people suffering from brain damage and age-related cognitive decline [1]. Cellular fate is not sealed
New CRISPR Technology Allows Turning Genes Off and On Again
April 12, 2021
A new technique allows researchers to turn epigenetic methylation off and back on again, thus allowing the silencing and unsilencing of certain genes. A CRISPR breakthrough CRISPR/Cas9 is a well-known technology for editing the genome, but its potential for epigenetic editing had never been previously explored.
Researchers Claim Serum Albumin Increases Mouse Lifespan
April 9, 2021
Before we begin, it should be noted that this study was published on biorxiv, a pre-print website that hosts papers prior to peer review. Therefore the data should not be regarded as conclusive or accurate until it has been subject to the peer review process and
A Non-Invasive Biomarker to Track Cellular Senescence
April 8, 2021
A lipid metabolite could serve as a novel biomarker to test the performance of senolytics, according to a new study [1]. Such a biomarker can be detected from blood or urine, allowing for non-invasive testing, and experiments have shown that it plays a functional role in
Jim Mellon’s Funding of Longevity Projects
April 7, 2021
How does an idea that is too unconventional for mainstream channels get funded? Often, even venture capitalist firms are too risk-averse, and government funding agencies are too entrenched in the status quo, to consider the most revolutionary ideas. Commonly given advice in the start-up world tells
The “Not in my Lifetime” argument
April 7, 2021
For much of human history, living up to a ripe old age was seen as a gift from the gods, an aberration, or just the product of sheer luck. Given that up to the beginning of the twentieth century, many of us succumbed to disease at
SenNet: The NIH Large-Scale Cellular Senescence Initiative
April 6, 2021
The National Institute of Health is going all-in on cellular senescence with its recently announced SenNet program. We asked two of the leading experts in aging research to weigh in on this initiative. The NIH takes notice Cellular senescence has been at the forefront of longevity