The Timing of Meals Matters for Biological Aging
A recent study investigated a connection between the timing of meals and the rate of biological aging. These findings suggest that later timing of the first and last meals is
Creating a Future Where Everyone Can Live Longer, Healthier Lives
Building A Global Ecosystem To Advance Research That Will Overcome Age-Related Disease And Extend Healthy Human Lifespan
join the Community
Help us drive the science and systems that support longer, healthier lives for all.
By joining the Lifespan community, you’ll be part of a growing movement working to advance cutting-edge research, shape public understanding, and build the foundations for lasting impact in the field of longevity science. Whether you’re a scientist, supporter, or simply care about the future of human health, your voice helps move the field forward.
Our Mission
We Are Building a Future Free of Age-Related Disease
Lifespan Research Institute is focused on strategically driving forward science to extend healthy human lifespan through advocacy, ecosystem building, and direct support of cutting edge research into the root causes of aging.
Age-related diseases such as Alzheimer’s, heart disease, and cancer, cause untold harm, both in terms of personal suffering and socio-economic effects. Like treating the trunk of a tree as opposed to its various branches, it is a much more effective strategy to treat age-related maladies by addressing the process that is at the heart of them all, the aging process itself.
Our Four Pillars
Our Research
We conduct targeted scientific research with the explicit goal of accelerating the development of therapies that address the root causes of aging.
Education Opportunities
Our educational programs offer several options for students interested in engaging with our mission of preventing age-related diseases.
Longevity Investor Network
Through our investor network, we catalyze private investment in biotechnology companies developing interventions that target the root mechanisms of aging.
Public Advocacy
We make the ground fertile for the entire field through advocacy initiatives that foster societal change, increasing available public and private funding for aging research.
Addressing the Root Causes of Aging is a Much Better Way to Fight Disease
Healthy Life Expectancy and Total Life Expectancy Gained
Cure Cancer
- Healthy Life: 2.5 yrs
- Total Life: 3 yrs
Cure Heart Disease
- Healthy Life: 4 yrs
- Total Life: 5 yrs
Improve Biological Aging
- Healthy Life: 25+ yrs
- Total Life: 25+ yrs
Latest From Our News Outlet
APOE4 Increases Neurons’ Excitability Before Symptoms Appear
The pro-Alzheimer’s allele APOE4 makes hippocampal neurons in mice smaller and hyperexcitable. This effect, which resembles epilepsy and accelerated aging, can be mitigated by manipulating a neuronal protein [1]. Before
A Target for Ameliorating Post-Operative Delirium
Researchers have discovered a potential treatment for post-operative delirium, which accelerates cognitive decline in older people. A common problem with long-term effects Roughly a quarter of older people suffer from
Research Highlights & Outreach
Advancing scientific understanding and community engagement in aging and longevity.
Research
New Paper from LRI’s Sharma Lab on Senescent Cell Targeting
This study identifies an aberrant localization of the protein LAMP1 on the surface of senescent cells. Cells that presented LAMP1 on the surface showed clear signs of having a senescent/aged phenotype. The team was able to target LAMP1 on the surface of senescent cells to eliminate them.
Volunteers
LRI Needs Volunteers for Aging and Longevity Study.
Lifespan Research Institute is seeking volunteers for blood donations. Your participation will help advance our understanding of the immune system and mitochondrial biology in aging.
outreach
The Promise of Digital Biomarkers to Accelerate Aging Research
Keith Comito presents at the Longevity Biomarker Summit, organized by Rejuve.Ai and hosted at Infinita City, Roatán, on February 6-8, 2026. In this talk, Keith describes emerging technologies capable of developing fast, cheap, and reliable digital biomarkers utilizing voice, face, and gait analysis, based on easy-to-collect audio and video data.
outreach
Keith Comito Moderates Panel on the Geopolitics of Aging Research at the A4LI DC Summit
At the A4LI DC Summit Event, Keith Comito moderated the panel “Aging Populations: A Geopolitical Perspective” with Niklas Anzinger, Mac Davis, and Jasmine Smith, exploring how global demographic shifts toward aging populations impact societies, economies, and international cooperation.
Latest LRI News
Lifespan Research Institute Launches Public Longevity Group
[Mountain View, September 17, 2025] — Lifespan Research Institute (LRI) today announced the launch of the Public Longevity Group (PLG), a new initiative focused on bridging the cultural gap between
Lifespan Alliance Launch & New Leadership at LRI
Mountain View, California — Lifespan Research Institute, a nonprofit leader in longevity science and advocacy, announces the launch of the Lifespan Alliance, a sponsorship initiative uniting mission-driven companies and visionary
Gamma Delta T Cells Show Promise Against Cellular Senescence
Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis [1].
