By joining the Lifespan community, you’ll be part of a growing movement working to advance cutting-edge research, shape public understanding, and build the foundations for lasting impact in the field of longevity science. Whether you’re a scientist, supporter, or simply care about the future of human health, your voice helps move the field forward.
Lifespan Research Institute is focused on strategically driving forward science to extend healthy human lifespan through advocacy, ecosystem building, and direct support of cutting edge research into the root causes of aging.
Age-related diseases such as Alzheimer’s, heart disease, and cancer, cause untold harm, both in terms of personal suffering and socio-economic effects. Like treating the trunk of a tree as opposed to its various branches, it is a much more effective strategy to treat age-related maladies by addressing the process that is at the heart of them all, the aging process itself.
We support targeted scientific research with the explicit goal of accelerating the development of therapies that address the root causes of aging.
Our educational programs offer several options for students interested in engaging with our mission of preventing age-related diseases.
Through our investor network, we catalyze private investment in biotechnology companies developing interventions that target the root mechanisms of aging.
We make the ground fertile for the entire field through advocacy initiatives that foster societal change, increasing available public and private funding for aging research.
A new study has found that increased production of serotonin by neurons in a particular brain region inhibits dopamine production and willingness to move, causing loss of activity. Killing serotonin-producing
Researchers have found that HDAC7 bridges together GSK3β and hyperphosphorylated tau protein (hTau) in neurons, which may spur Alzheimer’s disease. Getting rid of HDAC7 in hTau model mice ameliorated their
A recent study showed that a treatment with the short peptide elamipretide reversed multiple signs of age-related decline in oocyte quality in mice and in human oocytes in vitro [1].
Advancing scientific understanding and community engagement in aging and longevity.
LRI CEO Keith Comito recently published a preprint of a forthcoming book chapter analysing cultural narratives and contemporary polling data to illustrate that broad public support exists for increased healthspan, and even radical lifespan gains, provided they are equitable and grounded in credible science. These findings challenge the assumption that advocacy must downplay longevity goals for wider acceptance.
This study identifies an aberrant localization of the protein LAMP1 on the surface of senescent cells. Cells that presented LAMP1 on the surface showed clear signs of having a senescent/aged phenotype. The team was able to target LAMP1 on the surface of senescent cells to eliminate them.
Keith Comito presents at the Longevity Biomarker Summit, organized by Rejuve.Ai and hosted at Infinita City, Roatán, on February 6-8, 2026. In this talk, Keith describes emerging technologies capable of developing fast, cheap, and reliable digital biomarkers utilizing voice, face, and gait analysis, based on easy-to-collect audio and video data.
At the A4LI DC Summit Event, Keith Comito moderated the panel “Aging Populations: A Geopolitical Perspective” with Niklas Anzinger, Mac Davis, and Jasmine Smith, exploring how global demographic shifts toward aging populations impact societies, economies, and international cooperation.
Researchers are developing biomedical repair therapies to address multiple age-related diseases at once, yet they are forced to put them through regulatory pathways built for single-disease drugs. The result is
Worldwide healthcare faces an unsustainable situation. We spend trillions managing the late-stage effects of biological aging, yet routinely overlook the underlying causes that drive them. Driven by an aging society,
The Longevity Investor Network (LIN) was created to help bridge the gap between promising longevity startups and the investors capable of helping them scale. Through curated monthly pitch sessions, educational
