Category: News
The Heterogeneity of Senescent Cells
September 18, 2019
Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells
Longevity, Aging, and Life Expectancy
September 17, 2019
Dr. S. Jay Olshansky is a Professor in the School of Public Health at the University of Illinois at Chicago, Research Associate at the Center on Aging at the University
David Sinclair on NMN and Epigenetics
September 10, 2019
Dr. David Sinclair, a Professor of Genetics at Harvard Medical School, is one of the most well-known researchers in the field of rejuvenation, and his lab is the beneficiary of
Kevin Strange Teaches Us About MSI-1436
September 9, 2019
Dr. Kevin Strange is the CEO and co-founder of Novo Biosciences, a biotechnology company focused on regenerating the heart and other organs. We recently had the opportunity to interview him
Study Results Suggest Human Aging Can Be Reversed
September 6, 2019
A small clinical trial, which was conducted by a team of researchers led by Dr. Greg Fahy, has shown for the first time in humans that reversing biological age may
Telomerase Expression Reduces Senescence and Cancer Risk
September 4, 2019
A joint study by researchers at the National Institutes of Health (NIH) and the University of Maryland (UMD) has revealed a previously undocumented protective function of the telomerase enzyme. Telomerase
Brain, Liver and Muscle Rejuvenated by Calibrating Old Blood
September 3, 2019
Age-related changes to the signals sent and received by our cells travelling via the bloodstream (altered intercellular communication) are thought to be one of the reasons we age. A team
A New Era Beckons as First Drug Is Created by AI
September 2, 2019
Insilico Medicine has achieved a world first by successfully designing, synthesizing, and validating a new drug from the ground up and taking just 46 days to do so. It achieved
Sarah Constantin on the Daphnia of Daphnia Labs
August 9, 2019
We recently had the opportunity to catch up with Sarah Constantin, one of the founders of the new biotech startup company Daphnia Labs. The company is developing a new platform
Heart Inflammation Causes a Shift in Cell Fate Distribution
August 7, 2019
A study on animals with autoimmune myocarditis was recently released in the journal Cell Reports [1], showing the impact of heart inflammation on the types of immune cell that are
Cellular Reprogramming Reverses Age-Related Vision Loss
August 6, 2019
Today, we want to draw attention to a new study that shows how partial cellular reprogramming was able to reverse cellular aging and address age- and injury-induced blindness in mice.
Population Prospects 2019 and Life Extension
August 5, 2019
A common concern about life extension is overpopulation, the idea that there are too many people in the world. Are we really headed for a global overpopulation meltdown, as some
An Interview With Dr. Daniel Ives of Shift Bioscience
August 2, 2019
Shift Bioscience is a company aiming to solve the problem of mitochondrial dysfunction, one of the hallmarks of aging, by repairing the aging mitochondria in our cells so that they
Rejuvenation Roundup July 2019
August 1, 2019
Last month was arguably the busiest of all for everybody on the LEAF team, given that our second NYC conference was taking place—and, by the way, it was a great
George Church Is Creating Therapies for Dogs
July 23, 2019
Recently, we had the opportunity to interview Professor George Church, a well-known geneticist and rejuvenation expert. Prof. Church’s company, Rejuvenate Bio, will be launching a clinical trial to test a
The Heterogeneity of Senescent Cells
September 18, 2019
Cellular senescence, discovered in 1961 by Leonard Hayflick and Paul Moorhead, is a state in which cells no longer perform their functions, instead emitting harmful chemicals that turn other cells senescent. Senescence is primarily caused by telomere shortening and DNA damage, and senescent cells are known
Longevity, Aging, and Life Expectancy
September 17, 2019
Dr. S. Jay Olshansky is a Professor in the School of Public Health at the University of Illinois at Chicago, Research Associate at the Center on Aging at the University of Chicago and at the London School of Hygiene and Tropical Medicine, and Chief Scientist at
David Sinclair on NMN and Epigenetics
September 10, 2019
Dr. David Sinclair, a Professor of Genetics at Harvard Medical School, is one of the most well-known researchers in the field of rejuvenation, and his lab is the beneficiary of a successful Lifespan.io campaign. Today, Dr. Sinclair is releasing his book on Amazon, “Lifespan: Why We
Kevin Strange Teaches Us About MSI-1436
September 9, 2019
Dr. Kevin Strange is the CEO and co-founder of Novo Biosciences, a biotechnology company focused on regenerating the heart and other organs. We recently had the opportunity to interview him about MSI-1436 (trodusquemine), a compound that promotes regeneration in multiple animal models. What, if anything, happens
Study Results Suggest Human Aging Can Be Reversed
September 6, 2019
A small clinical trial, which was conducted by a team of researchers led by Dr. Greg Fahy, has shown for the first time in humans that reversing biological age may be possible. The results of TRIIM are in The researchers spent a year running the Thymus
Telomerase Expression Reduces Senescence and Cancer Risk
September 4, 2019
A joint study by researchers at the National Institutes of Health (NIH) and the University of Maryland (UMD) has revealed a previously undocumented protective function of the telomerase enzyme. Telomerase is used by somatic cells too It was thought for a long time that telomerase is
Brain, Liver and Muscle Rejuvenated by Calibrating Old Blood
September 3, 2019
Age-related changes to the signals sent and received by our cells travelling via the bloodstream (altered intercellular communication) are thought to be one of the reasons we age. A team of researchers, including Drs. Irina and Michael Conboy, has published the results of a new study
A New Era Beckons as First Drug Is Created by AI
September 2, 2019
Insilico Medicine has achieved a world first by successfully designing, synthesizing, and validating a new drug from the ground up and taking just 46 days to do so. It achieved this impressive feat using AI. This is the first time that AI has been used to
Sarah Constantin on the Daphnia of Daphnia Labs
August 9, 2019
We recently had the opportunity to catch up with Sarah Constantin, one of the founders of the new biotech startup company Daphnia Labs. The company is developing a new platform for the discovery of geroprotective drugs: in vivo phenotypic screens in model organisms. The company plans
Heart Inflammation Causes a Shift in Cell Fate Distribution
August 7, 2019
A study on animals with autoimmune myocarditis was recently released in the journal Cell Reports [1], showing the impact of heart inflammation on the types of immune cell that are formed in the heart. This could have a significant impact on our understanding of cardiac aging.
Cellular Reprogramming Reverses Age-Related Vision Loss
August 6, 2019
Today, we want to draw attention to a new study that shows how partial cellular reprogramming was able to reverse cellular aging and address age- and injury-induced blindness in mice. Epigenetic alterations One of the proposed reasons we age is the changes to gene expression that
Population Prospects 2019 and Life Extension
August 5, 2019
A common concern about life extension is overpopulation, the idea that there are too many people in the world. Are we really headed for a global overpopulation meltdown, as some people believe? The United Nations’ World Population Prospects 2019 report suggests that while the global population
An Interview With Dr. Daniel Ives of Shift Bioscience
August 2, 2019
Shift Bioscience is a company aiming to solve the problem of mitochondrial dysfunction, one of the hallmarks of aging, by repairing the aging mitochondria in our cells so that they work as if they were younger. Mitochondrial dysfunction is at the heart of aging The mitochondria
Rejuvenation Roundup July 2019
August 1, 2019
Last month was arguably the busiest of all for everybody on the LEAF team, given that our second NYC conference was taking place—and, by the way, it was a great success! Today, we’re offering a detailed account of the conference as well as all that has
George Church Is Creating Therapies for Dogs
July 23, 2019
Recently, we had the opportunity to interview Professor George Church, a well-known geneticist and rejuvenation expert. Prof. Church’s company, Rejuvenate Bio, will be launching a clinical trial to test a rejuvenation therapy in dogs this fall. In your recent paper on enabling large-scale genome editing, you