Category: News
Samumed Begins Phase 3 Trial for Knee Osteoarthritis
May 7, 2019
San Diego-based biotechnology company Samumed has recently announced that it will be moving to phase 3 clinical trials of its drug lorecivivint (SM04690) for the treatment of knee osteoarthritis. What
Bone Marrow Transplants Increase Healthy Lifespan in Mice
May 6, 2019
Stem cell transplants have been of great interest to aging researchers, and, in a new study, they have successfully increased mouse lifespan by using stem cell therapy. While this has
A New Database for Senescent Cells
May 3, 2019
Today, we want to spotlight a new publication that charts the senescence-associated secretory phenotype (SASP), which consists of the various secreted signals given out by senescent cells during aging. Senescent
Reversal of Two Advanced Glycation End Products Achieved
May 2, 2019
Today, we want to highlight a new study that shows, for the first time, that established AGEs can be reversed via therapeutic intervention. What are AGEs? Advanced glycation end products
Success at the Xprize Foundation
May 1, 2019
On April 29th and 30th, the XPRIZE Foundation hosted an event at its headquarters in Culver City, California that could have a profound effect on the evolving landscape of biorejuvenation
NMN Improves Cognitive Function in Aged Mice
April 30, 2019
Researchers have tested nicotinamide mononucleotide on aged mice to see if it can help reverse age-related cognitive decline by improving blood flow in the brain. The brain is a hungry
One Step Closer to Artifical Lymph Nodes
April 25, 2019
Scientists from Johns Hopkins Medicine have reported the successful creation of a special type of gel that mimics the lymph nodes in our bodies. This gel recruits and multiplies T
Jerry Shay on Telomere Measurements
April 17, 2019
Professor Jerry Shay of the Shay/Wright lab is perhaps most well-known for his research on telomeres and telomerase and their relation to cancer and aging. He has been instrumental in
Joan Mannick of resTORbio Discusses Rapalogs
April 16, 2019
Rapamycin is a promising anti-aging therapeutic derived from a bacterium that was first found on Easter Island (it’s named for Rapa Nui, the official name of Easter Island). It inhibits
Kelsey Moody & Huda Suliman On Rejuvenation
April 11, 2019
At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages
Reversing Cognitive Decline by Blocking a Single Protein
April 9, 2019
A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit,
Senolytics Improve Recovery Following a Heart Attack
April 8, 2019
In a new study, researchers show that the presence of senescent cells is an important contributor to aging of the cardiovascular system, particularly the heart [1]. Senescent cells and senolytics
Yuri Deigin On Yamanaka Factors
April 5, 2019
At the Undoing Aging 2019 conference, we had the opportunity to interview Yuri Deigin, the CEO of Youthereum Genetics. His company is developing therapies that focus on OSKM, the Yamanaka
Reversing Cellular Aging with Prof. Vittorio Sebastiano
April 4, 2019
We recently attended the Undoing Aging Conference in Berlin and had the opportunity to interview Professor Vittorio Sebastiano of Turn.Bio, a company developing partial cellular reprogramming techniques to reverse cellular
An Interview with Dr. Judith Campisi
April 3, 2019
At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages
Samumed Begins Phase 3 Trial for Knee Osteoarthritis
May 7, 2019
San Diego-based biotechnology company Samumed has recently announced that it will be moving to phase 3 clinical trials of its drug lorecivivint (SM04690) for the treatment of knee osteoarthritis. What is osteoarthritis? Osteoarthritis is the most common form of arthritis in the knee and a leading
Bone Marrow Transplants Increase Healthy Lifespan in Mice
May 6, 2019
Stem cell transplants have been of great interest to aging researchers, and, in a new study, they have successfully increased mouse lifespan by using stem cell therapy. While this has been previously achieved, this experiment was more refined than older studies and sheds new light on
A New Database for Senescent Cells
May 3, 2019
Today, we want to spotlight a new publication that charts the senescence-associated secretory phenotype (SASP), which consists of the various secreted signals given out by senescent cells during aging. Senescent cells and the SASP As we get older, an increasing number of our cells enter into
Reversal of Two Advanced Glycation End Products Achieved
May 2, 2019
Today, we want to highlight a new study that shows, for the first time, that established AGEs can be reversed via therapeutic intervention. What are AGEs? Advanced glycation end products (AGEs) are harmful compounds that are created when proteins or fats combine with sugars in the
Success at the Xprize Foundation
May 1, 2019
On April 29th and 30th, the XPRIZE Foundation hosted an event at its headquarters in Culver City, California that could have a profound effect on the evolving landscape of biorejuvenation research: the Future of Longevity Impact Roadmap Lab. For those unfamiliar, the XPRIZE Foundation is famous
NMN Improves Cognitive Function in Aged Mice
April 30, 2019
Researchers have tested nicotinamide mononucleotide on aged mice to see if it can help reverse age-related cognitive decline by improving blood flow in the brain. The brain is a hungry organ Healthy brain function relies on efficient cerebral blood flow (CBF) to wash away harmful waste
One Step Closer to Artifical Lymph Nodes
April 25, 2019
Scientists from Johns Hopkins Medicine have reported the successful creation of a special type of gel that mimics the lymph nodes in our bodies. This gel recruits and multiplies T cells just like actual lymph nodes do, so it could help in the fight against cancer
Jerry Shay on Telomere Measurements
April 17, 2019
Professor Jerry Shay of the Shay/Wright lab is perhaps most well-known for his research on telomeres and telomerase and their relation to cancer and aging. He has been instrumental in the development of telomerase inhibitors, which turn off the expression of telomerase in cancer cells; this
Joan Mannick of resTORbio Discusses Rapalogs
April 16, 2019
Rapamycin is a promising anti-aging therapeutic derived from a bacterium that was first found on Easter Island (it’s named for Rapa Nui, the official name of Easter Island). It inhibits mTOR (mechanistic target of rapamycin), thus inhibiting the immune system response that would, in some cases,
Kelsey Moody & Huda Suliman On Rejuvenation
April 11, 2019
At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages of aging and may one day lead to a future without the diseases of aging. We
Reversing Cognitive Decline by Blocking a Single Protein
April 9, 2019
A team of Stanford researchers led by Professor Wyss-Coray set out to find out which genes were linked to age-related cognitive decline. Not only did the researchers find the culprit, they were able to reverse cognitive decline and rejuvenate aged mouse brains. Searching for the cause
Senolytics Improve Recovery Following a Heart Attack
April 8, 2019
In a new study, researchers show that the presence of senescent cells is an important contributor to aging of the cardiovascular system, particularly the heart [1]. Senescent cells and senolytics As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent
Yuri Deigin On Yamanaka Factors
April 5, 2019
At the Undoing Aging 2019 conference, we had the opportunity to interview Yuri Deigin, the CEO of Youthereum Genetics. His company is developing therapies that focus on OSKM, the Yamanaka factors known for turning cells back into a pluripotent state. By partially reprogramming cells using a
Reversing Cellular Aging with Prof. Vittorio Sebastiano
April 4, 2019
We recently attended the Undoing Aging Conference in Berlin and had the opportunity to interview Professor Vittorio Sebastiano of Turn.Bio, a company developing partial cellular reprogramming techniques to reverse cellular aging. As we age, our cells experience changes to their epigenetic markers, and this, in turn,
An Interview with Dr. Judith Campisi
April 3, 2019
At Undoing Aging 2019, we interviewed some of the best researchers who are involved in discovering therapies for the root causes of aging. Their research aims to ameliorate the damages of aging and may one day lead to a future without age-related diseases. Dr. Judith Campisi,