Category: News
Undoing Aging in the Viewfinder
April 2, 2019
The day after I got back from the Undoing Aging 2019 scientific conference, which was jointly organized by the SENS Research Foundation and Forever Healthy Foundation, Moscow greeted me with
My Experiences At Undoing Aging 2019
April 1, 2019
Last Wednesday, I landed in Berlin, Germany at around 12:30. About an hour later, I was briefly in Cafè Alex, right next to the tapering TV Tower, where I met
The Life Extensionist’s Guide to Cognitive Biases
March 27, 2019
A cognitive bias is a systematic deviation from rational thought that can influence people’s reasoning without them even noticing. Several cognitive biases have been observed and studies over the past
Chronic Inflammation Leads to Toxic NET Buildup
March 26, 2019
A new review discusses how neutrophils release toxic substances into the body under inflammatory conditions, detailing one of the ways in which chronic inflammation causes long-term damage. Casting a deadly
Clearing Senescent Cells Prevents T1 Diabetes in Mice
March 7, 2019
Scientists have shown that the removal of non-dividing senescent cells, which are normally associated with aging, also appears to prevent Type 1 diabetes in diabetic mouse strains. Clearing senescent beta
Samsara Is Developing Autophagy Boosting Therapies
March 6, 2019
Samsara Therapeutics has completed a seed financing round in collaboration with Apollo Ventures, a venture capital company and biotech incubator that supports longevity research and treatments for age-related diseases. Samsara
Epigenetic Alterations and Reprogramming Potential in Aging
March 5, 2019
The role of epigenetics, which determine how your genes are expressed, is being increasingly implicated in aging, as is the potential of therapies that revert epigenetics back to those of
Rejuvenating Aged Brains by Waking Up Dormant Stem Cells
March 4, 2019
Researchers from the University of Luxembourg and the German Cancer Research Center have rejuvenated stem cells in the brains of old mice. The rejuvenated stem cells appear to improve regeneration
Boosting Cellular Housekeeping with Exercise and Fasting
February 28, 2019
In order to remain healthy and functional, cells have a number of maintenance systems that help them to dispose of metabolic waste and unwanted proteins. Autophagy is perhaps the best-known
Excessive Cell Size Contributes to Senescence
February 19, 2019
In a new study [1], researchers have identified the reason why cells become defective when they grow too large and why protein creation fails when cells grow larger than their
New Aging Clock Accurately Predicts Biological Age
February 15, 2019
Researchers at the Harvard T.H. Chan School of Public Health have discovered a new aging clock that can accurately determine both chronological and biological age in a wide variety of
Building a Company to End Age-Related Diseases
February 12, 2019
I recently visited the Longevity Leaders Conference in London and had the opportunity to speak with Kelsey Moody, the CEO of Ichor Therapeutics, a company focused on targeting age-related diseases
Removing Senescent Cells Improves Heart Health
February 11, 2019
Researchers at Newcastle University have shown that clearing out senescent cardiac muscle cells from the hearts of aged mice restores heart health. It seems that not a month goes by
Developing Better Senescent Cell Biomarkers
February 8, 2019
In aging research, there has long been a need for better biomarkers that can detect and confirm the presence of senescent cells. This has become particularly urgent in recent years
Longevity Leaders Conference Report
February 6, 2019
February 4th, 2019 saw the Longevity Leaders Conference hosted in Aldersgate, London. I was fortunate enough to have been invited to attend this interesting event, so I thought that today
Undoing Aging in the Viewfinder
April 2, 2019
The day after I got back from the Undoing Aging 2019 scientific conference, which was jointly organized by the SENS Research Foundation and Forever Healthy Foundation, Moscow greeted me with the first sunny days of the spring. Still tired and lacking sleep, but happy and inspired,
My Experiences At Undoing Aging 2019
April 1, 2019
Last Wednesday, I landed in Berlin, Germany at around 12:30. About an hour later, I was briefly in Cafè Alex, right next to the tapering TV Tower, where I met some of my colleagues from LEAF—some of whom I had never seen in person before—as well
The Life Extensionist’s Guide to Cognitive Biases
March 27, 2019
A cognitive bias is a systematic deviation from rational thought that can influence people’s reasoning without them even noticing. Several cognitive biases have been observed and studies over the past few decades, demonstrably influencing decision-making, self-perception, and preferences while affecting many human activities. Naturally, cognitive biases
Chronic Inflammation Leads to Toxic NET Buildup
March 26, 2019
A new review discusses how neutrophils release toxic substances into the body under inflammatory conditions, detailing one of the ways in which chronic inflammation causes long-term damage. Casting a deadly NET As we age, we suffer from the ever-increasing chronic inflammation known as inflammaging. This persistent,
Clearing Senescent Cells Prevents T1 Diabetes in Mice
March 7, 2019
Scientists have shown that the removal of non-dividing senescent cells, which are normally associated with aging, also appears to prevent Type 1 diabetes in diabetic mouse strains. Clearing senescent beta cells prevents T1 diabetes Type 1 diabetes (T1D) is a chronic condition in which the pancreas
Samsara Is Developing Autophagy Boosting Therapies
March 6, 2019
Samsara Therapeutics has completed a seed financing round in collaboration with Apollo Ventures, a venture capital company and biotech incubator that supports longevity research and treatments for age-related diseases. Samsara Therapeutics, Inc. (“Samsara,”) a platform biotechnology startup engaged in the discovery and development of compounds that
Epigenetic Alterations and Reprogramming Potential in Aging
March 5, 2019
The role of epigenetics, which determine how your genes are expressed, is being increasingly implicated in aging, as is the potential of therapies that revert epigenetics back to those of a younger person. What are epigenetic alterations? The DNA in each of our cells is identical,
Rejuvenating Aged Brains by Waking Up Dormant Stem Cells
March 4, 2019
Researchers from the University of Luxembourg and the German Cancer Research Center have rejuvenated stem cells in the brains of old mice. The rejuvenated stem cells appear to improve regeneration in areas of damaged or diseased brain tissue. A new way to model stem cells A
Boosting Cellular Housekeeping with Exercise and Fasting
February 28, 2019
In order to remain healthy and functional, cells have a number of maintenance systems that help them to dispose of metabolic waste and unwanted proteins. Autophagy is perhaps the best-known example of how cells purge their waste, and another is the ubiquitin-proteasome system (UPS). Researchers are
Excessive Cell Size Contributes to Senescence
February 19, 2019
In a new study [1], researchers have identified the reason why cells become defective when they grow too large and why protein creation fails when cells grow larger than their original healthy size, as is typically seen in aged and senescent cells. They demonstrate that in
New Aging Clock Accurately Predicts Biological Age
February 15, 2019
Researchers at the Harvard T.H. Chan School of Public Health have discovered a new aging clock that can accurately determine both chronological and biological age in a wide variety of species. Aging and the nucleolus There are two kinds of age: chronological age, which is strictly
Building a Company to End Age-Related Diseases
February 12, 2019
I recently visited the Longevity Leaders Conference in London and had the opportunity to speak with Kelsey Moody, the CEO of Ichor Therapeutics, a company focused on targeting age-related diseases by targeting the aging processes themselves. I previously interviewed him back in 2017, so it was
Removing Senescent Cells Improves Heart Health
February 11, 2019
Researchers at Newcastle University have shown that clearing out senescent cardiac muscle cells from the hearts of aged mice restores heart health. It seems that not a month goes by without a new study showing that senolytics, drugs that remove aged and damaged cells from the
Developing Better Senescent Cell Biomarkers
February 8, 2019
In aging research, there has long been a need for better biomarkers that can detect and confirm the presence of senescent cells. This has become particularly urgent in recent years due to the meteoric rise of the senescent cell-clearing therapies known as senolytics. Traditional ways of
Longevity Leaders Conference Report
February 6, 2019
February 4th, 2019 saw the Longevity Leaders Conference hosted in Aldersgate, London. I was fortunate enough to have been invited to attend this interesting event, so I thought that today was the ideal time to share some experiences of the conference with you. The conference was