Category: News
Removing Senescent Cells to Alleviate Muscular Dystrophy
September 14, 2022
A study published in Aging has shown that the removal of senescent cells through senolytics alleviates muscle degeneration in a mouse model of Duchenne muscular dystrophy. A genetic disease with
Neuromodulation Improves Memory in Older Adults
September 14, 2022
A new study published in Nature Neuroscience has shown that neuromodulation of low-frequency neuronal activity in the parietal cortex improved working memory, while high-frequency modulation in the prefrontal cortex improved
Injectable Cytokine Factories Eradicate Cancer in Mice
September 13, 2022
Researchers have succeeded in beating a type of cancer previously considered incurable by using microcapsules that contained live cytokine-producing cells [1]. IL-2 is potent but toxic Interleukin-2 (IL-2) therapy was
Ketogenic and Mediterranean Diets Effective Against Diabetes
September 12, 2022
Pitting a ketogenic diet against a Mediterranean diet in pre-diabetes and Type 2 diabetes patients, scientists have learned that both confer metabolic benefits, but “keto” also has a darker side
Lactate Inhibits Tumor Growth in Mice
September 9, 2022
Publishing in Nature, scientists have found that sodium lactate boosts the T cell-mediated anti-cancer immune response, leading to significant inhibition of tumor growth [1]. A double-edged sword As a means
Senescence-Associated Protein Promotes Skin Aging in Mice
September 8, 2022
Researchers publishing in Aging have identified an individual protein, secreted frizzled-related protein 4 (SFRP4), that is produced by senescent cells and contributes to skin aging in mice. The spread of
Brief Rapamycin Treatment in Early Adulthood Combats Aging
September 7, 2022
A study published in Nature Aging has shown that short-term rapamycin treatment in early adulthood extends lifespan in flies and improves gut health in both flies and mice [1]. A
Mitochondrial Division Promotes Muscle Regeneration
September 7, 2022
A paper published in Cell Stem Cell has detailed how mitochondrial division is critical to the ability of muscle stem cells to regenerate damaged tissue [1]. Waiting until needed This
Umbilical Plasma Injections Reduce Biological Age in Humans
September 6, 2022
Researchers have found that intramuscular injections of plasma concentrate made from human umbilical cord blood improve various health biomarkers and decrease biological age in elderly people [1]. Old blood, young
Canagliflozin Alleviates Several Aging Pathologies in Mice
September 5, 2022
Scientists have found that canagliflozin, an anti-diabetes drug that is known to extend lifespan in mice, alleviates an array of age-related pathologies, albeit in males only [1]. Anti-diabetes and anti-aging
Two Small Molecules May Provide Partial Reprogramming
September 5, 2022
A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. Beyond OSKM This
Zero-Calorie Sweeteners Alter the Human Microbiome
September 2, 2022
A new open-label, randomized, controlled study published in Cell showed that zero-calorie sweeteners are metabolically active and some might impair glycemic response in healthy adults [1]. What does “sugar-free” mean?
Rejuvenation Roundup August 2022
September 1, 2022
EARD2022 is over, but the research and events continue. Here’s a summary of everything that’s happened in August. LEAF News We are hiring! We are currently looking for a full-time
NAD+ Ameliorates Age-Related Hearing Loss in Mice
August 31, 2022
In a preprint published in bioRxiv, scientists have shown that long-term supplementation of nicotinamide riboside (NR), a NAD+ precursor, alleviates the progression of age-related hearing loss in a mouse model
Intravenous Stem Cells Alleviate Guinea Pig Osteoarthritis
August 30, 2022
Scientists have shown that intravenous delivery of mesenchymal stem cells, which has some advantages over the more conventional intra-articular injection, alleviates age-related osteoarthritis and decreases inflammation in guinea pigs [1].
Removing Senescent Cells to Alleviate Muscular Dystrophy
September 14, 2022
A study published in Aging has shown that the removal of senescent cells through senolytics alleviates muscle degeneration in a mouse model of Duchenne muscular dystrophy. A genetic disease with hallmarks of aging Duchenne muscular dystrophy is caused by a mutation that gradually destroys the muscles,
Neuromodulation Improves Memory in Older Adults
September 14, 2022
A new study published in Nature Neuroscience has shown that neuromodulation of low-frequency neuronal activity in the parietal cortex improved working memory, while high-frequency modulation in the prefrontal cortex improved long-term memory in older adults [1]. As people age, their cognitive abilities get worse. This includes
Injectable Cytokine Factories Eradicate Cancer in Mice
September 13, 2022
Researchers have succeeded in beating a type of cancer previously considered incurable by using microcapsules that contained live cytokine-producing cells [1]. IL-2 is potent but toxic Interleukin-2 (IL-2) therapy was the first anti-cancer immunotherapy approved decades ago. It is based on the ability of this inflammatory
Ketogenic and Mediterranean Diets Effective Against Diabetes
September 12, 2022
Pitting a ketogenic diet against a Mediterranean diet in pre-diabetes and Type 2 diabetes patients, scientists have learned that both confer metabolic benefits, but “keto” also has a darker side [1]. Diabetes is often reversible with diet While many anti-diabetes drugs have been developed in recent
Lactate Inhibits Tumor Growth in Mice
September 9, 2022
Publishing in Nature, scientists have found that sodium lactate boosts the T cell-mediated anti-cancer immune response, leading to significant inhibition of tumor growth [1]. A double-edged sword As a means of energy production, the Krebs cycle is preferred by most cells in most conditions. However, there
Senescence-Associated Protein Promotes Skin Aging in Mice
September 8, 2022
Researchers publishing in Aging have identified an individual protein, secreted frizzled-related protein 4 (SFRP4), that is produced by senescent cells and contributes to skin aging in mice. The spread of the SASP The authors of this paper introduce this topic with a familiar discussion of the
Brief Rapamycin Treatment in Early Adulthood Combats Aging
September 7, 2022
A study published in Nature Aging has shown that short-term rapamycin treatment in early adulthood extends lifespan in flies and improves gut health in both flies and mice [1]. A well-studied drug Rapamycin, an inhibitor of mTOR signaling, is capable of extending the lifespan of several
Mitochondrial Division Promotes Muscle Regeneration
September 7, 2022
A paper published in Cell Stem Cell has detailed how mitochondrial division is critical to the ability of muscle stem cells to regenerate damaged tissue [1]. Waiting until needed This paper begins with a discussion of quiescent muscle stem cells, which are held in reserve until
Umbilical Plasma Injections Reduce Biological Age in Humans
September 6, 2022
Researchers have found that intramuscular injections of plasma concentrate made from human umbilical cord blood improve various health biomarkers and decrease biological age in elderly people [1]. Old blood, young blood Circulating proteins have a significant impact on our health, and blood plasma transfusion is increasingly
Canagliflozin Alleviates Several Aging Pathologies in Mice
September 5, 2022
Scientists have found that canagliflozin, an anti-diabetes drug that is known to extend lifespan in mice, alleviates an array of age-related pathologies, albeit in males only [1]. Anti-diabetes and anti-aging Canagliflozin, a widely used anti-diabetes drug, belongs to the class of sodium glucose cotransporter 2 (SGLT2)
Two Small Molecules May Provide Partial Reprogramming
September 5, 2022
A preprint published in bioRxiv has detailed how partial reprogramming through two small molecules can rejuvenate human cells as well as C.elegans, a common model of aging. Beyond OSKM This paper begins with a discussion of the four well-known Yamanaka reprogramming factors (OSKM) that cause cells
Zero-Calorie Sweeteners Alter the Human Microbiome
September 2, 2022
A new open-label, randomized, controlled study published in Cell showed that zero-calorie sweeteners are metabolically active and some might impair glycemic response in healthy adults [1]. What does “sugar-free” mean? The human brain is the main consumer of glucose in the body, and glucose availability is
Rejuvenation Roundup August 2022
September 1, 2022
EARD2022 is over, but the research and events continue. Here’s a summary of everything that’s happened in August. LEAF News We are hiring! We are currently looking for a full-time chief of staff, a full-time data-driven Senior Marketing Manager, a part-time Youtube sponsorship/partnership acquisition lead, a
NAD+ Ameliorates Age-Related Hearing Loss in Mice
August 31, 2022
In a preprint published in bioRxiv, scientists have shown that long-term supplementation of nicotinamide riboside (NR), a NAD+ precursor, alleviates the progression of age-related hearing loss in a mouse model [1]. An overlooked hearing impairment Globally, age-related hearing loss (ARHL) is the most common sensory deficit
Intravenous Stem Cells Alleviate Guinea Pig Osteoarthritis
August 30, 2022
Scientists have shown that intravenous delivery of mesenchymal stem cells, which has some advantages over the more conventional intra-articular injection, alleviates age-related osteoarthritis and decreases inflammation in guinea pigs [1]. Systemic administration Osteoarthritis, a degenerative joint disease, is one of the most common causes of disability