Category: News
Different Tissues’ Proteins Age in Different Ways
July 14, 2022
An in-depth preprint published in bioRxiv has thoroughly described how separate tissues lose proteostasis in different ways. Segmental progeria As a model of accelerated aging, the researchers used an already
AI-Powered Novel Therapeutic Target Discovery
July 13, 2022
A new study conducted by Insilico Medicine in collaboration with leading aging research institutions has identified novel therapeutic targets for amyotrophic lateral sclerosis, a devastating age-associated neurodegenerative disease [1]. Disease
Short-Term Resveratrol Reverses Ovarian Aging in Mice
July 12, 2022
Researchers have shown that resveratrol reverses several features of ovarian aging in mice while activating most sirtuins and boosting mitochondrial health [1]. Ovaries age first In many mammals, including humans,
Fruits and Vegetables Linked to Fewer Cognitive Disorders
July 11, 2022
A meta-analysis published in Frontiers in Nutrition has found that intake of fruits and vegetables is negatively correlated with cognitive decline in older adults. A study of studies Sixteen different
Vadim Gladyshev on the Fundamentals of Aging
July 8, 2022
Vadim Gladyshev is a Professor of Medicine at Brigham and Women’s Hospital and Harvard Medical School, and he is one of the most prominent figures in geroscience today. We discussed
Metformin, Rapamycin, NMN, and Vascular Cognitive Impairment
July 7, 2022
A study published in Frontiers in Neurology has detailed how three well-known longevity-associated compounds affect vascular cognitive impairment (VCI) in a rat model. A rat model of a common human
Rejuvenating the Brain with Transplanted Astrocytes
July 6, 2022
A new study published in Stem Cell Research and Therapy has shown that rejuvenating the astrocyte niche in the aged brains of mice leads to improved nervous system function at
Politicians Live Longer Than Most People
July 5, 2022
By analyzing historical data, scientists have shown that politicians, an example of an elite group, have enjoyed longer than average life expectancy since about 1950 [1]. The elite lives longer
Extracellular Matrix in Aging with Professor Collin Ewald
July 4, 2022
Dr. Collin Ewald is a molecular biologist and a professor at the Swiss Federal Institute of Technology in Zürich (ETH). At ETH, Collin leads the Laboratory of Extracellular Matrix (ECM)
Old Human Skin Rejuvenated When Implanted in Young Mice
July 1, 2022
Publishing in Science, researchers have transplanted old human skin to young mice and witnessed a robust rejuvenation cascade that is probably triggered by vascular growth [1]. New life for old
Rejuvenation Roundup June 2022
July 1, 2022
As rejuvenation biotechnology begins to take root, more and more biotech companies are joining the fight against aging. Here’s what’s happened in research, development, investment, and advocacy last month. LEAF
Metformin Is Linked to Weaker Exercise Improvements
June 30, 2022
A study published in Obesity suggests that metformin may decrease the gains in cardiorespiratory performance brought on by exercise. The world’s most common diabetes drug Metabolic syndrome, which is represented
H+ DAO and Transhumanism with Dr. Natasha Vita-More
June 30, 2022
“Transhumanism is a philosophy, worldview, and a movement,” Dr. Natasha Vita-More states in the book “Transhumanism: What is it?” Essentially, it’s the idea of being able to move beyond being
Longevity Through Altering Essential Gene Expression
June 29, 2022
In a new study published in GeroScience, researchers have shown that it is possible to significantly increase yeast lifespan by overexpressing genes highly conserved across various species [1]. Survival and
Cocoa Extract Reduces Cardiovascular Mortality
June 28, 2022
A large-scale, randomized, controlled trial has found that in aging adults, cocoa extract does not affect the prevalence of adverse cardiovascular events but decreases their lethality [1]. Rich in flavanols
Different Tissues’ Proteins Age in Different Ways
July 14, 2022
An in-depth preprint published in bioRxiv has thoroughly described how separate tissues lose proteostasis in different ways. Segmental progeria As a model of accelerated aging, the researchers used an already short-lived vertebrate, the killifish, with a mutation that impairs its ability to create telomerase. This results
AI-Powered Novel Therapeutic Target Discovery
July 13, 2022
A new study conducted by Insilico Medicine in collaboration with leading aging research institutions has identified novel therapeutic targets for amyotrophic lateral sclerosis, a devastating age-associated neurodegenerative disease [1]. Disease and aging: not that different Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease. It is
Short-Term Resveratrol Reverses Ovarian Aging in Mice
July 12, 2022
Researchers have shown that resveratrol reverses several features of ovarian aging in mice while activating most sirtuins and boosting mitochondrial health [1]. Ovaries age first In many mammals, including humans, ovarian aging is premature compared to other systems. The reasons for this accelerated loss of function
Fruits and Vegetables Linked to Fewer Cognitive Disorders
July 11, 2022
A meta-analysis published in Frontiers in Nutrition has found that intake of fruits and vegetables is negatively correlated with cognitive decline in older adults. A study of studies Sixteen different studies were used for this meta-analysis, and not all of them measured fruit and vegetable comsuption
Vadim Gladyshev on the Fundamentals of Aging
July 8, 2022
Vadim Gladyshev is a Professor of Medicine at Brigham and Women’s Hospital and Harvard Medical School, and he is one of the most prominent figures in geroscience today. We discussed various competing hypotheses on the nature of aging, the lack of the unified theory of aging
Metformin, Rapamycin, NMN, and Vascular Cognitive Impairment
July 7, 2022
A study published in Frontiers in Neurology has detailed how three well-known longevity-associated compounds affect vascular cognitive impairment (VCI) in a rat model. A rat model of a common human disease In bilateral common carotid artery occlusion (BCCAO), the arteries of rats are sutured to reduce
Rejuvenating the Brain with Transplanted Astrocytes
July 6, 2022
A new study published in Stem Cell Research and Therapy has shown that rejuvenating the astrocyte niche in the aged brains of mice leads to improved nervous system function at both the cellular and organismal levels [1]. A glia-centric approach In brain aging, neurons are quite
Politicians Live Longer Than Most People
July 5, 2022
By analyzing historical data, scientists have shown that politicians, an example of an elite group, have enjoyed longer than average life expectancy since about 1950 [1]. The elite lives longer Historical trends in health and mortality can teach us a lot about the present. It is
Extracellular Matrix in Aging with Professor Collin Ewald
July 4, 2022
Dr. Collin Ewald is a molecular biologist and a professor at the Swiss Federal Institute of Technology in Zürich (ETH). At ETH, Collin leads the Laboratory of Extracellular Matrix (ECM) Regeneration. Here, his research focuses on age-related ECM remodeling and related longevity interventions. We caught up
Old Human Skin Rejuvenated When Implanted in Young Mice
July 1, 2022
Publishing in Science, researchers have transplanted old human skin to young mice and witnessed a robust rejuvenation cascade that is probably triggered by vascular growth [1]. New life for old skin Our skin begins to age relatively early, and this conspicuous process gave rise to a
Rejuvenation Roundup June 2022
July 1, 2022
As rejuvenation biotechnology begins to take root, more and more biotech companies are joining the fight against aging. Here’s what’s happened in research, development, investment, and advocacy last month. LEAF News Our fifth annual conference, Ending Age-Related Diseases 2022, will be coming up next month. Our
Metformin Is Linked to Weaker Exercise Improvements
June 30, 2022
A study published in Obesity suggests that metformin may decrease the gains in cardiorespiratory performance brought on by exercise. The world’s most common diabetes drug Metabolic syndrome, which is represented by the four connected symptoms of obesity, excessive fats in the bloodstream (dyslipidemia), high blood pressure
H+ DAO and Transhumanism with Dr. Natasha Vita-More
June 30, 2022
“Transhumanism is a philosophy, worldview, and a movement,” Dr. Natasha Vita-More states in the book “Transhumanism: What is it?” Essentially, it’s the idea of being able to move beyond being human, and finding solutions to living longer, healthier lives. Natasha is an Executive Director of Humanity+,
Longevity Through Altering Essential Gene Expression
June 29, 2022
In a new study published in GeroScience, researchers have shown that it is possible to significantly increase yeast lifespan by overexpressing genes highly conserved across various species [1]. Survival and aging The question of the effects of nature versus nurture, or programmed versus stochastic, sparks hot
Cocoa Extract Reduces Cardiovascular Mortality
June 28, 2022
A large-scale, randomized, controlled trial has found that in aging adults, cocoa extract does not affect the prevalence of adverse cardiovascular events but decreases their lethality [1]. Rich in flavanols The nutrients that we consume obviously impact our healthspan and lifespan, but studying their effects in