Category: News
Using Gene Expression to Target Senescent Cells
March 14, 2022
An open access study published in iScience has discussed the development of senolytics to target particular genes that are upregulated in cellular senescence. Understanding senescence, cell by cell In our
Tuberculosis Is Associated with Epigenetic Aging
March 11, 2022
Publishing in Aging, a team of researchers has explained the relationship between tuberculosis (TB) and multiple aspects of aging, including epigenetic alterations and the senescence-associated secretory phenotype (SASP). A disease
Long-Term Cellular Reprogramming Causes Rejuvenation in Mice
March 11, 2022
Scientists have shown that in vivo partial cellular reprogramming can be safe and effective in an animal model, although the rejuvenation was mostly limited to long-term treatments and two tissue
Meat Consumption Increases Risk of Some Types of Cancer
March 10, 2022
In a new population study, scientists have found more evidence that consuming a lot of meat might not be a good idea, though the association between meat and cancer depends
Vitamin D Dosing Safety in a Randomized, Controlled Trial
March 9, 2022
New data has been released from the Vitamin D Type 2 Diabetes (D2d) study [1]. This study is a randomized, controlled trial that includes overweight and obese people studied at
Dr. Simon Melov on Single Cell Genomics
March 8, 2022
Dr. Simon Melov is a professor at the Buck Institute for Research on Aging. His lab is working on identifying the molecular hallmarks of aging, specifically in the context of
SENS Researchers Culture Immune Cells to Fight Senescence
March 7, 2022
Publishing in Aging, a team of researchers from SENS Research Foundation has described a new method of enriching natural killer (NK) cells to fight senescent cells. Culturing NK cells to
Exercise Improves Cognition Depending on Type and Amount
March 4, 2022
In a new review paper, scientists show that exercise can alleviate age-related cognitive decline, but not all types of exercise are created equal [1]. Watch your head Lifestyle choices, such
Gut Viruses Found to Improve Cognition in Humans
March 3, 2022
A study published in Cell Host & Microbe has found that members of the Cuadovirales viral order positively affect cognition in multiple species, including humans. Viruses in the human body,
Carotid Bodies Play a Role in Glucose Regulation
March 2, 2022
An advance online preprint was recently released in Circulation Research examining carotid bodies’ role in hypertension and diabetes [1]. It will be published in the journal later this week. Drugs
Chloroquine Increases Maximum Lifespan in Rats by 13%
March 1, 2022
Scientists have shown that chloroquine, a well-known anti-malarial drug and the cousin of hydroxychloroquine, attenuates inflammation and fibrosis while significantly extending median and maximum lifespan in naturally aged rats [1].
Rejuvenation Roundup February 2022
March 1, 2022
February might be the shortest month, but it’s still full of exciting research on the path towards ending age-related diseases, including senolytics and new ways of looking at epigenetics. Let’s
Combining Epigenetic and Imaging Biomarkers
February 28, 2022
Cardiologists, epidemiologists, and other researchers publishing in Aging have discovered that epigenetic aging and brain scans can be combined to accurately predict cognitive decline. Two entirely different measurements The ongoing
Resveratrol Ameliorates Erectile Dysfunction in Old Rats
February 25, 2022
Scientists have shown that resveratrol rescues erectile function in aged rats, most probably by activating SIRT1, and that it can work in synergy with the existing erectile dysfunction treatment tadalafil
The Effects of Early Life Rapamycin Administration on Mice
February 24, 2022
A team of researchers, including Steve Horvath, Leonid Peshkin, and Vadim Gladyshev, has published a preprint on bioRxiv showing the effects of early administration of rapamycin over the lifespans of
Using Gene Expression to Target Senescent Cells
March 14, 2022
An open access study published in iScience has discussed the development of senolytics to target particular genes that are upregulated in cellular senescence. Understanding senescence, cell by cell In our earlier interview with Simon Melov of the Buck Institute, the lead researcher of this paper, Dr.
Tuberculosis Is Associated with Epigenetic Aging
March 11, 2022
Publishing in Aging, a team of researchers has explained the relationship between tuberculosis (TB) and multiple aspects of aging, including epigenetic alterations and the senescence-associated secretory phenotype (SASP). A disease known to cause long-term harm Tuberculosis, a disease that has proliferated around the world, kills 1.4
Long-Term Cellular Reprogramming Causes Rejuvenation in Mice
March 11, 2022
Scientists have shown that in vivo partial cellular reprogramming can be safe and effective in an animal model, although the rejuvenation was mostly limited to long-term treatments and two tissue types [1]. There and back again Cellular reprogramming sounds like a technology from Star Trek, and
Meat Consumption Increases Risk of Some Types of Cancer
March 10, 2022
In a new population study, scientists have found more evidence that consuming a lot of meat might not be a good idea, though the association between meat and cancer depends on multiple factors [1]. Diet and health Given that lifestyle changes may be the only anti-aging
Vitamin D Dosing Safety in a Randomized, Controlled Trial
March 9, 2022
New data has been released from the Vitamin D Type 2 Diabetes (D2d) study [1]. This study is a randomized, controlled trial that includes overweight and obese people studied at 22 academic medical centers in the United States. This data was collected between October 2013 and
Dr. Simon Melov on Single Cell Genomics
March 8, 2022
Dr. Simon Melov is a professor at the Buck Institute for Research on Aging. His lab is working on identifying the molecular hallmarks of aging, specifically in the context of cellular senescence. Recently, the lab published a paper in which it announced a discovery of a
SENS Researchers Culture Immune Cells to Fight Senescence
March 7, 2022
Publishing in Aging, a team of researchers from SENS Research Foundation has described a new method of enriching natural killer (NK) cells to fight senescent cells. Culturing NK cells to fight senescence Previous experiments have shown that natural killer (NK) cells are partially responsible for the
Exercise Improves Cognition Depending on Type and Amount
March 4, 2022
In a new review paper, scientists show that exercise can alleviate age-related cognitive decline, but not all types of exercise are created equal [1]. Watch your head Lifestyle choices, such as exercise and diet, are the most powerful anti-aging interventions currently available to us, and they
Gut Viruses Found to Improve Cognition in Humans
March 3, 2022
A study published in Cell Host & Microbe has found that members of the Cuadovirales viral order positively affect cognition in multiple species, including humans. Viruses in the human body, but not human viruses Cuadovirales is an order of bacteriophages, which infect bacteria rather than animal
Carotid Bodies Play a Role in Glucose Regulation
March 2, 2022
An advance online preprint was recently released in Circulation Research examining carotid bodies’ role in hypertension and diabetes [1]. It will be published in the journal later this week. Drugs that target the glucagon-like peptide 1 (GLP1) receptor are widely used to treat type 2 diabetes
Chloroquine Increases Maximum Lifespan in Rats by 13%
March 1, 2022
Scientists have shown that chloroquine, a well-known anti-malarial drug and the cousin of hydroxychloroquine, attenuates inflammation and fibrosis while significantly extending median and maximum lifespan in naturally aged rats [1]. Fighting malaria since 1934 Chloroquine (CQ) was developed back in 1934 as an anti-malarial treatment and as
Rejuvenation Roundup February 2022
March 1, 2022
February might be the shortest month, but it’s still full of exciting research on the path towards ending age-related diseases, including senolytics and new ways of looking at epigenetics. Let’s see what’s happened in these four weeks. LEAF News Life Noggin Joins the Lifespan.io Family: Today,
Combining Epigenetic and Imaging Biomarkers
February 28, 2022
Cardiologists, epidemiologists, and other researchers publishing in Aging have discovered that epigenetic aging and brain scans can be combined to accurately predict cognitive decline. Two entirely different measurements The ongoing CARDIA study was started in 1985 to monitor coronary artery risk development in young adults (who
Resveratrol Ameliorates Erectile Dysfunction in Old Rats
February 25, 2022
Scientists have shown that resveratrol rescues erectile function in aged rats, most probably by activating SIRT1, and that it can work in synergy with the existing erectile dysfunction treatment tadalafil [1]. A molecule of discord Resveratrol, a plant-derived chemical of the polyphenol family, was once considered
The Effects of Early Life Rapamycin Administration on Mice
February 24, 2022
A team of researchers, including Steve Horvath, Leonid Peshkin, and Vadim Gladyshev, has published a preprint on bioRxiv showing the effects of early administration of rapamycin over the lifespans of mice. Rapamycin before and after weaning In this placebo-controlled experiment, the researchers selected the UMHET3 strain