Category: News
Telomerase Alleviates Alzheimer’s Symptoms not via Telomeres
January 21, 2022
Scientists publishing in Nature Aging have shown that telomerase reverse transcriptase slows neurodegeneration but not due to its telomere-building activity [1]. Chromosomes’ bodyguards The word “telomerase” rings a huge bell
Journal Club January 2022 – CAR T cells produced in vivo to treat cardiac injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month
CAR T Cells Produced in Vivo to Treat Cardiac Injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month
An Open Access Research Tool for Lifespan Comparisons
January 21, 2022
Dr. Leon Peshkin talks us through a new open access research tool he has helped to develop. The Animal Life Expectancy Comparisons Research Tool (ALEC)Â is free for researchers to use
Heat Shock Protein Fights Senescence in Macular Degeneration
January 20, 2022
Researchers publishing in Experimental Eye Research have discovered that the peptide aB-crystallin can reduce the cellular senescence that affects the progression of age-related macular degeneration (AMD). What is αB-crystallin? αB-crystallin
Altos Labs’ $3 Billion Launch to Reverse Cellular Aging
January 20, 2022
In September 2021, we reported that Altos Labs was about to launch an ambitious project to develop partial cellular reprogramming to the point where it could be safely used in
Epigenetic Age Acceleration Is Linked to Hearing Loss
January 19, 2022
A study published in Frontiers in Aging Neuroscience examined the relationship between epigenetic age acceleration and hearing [1]. Since 1958, a team of researchers from the National Institute on Aging
Quercetin Improves Bone Regeneration in Older Rats
January 19, 2022
A new study in ACS Applied Materials and Interfaces used a combined geroscience and tissue engineering approach to regenerate bone in aged rats [1]. Replacement or rejuvenation? Too often, tissue
Fasting-Mimicking Diet Helps Fight Cancer
January 18, 2022
In the first human trial of its kind, scientists showed that a fasting-mimicking diet can work synergistically with conventional therapies in cancer patients, altering their metabolisms and reshaping their immune
OKN-007 Protects Mouse Spinal Cords
January 17, 2022
Publishing in GeroScience, a team of Oklahoma City researchers has found that a nitrone compound with a low molecular weight, OKN-007, maintains motor neuron functionality in the spinal cords of
Dr. Brian Kennedy: From Sickcare to Healthcare
January 14, 2022
Dr. Brian Kennedy is a longevity heavyweight: a former President of the Buck Institute, currently a Distinguished Professor in the Department of Biochemistry and Physiology at the National University of
Key Parkinson’s Protein Required for Immune Function
January 13, 2022
A study published in Cell Reports has found α-synuclein, the fundamental protein of Parkinson’s disease, to be critical in immune function. The gut-brain axis as a channel for disease Parkinson’s
The Effects of Metformin and Lifestyle on Mortality
January 12, 2022
An outcomes study conducted by the Diabetes Prevention Program (DPP) has examined the effects of lifestyle interventions and the popular diabetes drug metformin on all-cause mortality. Background The original DPP
Isthmin 1 as a Biomarker and Therapeutic Target for Aging
January 12, 2022
A recent study published in Biogerontology has discovered a potential new aging biomarker and longevity therapeutic target [1]. Isthmin 1 (Ism1) in aging fish Ism1 is not a well-known protein,
Genetically Engineered T Cells Reduce Cardiac Fibrosis
January 11, 2022
Scientists have created genetically engineered T cells that target activated cardiac fibroblasts in a transient manner, alleviating symptoms of cardiac injury [1]. Engineered immune cells CAR T cell therapy is
Telomerase Alleviates Alzheimer’s Symptoms not via Telomeres
January 21, 2022
Scientists publishing in Nature Aging have shown that telomerase reverse transcriptase slows neurodegeneration but not due to its telomere-building activity [1]. Chromosomes’ bodyguards The word “telomerase” rings a huge bell for people who are familiar with geroscience. The primary function of this ribonucleoprotein complex (it consists
Journal Club January 2022 – CAR T cells produced in vivo to treat cardiac injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month is the paper ‘CAR T cells produced in vivo to treat cardiac injury‘ which looks at
CAR T Cells Produced in Vivo to Treat Cardiac Injury
January 21, 2022
Hosted by Dr. Oliver Medvedik, Journal Club returns on Tuesday 25th January at 12:00 Eastern and will be broadcast live on the Lifespan.io Facebook page. The topic for this month is the paper ‘CAR T cells produced in vivo to treat cardiac injury‘, which looks at
An Open Access Research Tool for Lifespan Comparisons
January 21, 2022
Dr. Leon Peshkin talks us through a new open access research tool he has helped to develop. The Animal Life Expectancy Comparisons Research Tool (ALEC)Â is free for researchers to use now. If a drug increases lifespan in mice by 15%, should I take it? The idea
Heat Shock Protein Fights Senescence in Macular Degeneration
January 20, 2022
Researchers publishing in Experimental Eye Research have discovered that the peptide aB-crystallin can reduce the cellular senescence that affects the progression of age-related macular degeneration (AMD). What is αB-crystallin? αB-crystallin is a well-known heat shock protein, a family of proteins that is used in temperature regulation.
Altos Labs’ $3 Billion Launch to Reverse Cellular Aging
January 20, 2022
In September 2021, we reported that Altos Labs was about to launch an ambitious project to develop partial cellular reprogramming to the point where it could be safely used in humans to reverse cellular aging. That launch has now officially started, and Altos Labs is shaping
Epigenetic Age Acceleration Is Linked to Hearing Loss
January 19, 2022
A study published in Frontiers in Aging Neuroscience examined the relationship between epigenetic age acceleration and hearing [1]. Since 1958, a team of researchers from the National Institute on Aging Intramural Research program has been conducting the Baltimore Longitudinal Study of Aging (BLSA). The BLSA study
Quercetin Improves Bone Regeneration in Older Rats
January 19, 2022
A new study in ACS Applied Materials and Interfaces used a combined geroscience and tissue engineering approach to regenerate bone in aged rats [1]. Replacement or rejuvenation? Too often, tissue engineering and longevity therapeutics are viewed as competing strategies – two different paths to potentially combat
Fasting-Mimicking Diet Helps Fight Cancer
January 18, 2022
In the first human trial of its kind, scientists showed that a fasting-mimicking diet can work synergistically with conventional therapies in cancer patients, altering their metabolisms and reshaping their immune systems [1]. What happens when you fast? Fasting is shaping up to be a powerful addition
OKN-007 Protects Mouse Spinal Cords
January 17, 2022
Publishing in GeroScience, a team of Oklahoma City researchers has found that a nitrone compound with a low molecular weight, OKN-007, maintains motor neuron functionality in the spinal cords of aging mice. Prior research OKN-007 is not new in the literature. This is a nitrone compound,
Dr. Brian Kennedy: From Sickcare to Healthcare
January 14, 2022
Dr. Brian Kennedy is a longevity heavyweight: a former President of the Buck Institute, currently a Distinguished Professor in the Department of Biochemistry and Physiology at the National University of Singapore, a co-editor of Aging Cell, and one of the researchers behind a recent study of
Key Parkinson’s Protein Required for Immune Function
January 13, 2022
A study published in Cell Reports has found α-synuclein, the fundamental protein of Parkinson’s disease, to be critical in immune function. The gut-brain axis as a channel for disease Parkinson’s disease, which causes damage to the portion of the brain responsible for movement, is widely known
The Effects of Metformin and Lifestyle on Mortality
January 12, 2022
An outcomes study conducted by the Diabetes Prevention Program (DPP) has examined the effects of lifestyle interventions and the popular diabetes drug metformin on all-cause mortality. Background The original DPP was conducted at 27 centers in the United States from 1996 to 2001. Building upon this
Isthmin 1 as a Biomarker and Therapeutic Target for Aging
January 12, 2022
A recent study published in Biogerontology has discovered a potential new aging biomarker and longevity therapeutic target [1]. Isthmin 1 (Ism1) in aging fish Ism1 is not a well-known protein, but it has been shown to play a role in multiple aspects of biology. It contributes
Genetically Engineered T Cells Reduce Cardiac Fibrosis
January 11, 2022
Scientists have created genetically engineered T cells that target activated cardiac fibroblasts in a transient manner, alleviating symptoms of cardiac injury [1]. Engineered immune cells CAR T cell therapy is a much-touted novel technique that makes use of an organism’s own immune system. CAR stands for