Category: News
Senolytics for Cardiac Regeneration in Diabetics
February 9, 2022
The latest research published in Diabetes has implicated senescent cardiac stem cells as the link between diabetes and cardiovascular disease [1]. Why does diabetes increase the risk of cardiovascular disease?
Longevity Allele Slows Immune and Cardiovascular Aging
February 8, 2022
In a new study, mice transduced with a longevity-associated variant (LAV) of the BPIFB4 gene showed less immunosenescence and healthier vasculature [1]. The importance of having good genes Longevity-associated alleles
Mapping the Gene Expression of Senescent Brain Cells
February 7, 2022
As explained in a paper published in GeroScience, researchers have used spatial transcriptomic analysis to show the inflammatory nodes that are caused by brain cells undergoing senescence. What is spatial
Effective New Method of Cellular Reprogramming Proposed
February 4, 2022
Scientists have proposed a novel method of cellular reprogramming that is more predictable and effective than traditional methods [1]. Geroscience’s Holy Grail Cellular reprogramming is a hot topic in geroscience
Naked Mole Rats Age, but Not Like Other Mammals
February 3, 2022
A research paper published in Nature by Dr. Vadim Gladyshev and his team has investigated the epigenetic aging of the naked mole rat, an animal whose mortality rate does not
Higher Diet Quality Is Linked to Reduced Epigenetic Aging
February 2, 2022
A study published in the American Journal of Clinical Nutrition examined the relationship between diet quality and epigenetic aging clocks [1]. This study used data from the Framingham Heart Study
Brain Cell Types Respond Differently to Aging Interventions
February 2, 2022
A new preprint on bioRxiv shows how researchers have developed transcriptomic, cell type specific aging clocks from the regenerative zones of mouse brains [1]. Measuring age at the level of
Senolytic Navitoclax Rescues Neurogenesis and Memory in Mice
February 1, 2022
Scientists have shown that clearing senescent neural precursor cells with the senolytic drug navitoclax reverses the age-related decline in neurogenesis and improves spatial memory in mice [1]. Not to be
Rejuvenation Roundup January 2022
February 1, 2022
Rejuvenation biotechnology is beginning to pick up steam, with major companies, political activism, and new approaches on the horizon. Let’s see what’s been done in January. LEAF News Creating Political
Targeting Metabolism To Slow Down Aging
January 31, 2022
Publishing in Aging, a group of Korean researchers has discovered a compound that affects the way our mitochondria process energy, ameliorating cellular senescence. A deep dive into biochemistry To begin
Sonia Arrison: “Aging Is One of the Last Unifying Issues”
January 31, 2022
Sonia Arrison is an entrepreneur, investor, and best-selling author. Her book “100 Plus: How the Coming Age of Longevity Will Change Everything”, published in 2011, was one of the first
A New Startup Is Going After Rogue Cells
January 28, 2022
In a blog post, the founder and CEO of Arda Therapeutics, Adam Freund, explained his company’s intriguing strategy along with why it is imperative to counter aging. From Calico to
Senolytics Restore Cognitive Ability in Aged Rats
January 27, 2022
Polish researchers publishing in Aging have discovered that the well-known senolytic combination of dasatinib and quercetin improves the cognitive capabilities of older rats. Understanding neuroplasticity While new neurons can be
Dietary Fiber and Probiotics Affect Melanoma Immunotherapy
January 26, 2022
A study published in Science by Dr. Jennifer A. Wargo and her colleagues spanning multiple centers recently examined if dietary fiber and commercially available probiotics affect immunotherapy response in cancer
Meta-Analysis Discovers Goldilocks Zone for IGF-1
January 26, 2022
A new meta-analysis from Aging Cell has shown that both high and low levels of IGF-1 are related to mortality risk [1]. Insulin-like growth factor 1 (IGF-1) IGF-1 is one
Senolytics for Cardiac Regeneration in Diabetics
February 9, 2022
The latest research published in Diabetes has implicated senescent cardiac stem cells as the link between diabetes and cardiovascular disease [1]. Why does diabetes increase the risk of cardiovascular disease? Type 2 diabetes mellitus is closely related to aging. Aging is a major risk factor for
Longevity Allele Slows Immune and Cardiovascular Aging
February 8, 2022
In a new study, mice transduced with a longevity-associated variant (LAV) of the BPIFB4 gene showed less immunosenescence and healthier vasculature [1]. The importance of having good genes Longevity-associated alleles prove that aging does not affect everyone equally. On average, centenarians and supercentenarians are more protected
Mapping the Gene Expression of Senescent Brain Cells
February 7, 2022
As explained in a paper published in GeroScience, researchers have used spatial transcriptomic analysis to show the inflammatory nodes that are caused by brain cells undergoing senescence. What is spatial transcriptomic analysis? Spatial transcription analysis isn’t a full 3D view of an entire brain. Rather, it
Effective New Method of Cellular Reprogramming Proposed
February 4, 2022
Scientists have proposed a novel method of cellular reprogramming that is more predictable and effective than traditional methods [1]. Geroscience’s Holy Grail Cellular reprogramming is a hot topic in geroscience that is being pursued by many academics and companies, including major players such as Google’s Calico
Naked Mole Rats Age, but Not Like Other Mammals
February 3, 2022
A research paper published in Nature by Dr. Vadim Gladyshev and his team has investigated the epigenetic aging of the naked mole rat, an animal whose mortality rate does not appear to increase with age. Do naked mole rats actually age? In this paper, the researchers
Higher Diet Quality Is Linked to Reduced Epigenetic Aging
February 2, 2022
A study published in the American Journal of Clinical Nutrition examined the relationship between diet quality and epigenetic aging clocks [1]. This study used data from the Framingham Heart Study Offspring Cohort. This specific study noted the Dietary Approaches to Stop Hypertension (DASH) scores, which are
Brain Cell Types Respond Differently to Aging Interventions
February 2, 2022
A new preprint on bioRxiv shows how researchers have developed transcriptomic, cell type specific aging clocks from the regenerative zones of mouse brains [1]. Measuring age at the level of a single cell Aging is multi-faceted and difficult to quantify. While chronological age is straightforward, it
Senolytic Navitoclax Rescues Neurogenesis and Memory in Mice
February 1, 2022
Scientists have shown that clearing senescent neural precursor cells with the senolytic drug navitoclax reverses the age-related decline in neurogenesis and improves spatial memory in mice [1]. Not to be replaced The brain is an organ of special concern for geroscientists. It is theorized that we
Rejuvenation Roundup January 2022
February 1, 2022
Rejuvenation biotechnology is beginning to pick up steam, with major companies, political activism, and new approaches on the horizon. Let’s see what’s been done in January. LEAF News Creating Political Action to Increase Healthy Human Lifespan: A recent online discussion panel revealed some valuable insights into
Targeting Metabolism To Slow Down Aging
January 31, 2022
Publishing in Aging, a group of Korean researchers has discovered a compound that affects the way our mitochondria process energy, ameliorating cellular senescence. A deep dive into biochemistry To begin their paper, the researchers discuss the role of the SASP, the inflammatory cytokine IL-33, and the
Sonia Arrison: “Aging Is One of the Last Unifying Issues”
January 31, 2022
Sonia Arrison is an entrepreneur, investor, and best-selling author. Her book “100 Plus: How the Coming Age of Longevity Will Change Everything”, published in 2011, was one of the first to bring the topic of longevity to the general public’s attention. Sonia is also founder of
A New Startup Is Going After Rogue Cells
January 28, 2022
In a blog post, the founder and CEO of Arda Therapeutics, Adam Freund, explained his company’s intriguing strategy along with why it is imperative to counter aging. From Calico to Arda It’s not every day that the longevity field sees a new player with a fresh
Senolytics Restore Cognitive Ability in Aged Rats
January 27, 2022
Polish researchers publishing in Aging have discovered that the well-known senolytic combination of dasatinib and quercetin improves the cognitive capabilities of older rats. Understanding neuroplasticity While new neurons can be formed in the adult hippocampus through neurogenesis [1], learning and behavioral changes caused by changes in
Dietary Fiber and Probiotics Affect Melanoma Immunotherapy
January 26, 2022
A study published in Science by Dr. Jennifer A. Wargo and her colleagues spanning multiple centers recently examined if dietary fiber and commercially available probiotics affect immunotherapy response in cancer patients [1]. They hypothesized that bacteria from two probiotic species would be associated with a response
Meta-Analysis Discovers Goldilocks Zone for IGF-1
January 26, 2022
A new meta-analysis from Aging Cell has shown that both high and low levels of IGF-1 are related to mortality risk [1]. Insulin-like growth factor 1 (IGF-1) IGF-1 is one of the body’s major metabolic hormones. It can have effects similar to insulin, and it mediates