Category: News
Rejuvenation Roundup August 2021
September 1, 2021
August is over, and with it, our annual Ending Age-Related Diseases conference! EARD2021 was a great success, and we would like to thank our attendees and sponsors for their support.
What are Senolytics? A Summary of Senotherapeutics
September 1, 2021
In this article we will take a look at senolytics and how they have the potential to reverse some aspects of the aging process. Senescent cells and aging As your
The Road Between Inflammation and Heart Aging
August 31, 2021
A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have
Early Antibiotic Exposure Can Decrease Lifespan in Mice
August 30, 2021
A study published in Cell Reports has shown that early-life exposure to antibiotics that destroy the gut flora can harm the lifelong development of mice, including lifespan. Three groups with
DunedinPACE – A Next Generation Epigenetic Aging Clock
August 27, 2021
With so many health and disease outcomes connected to the biological aging processes, research into quantifying and tracking aging has surged in recent years due to the work of Steve
What is Resveratrol? A Summary of Resveratrol
August 26, 2021
Probably best known for its presence in grapes and wine, this popular dietary supplement may have a few tricks up its sleeve. What is resveratrol? Resveratrol is a stilbenoid, a
Collagen, Senescence, and Age-Related Hair Loss
August 25, 2021
Last week, a new study published in Aging reported similar mechanisms of TGF-ß2 and collagen on hair follicle aging, dermal papilla cell senescence, and in vitro spheroid formation. Aging hair
Working the Deletion Problem out of CRISPR
August 24, 2021
In a study published in Genome Biology, researchers explain how they are working to make CRISPR less prone to large, accidental deletions of genetic material [1]. A previously unknown large
Stress, Sensory Gating, and Cognitive Decline With Age
August 23, 2021
Researchers publishing in Aging have found that stresses, both biological and in daily life, harm one of our fundamental abilities to correctly process what’s going on around us. What is
Longeveron Takes Aim at Aging with Cell Therapy
August 18, 2021
Longeveron has just announced the first data from its Phase 2b clinical trial that targets frailty with Lomecel-B, an MSC-based cell therapy. A longevity strategy built in More and more,
The Hedgehog Protein Reduces Microglial Inflammation in Mice
August 17, 2021
Researchers, publishing in the journal Aging, have discovered that a protein called hedgehog alleviates the tissue-specific, age-related inflammation of the microglia, the maintenance cells of the brain. The aging differences
Stem Cell Helper Heat Shock Protein Identified
August 16, 2021
Researchers publishing in Cell Stem Cell have identified a protein that helps hematopoietic stem cells (HSCs) both in ex vivo cultures and in aging tissues. The problem with culturing cells
Senescent Cells and the Cytokine Storm
August 13, 2021
Research recently published in Aging shows how senescent cells overreact to inflammatory stimuli, causing them to excessively excrete compounds that promote inflammation. The researchers hypothesize that this is one cause
A New Clock Tracks Inflammatory Aging
August 12, 2021
Epigenetic clocks have become a mainstay of longevity research over the past few years, with new clocks regularly being established for different species and tissues as well as promising research
Dr. Aubrey de Grey Faces Allegations of Sexual Harassment
August 12, 2021
Early yesterday, LEAF became aware of allegations against Aubrey de Grey, the Chief Science Officer of the SENS Research Foundation, of sexual harassment. The allegations were raised by Laura Deming
Rejuvenation Roundup August 2021
September 1, 2021
August is over, and with it, our annual Ending Age-Related Diseases conference! EARD2021 was a great success, and we would like to thank our attendees and sponsors for their support. We will be releasing videos from this event over the coming months, so stay tuned. LEAF
What are Senolytics? A Summary of Senotherapeutics
September 1, 2021
In this article we will take a look at senolytics and how they have the potential to reverse some aspects of the aging process. Senescent cells and aging As your body ages, increasing amounts of your cells enter into a state of senescence. Senescent cells do
The Road Between Inflammation and Heart Aging
August 31, 2021
A team of Chinese researchers has outlined the cellular link between age-related inflammation (inflammaging) and the physical aging of heart muscle cells (cardiomyocytes). NLRP3 and why it matters We have previously discussed the NLRP3 inflammasome, which releases inflammatory cytokines upon exposure to irritants [1], including reactive
Early Antibiotic Exposure Can Decrease Lifespan in Mice
August 30, 2021
A study published in Cell Reports has shown that early-life exposure to antibiotics that destroy the gut flora can harm the lifelong development of mice, including lifespan. Three groups with different microbiota To begin the study, the researchers fed 20 baby mice, as well as their
DunedinPACE – A Next Generation Epigenetic Aging Clock
August 27, 2021
With so many health and disease outcomes connected to the biological aging processes, research into quantifying and tracking aging has surged in recent years due to the work of Steve Horvath, Morgan Levine, and others. Currently, epigenetic analysis of biological aging is thought to be the
What is Resveratrol? A Summary of Resveratrol
August 26, 2021
Probably best known for its presence in grapes and wine, this popular dietary supplement may have a few tricks up its sleeve. What is resveratrol? Resveratrol is a stilbenoid, a type of natural phenol. It is a phytoalexin, a growth-inhibiting substance created by plant tissues in
Collagen, Senescence, and Age-Related Hair Loss
August 25, 2021
Last week, a new study published in Aging reported similar mechanisms of TGF-ß2 and collagen on hair follicle aging, dermal papilla cell senescence, and in vitro spheroid formation. Aging hair follicles Hair follicles reside in the epidermal and dermal skin layers. At their base is the
Working the Deletion Problem out of CRISPR
August 24, 2021
In a study published in Genome Biology, researchers explain how they are working to make CRISPR less prone to large, accidental deletions of genetic material [1]. A previously unknown large problem While this seems counterintuitive, previous technology only allowed for the ready identification of deletions below
Stress, Sensory Gating, and Cognitive Decline With Age
August 23, 2021
Researchers publishing in Aging have found that stresses, both biological and in daily life, harm one of our fundamental abilities to correctly process what’s going on around us. What is sensory gating? Sensory gating is the brain’s ability to filter out irrelevant stimuli after the first
Longeveron Takes Aim at Aging with Cell Therapy
August 18, 2021
Longeveron has just announced the first data from its Phase 2b clinical trial that targets frailty with Lomecel-B, an MSC-based cell therapy. A longevity strategy built in More and more, biotech start-ups are applying longevity strategies to their therapeutic pipelines. Among them, Longeveron stands out as
The Hedgehog Protein Reduces Microglial Inflammation in Mice
August 17, 2021
Researchers, publishing in the journal Aging, have discovered that a protein called hedgehog alleviates the tissue-specific, age-related inflammation of the microglia, the maintenance cells of the brain. The aging differences between tissue types To begin this research, the team first performed a gene expression analysis on
Stem Cell Helper Heat Shock Protein Identified
August 16, 2021
Researchers publishing in Cell Stem Cell have identified a protein that helps hematopoietic stem cells (HSCs) both in ex vivo cultures and in aging tissues. The problem with culturing cells As the researchers explain, HSCs give rise to both red and white blood cells, making their
Senescent Cells and the Cytokine Storm
August 13, 2021
Research recently published in Aging shows how senescent cells overreact to inflammatory stimuli, causing them to excessively excrete compounds that promote inflammation. The researchers hypothesize that this is one cause of the cytokine storm, an immune overreaction that is more common in the elderly and is
A New Clock Tracks Inflammatory Aging
August 12, 2021
Epigenetic clocks have become a mainstay of longevity research over the past few years, with new clocks regularly being established for different species and tissues as well as promising research that uses and builds on these clocks. An international research team has recently created a different
Dr. Aubrey de Grey Faces Allegations of Sexual Harassment
August 12, 2021
Early yesterday, LEAF became aware of allegations against Aubrey de Grey, the Chief Science Officer of the SENS Research Foundation, of sexual harassment. The allegations were raised by Laura Deming (Longevity Fund) and Celine Halioua (biotech startup Loyal) – via their accounts on TwitÂter and personal