Category: News
What is Fisetin? A Summary of Fisetin
June 15, 2021
We take a look at the popular supplement fisetin and see how it stacks up as a potential anti-aging supplement. What is Fisetin? Fisetin is a plant polyphenol and part
Exercise Decreases Circulating Senescence Proteins
June 14, 2021
A new study published in Aging Cell shows that a 12-week program of structured exercise lowers the activity of the inflammatory SASP in people in their mid-60s. The expected results
Rapamycin Improves How Our DNA Is Stored
June 11, 2021
Researchers have demonstrated that rapamycin, a drug that has long been believed to slow down aging, changes the way DNA is stored inside cells to support gut health and longevity
Calico Scientists Develop Safer Cellular Reprogramming
June 11, 2021
In a preprint paper, scientists from Calico, Google’s longevity research behemoth, suggest that contrary to our previous understanding, transient reprogramming of cells using Yamanaka factors involves suppressing cellular identity, which
What is Apigenin? A Summary of Apigenin
June 10, 2021
This active ingredient in chamomile tea has traditionally been used to ease anxiety and reduce stress. We investigate if the scientific studies support this traditional use and how it relates
Who Wants to Live Forever?
June 10, 2021
A recent survey of adults in the US found that only about one-third would take a life extension pill if one were available [1]. These findings are about the same
The “Death is Inevitable, Why Bother?” Argument
June 10, 2021
It might be inevitable that everyone dies eventually, but that doesn’t actually matter as to whether or not rejuvenation is worth pursuing. Getting to the heart of this particular argument
Building Support for the War Against Aging
June 9, 2021
The life extension community has a number of long serving people in its ranks, and one of the longest-active of those in Russia is Mikhail Batin. His activities go way
COVID-19 Spike Protein Shown to Increase SASP
June 9, 2021
New research published in the journal Science has shown that the spike protein of SARS-CoV-2, the virus that causes COVID-19, causes senescent cells to secrete more of the senescence-associated secretory
Human Genome Fully Sequenced
June 8, 2021
In a preprint paper, scientists have announced the completion of the first full, telomere-to-telomere, sequencing of the human genome, more than two decades after the first draft of its sequencing.
The Two Kinds of p21 Expression
June 7, 2021
A team of researchers led by Dr. Judith Campisi of the Buck Institute has discovered valuable information about how cells express the senescence marker p21 [1]. Two genetic loci, one
Life Extension – Humanity or Individuals First?
June 5, 2021
What is it that really matters: preserving individual lives or preserving humanity? Is it more important to grant individuals the option to live as long as they’d like in good
Dr. Zalzala: PEARL Trial Could Advance the Longevity Field
June 3, 2021
We are very excited to be crowdfunding PEARL, one of the few human trials of rapamycin, which is probably the most promising anti-aging molecule known today. Dysregulation of nutrient sensing
Transcriptomic Aging Clock Measures More Than Just Age
June 3, 2021
Researchers have developed a new transcriptomic aging clock that incorporates information about biological pathways. With this approach, the clock predicts not only age but also how the state of various
Removing and Replacing Mitochondria in Human Cells
June 2, 2021
A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering
What is Fisetin? A Summary of Fisetin
June 15, 2021
We take a look at the popular supplement fisetin and see how it stacks up as a potential anti-aging supplement. What is Fisetin? Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. Â It is present in many trees and plants,
Exercise Decreases Circulating Senescence Proteins
June 14, 2021
A new study published in Aging Cell shows that a 12-week program of structured exercise lowers the activity of the inflammatory SASP in people in their mid-60s. The expected results To begin the study, participants were measured, weighed, tested on physical abilities, and asked about their
Rapamycin Improves How Our DNA Is Stored
June 11, 2021
Researchers have demonstrated that rapamycin, a drug that has long been believed to slow down aging, changes the way DNA is stored inside cells to support gut health and longevity [1]. This improvement to DNA storage has been observed in both fruit flies and mice in
Calico Scientists Develop Safer Cellular Reprogramming
June 11, 2021
In a preprint paper, scientists from Calico, Google’s longevity research behemoth, suggest that contrary to our previous understanding, transient reprogramming of cells using Yamanaka factors involves suppressing cellular identity, which may open the door to carcinogenic mutations. They also propose a milder reprogramming method inspired by
What is Apigenin? A Summary of Apigenin
June 10, 2021
This active ingredient in chamomile tea has traditionally been used to ease anxiety and reduce stress. We investigate if the scientific studies support this traditional use and how it relates to aging. What is apigenin? Apigenin is a very common and widely distributed flavonoid in the
Who Wants to Live Forever?
June 10, 2021
A recent survey of adults in the US found that only about one-third would take a life extension pill if one were available [1]. These findings are about the same as those of an Australian survey a decade ago [2], highlighting the need for more effective
The “Death is Inevitable, Why Bother?” Argument
June 10, 2021
It might be inevitable that everyone dies eventually, but that doesn’t actually matter as to whether or not rejuvenation is worth pursuing. Getting to the heart of this particular argument against life extension There’s a fundamental similarity between the questions “Why rejuvenate your body if it’s
Building Support for the War Against Aging
June 9, 2021
The life extension community has a number of long serving people in its ranks, and one of the longest-active of those in Russia is Mikhail Batin. His activities go way back to 2008 when the non-profit organization Science for Life Extension Foundation, which was first created
COVID-19 Spike Protein Shown to Increase SASP
June 9, 2021
New research published in the journal Science has shown that the spike protein of SARS-CoV-2, the virus that causes COVID-19, causes senescent cells to secrete more of the senescence-associated secretory phenotype (SASP), causing hyperinflammation and weakening the body’s defenses against viruses. An established link The researchers
Human Genome Fully Sequenced
June 8, 2021
In a preprint paper, scientists have announced the completion of the first full, telomere-to-telomere, sequencing of the human genome, more than two decades after the first draft of its sequencing. This was made possible by new sequencing technologies [1]. Mind the gaps The human genome was
The Two Kinds of p21 Expression
June 7, 2021
A team of researchers led by Dr. Judith Campisi of the Buck Institute has discovered valuable information about how cells express the senescence marker p21 [1]. Two genetic loci, one protein Cellular senescence is partially determined by two cyclin-dependent kinase inhibitor proteins: p16 and p21. The
Life Extension – Humanity or Individuals First?
June 5, 2021
What is it that really matters: preserving individual lives or preserving humanity? Is it more important to grant individuals the option to live as long as they’d like in good health, or is it more important to ensure the preservation of our species? This sort of
Dr. Zalzala: PEARL Trial Could Advance the Longevity Field
June 3, 2021
We are very excited to be crowdfunding PEARL, one of the few human trials of rapamycin, which is probably the most promising anti-aging molecule known today. Dysregulation of nutrient sensing (the ability of cells to adjust their metabolism to the amount of nutrients available) is thought
Transcriptomic Aging Clock Measures More Than Just Age
June 3, 2021
Researchers have developed a new transcriptomic aging clock that incorporates information about biological pathways. With this approach, the clock predicts not only age but also how the state of various genetic pathways changes with age, providing insight into the transcriptional changes involved in aging. Time for
Removing and Replacing Mitochondria in Human Cells
June 2, 2021
A new study conducted by a team of Japanese scientists and published in Scientific Reports details how cells can have their damaged mitochondria destroyed and replaced with healthy ones, offering a potential solution to the problem of mitochondrial dysfunction. Out with the old, in with the