Category: Supplements
Microglia Replacement Already Working in Humans
December 5, 2025
A new review highlights the promise of microglia replacement, a strategy that made the leap from mouse studies to the first successful human trial in just five years [1]. Repair
Engineering Immune Cells to Fight Gut Senescence
December 4, 2025
In Nature Aging, researchers have published their finding that targeting urokinase plasminogen activator receptor (uPAR), a senescence-associated protein, restores gut function in mice. One way the gut lining ages Of
Second-Hand Smoke Alters Protein Expression
December 3, 2025
A recent study investigated plasma proteins in people exposed to secondhand smoke and found that exposure affected multiple molecular processes, including immune, inflammatory, and tissue repair pathways [1]. Carrying the
Arginine Reduces Signs of Alzheimer’s in Mice
December 2, 2025
In a new study, the amino acid arginine shows promise in animal models of amyloid aggregation due to its ability to promote protein folding. The researchers suggest that it could
Rejuvenation Roundup November 2025
December 1, 2025
Many researchers in the United States have finished eating turkey and begun shopping, but their work continues. Here’s what people around the world have been doing to fight aging in
A Subtype of T Cells Counters Senescence in Mice
November 28, 2025
Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type of anti-senescence strategy
An AI-Based System Has Found a Potential Longevity Drug
November 27, 2025
In a preprint published in bioRxiv, Prof. Vadim Gladyshev and a team of researchers have used an artificial intelligence-based system to discover a wide variety of potential interventions, including a
The Roles of Phenylalanine and Tyrosine in Lifespan
November 26, 2025
A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data. The researchers reported an association between tyrosine and shorter lifespan, with
Fixing Lysosomes Improves Blood Stem Cell Function
November 25, 2025
In a recent study, scientists have demonstrated that lysosomal dysfunction actively decreases the potency of hematopoietic stem cells. Calming lysosomes reversed this process, opening avenues for new treatments [1]. Few
Nanoparticles Improve Intercellular Mitochondrial Transfer
November 24, 2025
Scientists have created “nanoflowers” that nudge donor cells to produce more mitochondria, which can then be transferred to recipient cells to boost their mitochondrial function [1]. Mitochondrial transfer is difficult
George Church on Building “Scientific Superintelligence”
November 21, 2025
George Church, a Harvard professor and a famed geroscientist, is also known as a serial entrepreneur who has co-founded dozens of biotech companies. While Church maintains that he’s involved in
How Senescent Cells Encourage Melanoma Growth
November 20, 2025
Researchers publishing in Aging Cell have documented a key reason why older people are much more likely to get melanoma. Why older people have significantly worse melanoma cases While melanoma
The Impact of Plant Polyphenols on Ovarian Aging
November 19, 2025
A recent review in the Journal of Ovarian Research summarizes current knowledge of the impact of various polyphenols on different aspects of ovarian aging. The researchers discuss that polyphenol supplementation
Vincere Biosciences Awarded $5 Million Grant
November 18, 2025
Cambridge, MA, USA – November 18, 2025: Vincere Biosciences today announced the receipt of a $5 million grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) through its
Improved Stem Cells Rejuvenate the Brains of Monkeys
November 18, 2025
Scientists have genetically modified human mesenchymal progenitor cells to express a more potent version of the “longevity gene” FOXO3, producing rejuvenative effects in monkeys, mice, and human cells [1]. Making
Microglia Replacement Already Working in Humans
December 5, 2025
A new review highlights the promise of microglia replacement, a strategy that made the leap from mouse studies to the first successful human trial in just five years [1]. Repair or replace Microglia, the resident immune cells of the brain, have been implicated in various diseases, including Alzheimer’s [2]. However,
Engineering Immune Cells to Fight Gut Senescence
December 4, 2025
In Nature Aging, researchers have published their finding that targeting urokinase plasminogen activator receptor (uPAR), a senescence-associated protein, restores gut function in mice. One way the gut lining ages Of all the tissues in the human body, the intestinal epithelium, which lines the gut, replaces its cells most quickly [1].
Second-Hand Smoke Alters Protein Expression
December 3, 2025
A recent study investigated plasma proteins in people exposed to secondhand smoke and found that exposure affected multiple molecular processes, including immune, inflammatory, and tissue repair pathways [1]. Carrying the consequences of something you didn’t do It is widely known and researched that smoking is bad for health, and there
Arginine Reduces Signs of Alzheimer’s in Mice
December 2, 2025
In a new study, the amino acid arginine shows promise in animal models of amyloid aggregation due to its ability to promote protein folding. The researchers suggest that it could be useful for early prevention and treatment of Alzheimer’s [1]. Hold it and fold it Amino acids, the building blocks
Rejuvenation Roundup November 2025
December 1, 2025
Many researchers in the United States have finished eating turkey and begun shopping, but their work continues. Here’s what people around the world have been doing to fight aging in November. Interviews George Church on Building “Scientific Superintelligence”: This involves creating an array of AI models and building huge robotic
A Subtype of T Cells Counters Senescence in Mice
November 28, 2025
Scientists have discovered that a cytotoxic subtype of CD4 T cells, which is enriched in old people, helps control cellular senescence. This hints at a new type of anti-senescence strategy but also suggests that an immune system can be “overly youthful.” When generals become fighters CD4 T cells usually behave
An AI-Based System Has Found a Potential Longevity Drug
November 27, 2025
In a preprint published in bioRxiv, Prof. Vadim Gladyshev and a team of researchers have used an artificial intelligence-based system to discover a wide variety of potential interventions, including a drug that significantly improves biomarkers of frailty in mice. Repurposing previous data Previous research efforts have created a massive dataset
The Roles of Phenylalanine and Tyrosine in Lifespan
November 26, 2025
A recent study investigated the impact of two amino acids, phenylalanine and tyrosine, on lifespan using UK Biobank data. The researchers reported an association between tyrosine and shorter lifespan, with sex-specific differences. The results for phenylalanine were more inconsistent [1]. One by one Model animal research has shown that protein
Fixing Lysosomes Improves Blood Stem Cell Function
November 25, 2025
In a recent study, scientists have demonstrated that lysosomal dysfunction actively decreases the potency of hematopoietic stem cells. Calming lysosomes reversed this process, opening avenues for new treatments [1]. Few and far between Hematopoietic stem cells (HSCs) are rare and precious: they produce blood progenitor cells, which, in turn, produce
Nanoparticles Improve Intercellular Mitochondrial Transfer
November 24, 2025
Scientists have created “nanoflowers” that nudge donor cells to produce more mitochondria, which can then be transferred to recipient cells to boost their mitochondrial function [1]. Mitochondrial transfer is difficult to improve Energy is required for life, and most energy in our cells is produced by mitochondria. When these organelles
George Church on Building “Scientific Superintelligence”
November 21, 2025
George Church, a Harvard professor and a famed geroscientist, is also known as a serial entrepreneur who has co-founded dozens of biotech companies. While Church maintains that he’s involved in them all, one company has been seeing an unusual amount of his attention: Lila Sciences, where he assumed the role
How Senescent Cells Encourage Melanoma Growth
November 20, 2025
Researchers publishing in Aging Cell have documented a key reason why older people are much more likely to get melanoma. Why older people have significantly worse melanoma cases While melanoma is much more treatable now than in the past, it still remains a serious danger. Melanoma can develop resistance to
The Impact of Plant Polyphenols on Ovarian Aging
November 19, 2025
A recent review in the Journal of Ovarian Research summarizes current knowledge of the impact of various polyphenols on different aspects of ovarian aging. The researchers discuss that polyphenol supplementation could be used as an intervention to delay ovarian aging [1]. Every woman’s problem Ovarian aging and cessation of proper
Vincere Biosciences Awarded $5 Million Grant
November 18, 2025
Cambridge, MA, USA – November 18, 2025: Vincere Biosciences today announced the receipt of a $5 million grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) through its Therapeutics Pipeline Program, which supports the advancement of promising therapies through preclinical and clinical stages. The initiative focuses on candidates
Improved Stem Cells Rejuvenate the Brains of Monkeys
November 18, 2025
Scientists have genetically modified human mesenchymal progenitor cells to express a more potent version of the “longevity gene” FOXO3, producing rejuvenative effects in monkeys, mice, and human cells [1]. Making aging-resistant cells Stem cell exhaustion is one of the mechanisms of aging. Replenishing the aging stem cell pool with new