Category: News
Well-Known Researchers Discuss Personalized Aging Treatments
May 15, 2025
The Hallmarks of Aging team has returned to Cell, publishing a detailed review discussing how future methods of dealing with aging might be highly personalized. Two more hallmarks? In the
How Apigenin May Reduce Senescence and Cancer
May 14, 2025
Screening of a natural compounds library has revealed the senomorphic properties of apigenin. This natural flavonoid also demonstrated rejuvenating effects on many aging-associated molecular features as well as physical and
Gamma Delta T Cells Show Promise Against Cellular Senescence
May 13, 2025
Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis [1].
A New Approach to Treating Aging Skin
May 12, 2025
Researchers publishing in Aging Cell have found a biochemical pathway that leads skin cells to become senescent along with a potential target for future therapies. Fibroblasts have a purpose Dermal
Michael Levin on Bioelectricity in Development and Aging
May 8, 2025
Michael Levin, professor at Tufts University and director of Allen Discovery Center, has been working for years on how bioelectrical patterns affect development and aging. His research proves that this
Young Microbiota Transfer Reduces Aging Aspects in Mice
May 7, 2025
In a recent study, lifelong, repeated microbiota transfer from young mice to old mice improves intestinal permeability, coordinative ability, and metabolic profiles while reducing pro-inflammatory responses [1]. Small in size,
TFEB Lets Cells Live Long Enough to Become Senescent
May 6, 2025
In Aging Cell, researchers have explained how transcription factor EB (TFEB) is related to cellular senescence and keeps stressed cells alive. Inactivated by mTOR Yesterday, we reported on TFEB’s effects
Limiting One Protein Maintenance Pathway Enhances Another
May 5, 2025
In Aging Cell, researchers have explored how transcription factor EB (TFEB) promotes proteostasis in a common aging model. Maintaining protein function Proteostasis is naturally maintained by a quality control system
Playing the Long Game Towards Radical Life Extension
May 1, 2025
For most of the history of human civilization, humanity expanded at an astonishing pace: faster than exponential, nearly hyperbolic. This trend was famously described in a 1960 paper by Heinz
Rejuvenation Roundup April 2025
May 1, 2025
While computer technology continues to accelerate, human beings still have to contend with age-related disease and death. Here’s some of what’s been done to support longer, healthier lives in April.
Impact of Butter and Plant-Based Oils on Mortality
April 30, 2025
A study published in JAMA Internal Medicine suggests that a higher intake of butter is associated with increased mortality while a higher intake of plant-based oils is associated with reduced
Immune Resilience Is a Strong Determinant of Mortality
April 29, 2025
A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to
How Extracellular Vesicles From Stem Cells Fight Senescence
April 28, 2025
Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. A new approach to
OS-01 Peptide Tested in Skin Aging Pilot Study
April 25, 2025
A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the
How Fisetin May Fight Blood Vessel Calcification
April 24, 2025
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. When calcium goes where
Well-Known Researchers Discuss Personalized Aging Treatments
May 15, 2025
The Hallmarks of Aging team has returned to Cell, publishing a detailed review discussing how future methods of dealing with aging might be highly personalized. Two more hallmarks? In the original and very heavily cited 2013 paper [1], Dr. López-OtÃn and colleagues outlined nine hallmarks of
How Apigenin May Reduce Senescence and Cancer
May 14, 2025
Screening of a natural compounds library has revealed the senomorphic properties of apigenin. This natural flavonoid also demonstrated rejuvenating effects on many aging-associated molecular features as well as physical and cognitive performance, and it has a beneficial impact on cancer treatment in mice and cells [1].
Gamma Delta T Cells Show Promise Against Cellular Senescence
May 13, 2025
Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis [1]. How do we harness the immune system against senescence? Cellular senescence, which occurs when cells subjected
A New Approach to Treating Aging Skin
May 12, 2025
Researchers publishing in Aging Cell have found a biochemical pathway that leads skin cells to become senescent along with a potential target for future therapies. Fibroblasts have a purpose Dermal fibroblasts are common subjects in aging research, particularly in the context of senescence. These cells have
Michael Levin on Bioelectricity in Development and Aging
May 8, 2025
Michael Levin, professor at Tufts University and director of Allen Discovery Center, has been working for years on how bioelectrical patterns affect development and aging. His research proves that this often-overlooked part of biology is immensely important and that mastering its mechanisms might one day do
Young Microbiota Transfer Reduces Aging Aspects in Mice
May 7, 2025
In a recent study, lifelong, repeated microbiota transfer from young mice to old mice improves intestinal permeability, coordinative ability, and metabolic profiles while reducing pro-inflammatory responses [1]. Small in size, but mighty in impact Previous research has found that the composition and function of gut microbes
TFEB Lets Cells Live Long Enough to Become Senescent
May 6, 2025
In Aging Cell, researchers have explained how transcription factor EB (TFEB) is related to cellular senescence and keeps stressed cells alive. Inactivated by mTOR Yesterday, we reported on TFEB’s effects on proteostasis and how it has downstream functions on protein chaperones. This research, however, focuses on
Limiting One Protein Maintenance Pathway Enhances Another
May 5, 2025
In Aging Cell, researchers have explored how transcription factor EB (TFEB) promotes proteostasis in a common aging model. Maintaining protein function Proteostasis is naturally maintained by a quality control system that utilizes a network of chaperones and co-chaperones in order to handle all aspects of protein
Playing the Long Game Towards Radical Life Extension
May 1, 2025
For most of the history of human civilization, humanity expanded at an astonishing pace: faster than exponential, nearly hyperbolic. This trend was famously described in a 1960 paper by Heinz von Foerster and colleagues, who extrapolated global population data to predict a so-called “Doomsday”, a demographic
Rejuvenation Roundup April 2025
May 1, 2025
While computer technology continues to accelerate, human beings still have to contend with age-related disease and death. Here’s some of what’s been done to support longer, healthier lives in April. A Lifespan.io Project Bears Fruit Results of a Crowdfunded One-Year Human Rapamycin Trial: In Aging, Dr.
Impact of Butter and Plant-Based Oils on Mortality
April 30, 2025
A study published in JAMA Internal Medicine suggests that a higher intake of butter is associated with increased mortality while a higher intake of plant-based oils is associated with reduced mortality [1]. Fats: the good, the bad, and the ugly Previous research has found that not all
Immune Resilience Is a Strong Determinant of Mortality
April 29, 2025
A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to withstand stress [1]. Keeping the balance Geroscientists have long suspected that the immune system plays an
How Extracellular Vesicles From Stem Cells Fight Senescence
April 28, 2025
Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. A new approach to senescence The researchers began their paper discussing the well-trodden ground of senolytics, which kill senescent cells,
OS-01 Peptide Tested in Skin Aging Pilot Study
April 25, 2025
A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the skin’s barrier function and multiple aging biomarkers [1]. Conducted by a team from OneSkin alongside academic
How Fisetin May Fight Blood Vessel Calcification
April 24, 2025
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. When calcium goes where it doesn’t belong Calcification is not the same as ‘hardening’ of blood vessel walls (atherosclerosis), which