Category: News
Researchers Identify a New Dementia Target
June 30, 2025
Researchers have ascertained that excessive amounts of complement C3, an essential immune protein that increases with aging, are responsible for causing dementia in a mouse model. A necessary complement The
Subcutaneous and Visceral Fat React Differently to Obesity
June 27, 2025
Scientists have found that visceral fat and subcutaneous fat produce different responses to obesity in male mice and human patients and identified an important regulator of these processes [1]. The
How Part of the Krebs Cycle Affects Senescence
June 26, 2025
Researchers have discovered how and why α-ketoglutaric acid (AKG) affects cellular senescence and how a small molecule may be useful in affecting this process. They published their findings in Cell
Targeting an Inflammatory Pathway Fights Alzheimer’s
June 25, 2025
Scientists have discovered that a rare mutation protects against Alzheimer’s disease by dampening a central inflammatory pathway. They recapitulated these results using a small molecule [1]. The woman who beat
Lipid Metabolite Rejuvenates Muscle Stem Cells in Mice
June 24, 2025
A recent study investigated the effect of a single treatment of prostaglandin E2 on improving muscle strength and rejuvenating muscle stem cells in mice. The researchers explored the molecular and
Senolytics May Treat Some Long-Term Viral Lung Damage
June 23, 2025
In Aging Cell, researchers have published their findings that mice exposed to influenza experience long-term consequences that can be partially ameliorated with senolytics. Post-viral syndromes Long before the spread of
Longevity Policy, Advocacy in the Spotlight at Vitalist Bay
June 20, 2025
Just several years ago, longevity conferences were few and far between. Today, there’s no shortage of them. Happening regularly around the globe, they foster scientific debate and showcase geroscience advances
Engineering Microglia to Deliver an Anti-Alzheimer’s Drug
June 19, 2025
In Cell Stem Cell, researchers have described how genetically engineered microglia can be used to deliver therapeutic proteins to the brain. The blood-brain barrier Delivering therapeutic compounds to the brain
Longer Reproductive Spans Linked to Younger Brains in Women
June 18, 2025
Analysis of over a thousand postmenopausal women suggests that women with longer reproductive spans, earlier first period (menarche), and later menopause experience slower brain aging [1]. Linking sex hormones to
Financial Behavior Might Help Diagnose Dementia Early
June 17, 2025
By analyzing a large UK dataset, scientists have identified various financial behaviors that might point to dementia years before it leads to loss of financial capacity [1]. The money trail
A New Method of Modifying Stem Cells
June 16, 2025
Researchers have investigated a never-before-used method of transfecting senescent mesenchymal stem cells (MSCs) and published their results In the Cell journal Molecular Therapy Nucleic Acids. Detergents for gene therapy Altering
A Popular Sweetener Adversely Affects Blood Vessels
June 13, 2025
A new study has lent more support to previous epidemiological data that ties the popular sugar substitute erythritol to elevated cardiovascular risk [1]. Deceptively sweet Sugar substitutes have been around
Preventing CRISPR From Causing Senescence
June 12, 2025
Researchers publishing in Cell Reports Medicine have taken a look at what causes CRISPR/Cas9 gene-editing technology to drive cells senescent and investigated a potential method of preventing it. Breaking and
How Gut Microbiota Impact Endothelial Cell Senescence
June 11, 2025
In a recent study that included data from humans, mice, and cell culture experiments, researchers demonstrated that gut microbes and their metabolites can profoundly influence the senescence of endothelial cells.
New Study Could Pave the Way for Better Cancer Vaccines
June 10, 2025
Scientists have found that only about 1% of presented tumor antigens come from oncogenic mutations. The remaining 99%, previously overlooked, may offer better treatment targets [1]. Going after mutations Cancer
Researchers Identify a New Dementia Target
June 30, 2025
Researchers have ascertained that excessive amounts of complement C3, an essential immune protein that increases with aging, are responsible for causing dementia in a mouse model. A necessary complement The complement system is a key immune system component that is involved in removing misfolded proteins, infectious
Subcutaneous and Visceral Fat React Differently to Obesity
June 27, 2025
Scientists have found that visceral fat and subcutaneous fat produce different responses to obesity in male mice and human patients and identified an important regulator of these processes [1]. The tale of the two fats It has been known that visceral fat, which accumulates around organs
How Part of the Krebs Cycle Affects Senescence
June 26, 2025
Researchers have discovered how and why α-ketoglutaric acid (AKG) affects cellular senescence and how a small molecule may be useful in affecting this process. They published their findings in Cell Reports. A crucial molecule AKG is a major part of multiple fundamental metabolic processes, including the
Targeting an Inflammatory Pathway Fights Alzheimer’s
June 25, 2025
Scientists have discovered that a rare mutation protects against Alzheimer’s disease by dampening a central inflammatory pathway. They recapitulated these results using a small molecule [1]. The woman who beat the odds For the last 40 years, scientists have been studying a massive extended family of
Lipid Metabolite Rejuvenates Muscle Stem Cells in Mice
June 24, 2025
A recent study investigated the effect of a single treatment of prostaglandin E2 on improving muscle strength and rejuvenating muscle stem cells in mice. The researchers explored the molecular and epigenetic aspects underlying this rejuvenation [1]. Aging muscle stem cells Sarcopenia, a loss of skeletal muscle
Senolytics May Treat Some Long-Term Viral Lung Damage
June 23, 2025
In Aging Cell, researchers have published their findings that mice exposed to influenza experience long-term consequences that can be partially ameliorated with senolytics. Post-viral syndromes Long before the spread of the SARS-CoV-2 virus that causes COVID-19, it had been well-established that viral lung diseases such as
Longevity Policy, Advocacy in the Spotlight at Vitalist Bay
June 20, 2025
Just several years ago, longevity conferences were few and far between. Today, there’s no shortage of them. Happening regularly around the globe, they foster scientific debate and showcase geroscience advances to the world while energetically discussing longevity biotech and regulations. However, one important subfield, working with
Engineering Microglia to Deliver an Anti-Alzheimer’s Drug
June 19, 2025
In Cell Stem Cell, researchers have described how genetically engineered microglia can be used to deliver therapeutic proteins to the brain. The blood-brain barrier Delivering therapeutic compounds to the brain has a concern that is absent for other organs: the blood-brain barrier (BBB), which retains strict
Longer Reproductive Spans Linked to Younger Brains in Women
June 18, 2025
Analysis of over a thousand postmenopausal women suggests that women with longer reproductive spans, earlier first period (menarche), and later menopause experience slower brain aging [1]. Linking sex hormones to brain health The female reproductive system fails to work properly much earlier than other systems in
Financial Behavior Might Help Diagnose Dementia Early
June 17, 2025
By analyzing a large UK dataset, scientists have identified various financial behaviors that might point to dementia years before it leads to loss of financial capacity [1]. The money trail Alzheimer’s disease and related dementias remain a particularly hard nut for scientists to crack. One commonly
A New Method of Modifying Stem Cells
June 16, 2025
Researchers have investigated a never-before-used method of transfecting senescent mesenchymal stem cells (MSCs) and published their results In the Cell journal Molecular Therapy Nucleic Acids. Detergents for gene therapy Altering the genetics of a living person is much trickier than altering them in cells in a
A Popular Sweetener Adversely Affects Blood Vessels
June 13, 2025
A new study has lent more support to previous epidemiological data that ties the popular sugar substitute erythritol to elevated cardiovascular risk [1]. Deceptively sweet Sugar substitutes have been around for decades, and while some people have reported decreases in weight and blood glucose, a growing
Preventing CRISPR From Causing Senescence
June 12, 2025
Researchers publishing in Cell Reports Medicine have taken a look at what causes CRISPR/Cas9 gene-editing technology to drive cells senescent and investigated a potential method of preventing it. Breaking and repairing DNA Genetic engineering of living cells through CRISPR/Cas9 technology requires three things to occur. The
How Gut Microbiota Impact Endothelial Cell Senescence
June 11, 2025
In a recent study that included data from humans, mice, and cell culture experiments, researchers demonstrated that gut microbes and their metabolites can profoundly influence the senescence of endothelial cells. They also explored the molecular processes underlying these changes [1]. Senescence in the blood vessels Endothelial
New Study Could Pave the Way for Better Cancer Vaccines
June 10, 2025
Scientists have found that only about 1% of presented tumor antigens come from oncogenic mutations. The remaining 99%, previously overlooked, may offer better treatment targets [1]. Going after mutations Cancer arises from a series of mutations that drive abnormal cellular behaviors, such as runaway proliferation. Cancerous