Category: News
Short-Term Overeating Alters Brain Insulin Sensitivity
March 18, 2025
A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in
Elamipretide, a Potential New Drug, Reduces Frailty in Mice
March 17, 2025
In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to
Using a Surface Biomarker to Target Senescent Cells
March 14, 2025
Scientists have identified a senescence-associated surface protein that can be targeted using antibodies [1]. This discovery might help distinguish between beneficial and harmful senescent cells and could speed up the development
Cellular Senescence Prevents Unlearning in Some Male Mice
March 13, 2025
In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. Resilience versus decline The authors begin their paper by noting that cognitive
How Life Expectancy Has Changed in Europe
March 12, 2025
A recent country-level analysis of life expectancy among several European nations shows changes in life expectancy trends and how well-designed national policies can reduce or minimize exposure to risk factors,
A New Study Claims to Challenge Peto’s Paradox
March 11, 2025
Applying statistical methods to a large dataset spanning almost 300 species, scientists found a positive correlation between body size and cancer prevalence [1]. Other researchers dispute that these findings invalidate
An Existing Diabetes Drug May Treat Aspects of Aging
March 10, 2025
In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence
A Klotho Gene Therapy Extends Life in Male Mice
March 6, 2025
In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads
Ginkgolide B Improves Healthspan and Lifespan in Female Mice
March 5, 2025
The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice
Genes Affect Aging and Mortality Less Than Extrinsic Factors
March 4, 2025
A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of
Rejuvenation Roundup February 2025
March 3, 2025
February might be the shortest month of the year, but it still has room for plenty of research and advancements. Here’s what’s happened over the last four weeks. Interviews Junevity
A Protein That Controls Senescent Cell Structure
February 28, 2025
Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Stress fibers naturally hold cells into their proper shape.
Junevity Is Silencing RNA to Treat Obesity and Diabetes
February 27, 2025
Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from
Effects of Estradiol and Progesterone on Knee Osteoarthritis
February 26, 2025
Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint
Receiving Care in Your Language Linked to Lower Health Risks
February 25, 2025
A new study suggests that people with hypertension who receive care in their preferred language are less likely to have a major cardiovascular event or die from any cause [1].
Short-Term Overeating Alters Brain Insulin Sensitivity
March 18, 2025
A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in obesity and type 2 diabetes [1]. What can go wrong in five days? If you usually
Elamipretide, a Potential New Drug, Reduces Frailty in Mice
March 17, 2025
In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to the clinic As a mitochondria-affecting antioxidant peptide, elamipretide has been, and continues to be, the subject
Using a Surface Biomarker to Target Senescent Cells
March 14, 2025
Scientists have identified a senescence-associated surface protein that can be targeted using antibodies [1]. This discovery might help distinguish between beneficial and harmful senescent cells and could speed up the development of senolytic therapies. This work was done by the Lifespan Research Institute, which was formed last
Cellular Senescence Prevents Unlearning in Some Male Mice
March 13, 2025
In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. Resilience versus decline The authors begin their paper by noting that cognitive decline in older people varies greatly. Some people suffer serious cognitive defects; other people are scarcely
How Life Expectancy Has Changed in Europe
March 12, 2025
A recent country-level analysis of life expectancy among several European nations shows changes in life expectancy trends and how well-designed national policies can reduce or minimize exposure to risk factors, thus improving life expectancy [1]. Slowdown in life expectancy increase Life expectancy has grown in high-income
A New Study Claims to Challenge Peto’s Paradox
March 11, 2025
Applying statistical methods to a large dataset spanning almost 300 species, scientists found a positive correlation between body size and cancer prevalence [1]. Other researchers dispute that these findings invalidate the famous paradox. A paradox of size Cancer has forever been a mortal enemy of multicellular
An Existing Diabetes Drug May Treat Aspects of Aging
March 10, 2025
In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence in mice. A system tightly tied together This paper begins with a discussion of the relationship
A Klotho Gene Therapy Extends Life in Male Mice
March 6, 2025
In Molecular Therapy, a team of researchers has described how increasing the expression of a form of Klotho, a protein that has been frequently found to have rejuvenative effects, leads to longer lifespans in male mice. Klotho has various forms In their introduction, the researchers distinguish
Ginkgolide B Improves Healthspan and Lifespan in Female Mice
March 5, 2025
The authors of a recent study describe Ginkgolide B, a compound with senotherapeutic potential that improved muscle health, metabolism, frailty, inflammation, and senescence metrics and increased lifespan in female mice [1]. From East Asia to the clinic Ginkgolide B is a compound that can be extracted
Genes Affect Aging and Mortality Less Than Extrinsic Factors
March 4, 2025
A massive study from the University of Oxford has evaluated the relative impact of genetic and non-genetic factors on aging, mortality, and disease prevalence. A deeper dive The question of how strongly genes affect our longevity has been asked before, and the emerging answer is not
Rejuvenation Roundup February 2025
March 3, 2025
February might be the shortest month of the year, but it still has room for plenty of research and advancements. Here’s what’s happened over the last four weeks. Interviews Junevity Is Silencing RNA to Treat Obesity and Diabetes: Some longevity biotech companies fit neatly into one
A Protein That Controls Senescent Cell Structure
February 28, 2025
Researchers publishing in Cellular Signaling have explained how the protein AP2A1 affects stress fibers that change with cellular senescence. Stress fibers Stress fibers naturally hold cells into their proper shape. They are made out of the common protein actin and linked together by α-actinin and a
Junevity Is Silencing RNA to Treat Obesity and Diabetes
February 27, 2025
Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from the University of California, San Francisco, dare to walk an unbeaten path. Junevity pursues the ambitious
Effects of Estradiol and Progesterone on Knee Osteoarthritis
February 26, 2025
Recent research has addressed menopause-related molecular processes that impact the high prevalence of knee osteoarthritis in post-menopausal women. Restoration of female sex hormones in a post-menopausal mouse model improved joint health [1]. A centuries-old observation The authors start the article with a quote from the English
Receiving Care in Your Language Linked to Lower Health Risks
February 25, 2025
A new study suggests that people with hypertension who receive care in their preferred language are less likely to have a major cardiovascular event or die from any cause [1]. Let’s find a common language Communication between the doctor and the patient is important, and it