Category: News
Playing the Long Game Towards Radical Life Extension
May 1, 2025
For most of the history of human civilization, humanity expanded at an astonishing pace: faster than exponential, nearly hyperbolic. This trend was famously described in a 1960 paper by Heinz
Rejuvenation Roundup April 2025
May 1, 2025
While computer technology continues to accelerate, human beings still have to contend with age-related disease and death. Here’s some of what’s been done to support longer, healthier lives in April.
Impact of Butter and Plant-Based Oils on Mortality
April 30, 2025
A study published in JAMA Internal Medicine suggests that a higher intake of butter is associated with increased mortality while a higher intake of plant-based oils is associated with reduced
Immune Resilience Is a Strong Determinant of Mortality
April 29, 2025
A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to
How Extracellular Vesicles From Stem Cells Fight Senescence
April 28, 2025
Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. A new approach to
OS-01 Peptide Tested in Skin Aging Pilot Study
April 25, 2025
A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the
How Fisetin May Fight Blood Vessel Calcification
April 24, 2025
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. When calcium goes where
Technology Use Associated With Reduced Cognitive Impairment
April 23, 2025
New research suggests that digital technologies provide beneficial effects on cognition in middle-aged and older adults who did not grow up with such technologies [1]. Childhood without computers For younger
Researchers Fight Some Mutations by Targeting Mitochondria
April 22, 2025
Clonal hematopoiesis, a condition linked to numerous age-related disorders, can be caused by overachieving mitochondria, and it may be susceptible to drugs such as MitoQ and metformin [1]. The attack
A Senescence-Related Target for Blood Vessel Formation
April 21, 2025
In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. Macrophages
Researchers Use Big Data to Find a Longevity Target
April 16, 2025
Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk, finding a new potential target in the process. Putting
Senolytics Decrease Low Back Pain in Mice
April 15, 2025
Researchers have tested a synthetic and natural senolytic combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration. They observed reduced signs of back pain;
Results of a Crowdfunded One-Year Human Rapamycin Trial
April 14, 2025
In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was
Neurons Hidden to Immune Cells Improve Parkinson’s in Rats
April 11, 2025
By tweaking genes used by placental and cancerous cells to evade immune detection, scientists have created non-immunogenic neuronal grafts that may help Parkinson’s patients [1]. Sneakiness needed In recent years,
How Exercise May Fight Parkinson’s Disease
April 10, 2025
Experimenting on rodents, researchers have found a pathway through which exercise could fight Parkinson’s disease and a molecule that might recapitulate this effect. Fighting inflammation is crucial in Parkinson’s Parkinson’s
Playing the Long Game Towards Radical Life Extension
May 1, 2025
For most of the history of human civilization, humanity expanded at an astonishing pace: faster than exponential, nearly hyperbolic. This trend was famously described in a 1960 paper by Heinz von Foerster and colleagues, who extrapolated global population data to predict a so-called “Doomsday”, a demographic
Rejuvenation Roundup April 2025
May 1, 2025
While computer technology continues to accelerate, human beings still have to contend with age-related disease and death. Here’s some of what’s been done to support longer, healthier lives in April. A lifespan.io Project Bears Fruit Results of a Crowdfunded One-Year Human Rapamycin Trial: In Aging, Dr.
Impact of Butter and Plant-Based Oils on Mortality
April 30, 2025
A study published in JAMA Internal Medicine suggests that a higher intake of butter is associated with increased mortality while a higher intake of plant-based oils is associated with reduced mortality [1]. Fats: the good, the bad, and the ugly Previous research has found that not all
Immune Resilience Is a Strong Determinant of Mortality
April 29, 2025
A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to withstand stress [1]. Keeping the balance Geroscientists have long suspected that the immune system plays an
How Extracellular Vesicles From Stem Cells Fight Senescence
April 28, 2025
Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. A new approach to senescence The researchers began their paper discussing the well-trodden ground of senolytics, which kill senescent cells,
OS-01 Peptide Tested in Skin Aging Pilot Study
April 25, 2025
A recent study featured in the Journal of Cosmetic Dermatology has analyzed the impact of a topical product containing OS-01. This is a senotherapeutic peptide that targets senescence, affecting the skin’s barrier function and multiple aging biomarkers [1]. Conducted by a team from OneSkin alongside academic
How Fisetin May Fight Blood Vessel Calcification
April 24, 2025
In Aging, researchers have described how the well-known supplement fisetin may fight calcification of the blood vessels, seeing significant successes in both cellular and mouse models. When calcium goes where it doesn’t belong Calcification is not the same as ‘hardening’ of blood vessel walls (atherosclerosis), which
Technology Use Associated With Reduced Cognitive Impairment
April 23, 2025
New research suggests that digital technologies provide beneficial effects on cognition in middle-aged and older adults who did not grow up with such technologies [1]. Childhood without computers For younger people, it is difficult to imagine living in a world without the internet and digital technologies.
Researchers Fight Some Mutations by Targeting Mitochondria
April 22, 2025
Clonal hematopoiesis, a condition linked to numerous age-related disorders, can be caused by overachieving mitochondria, and it may be susceptible to drugs such as MitoQ and metformin [1]. The attack of the clones The human body constantly produces vast numbers of blood cells from hematopoietic stem
A Senescence-Related Target for Blood Vessel Formation
April 21, 2025
In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. Macrophages can impair blood vessel formation Heart attack and stroke are not the only problems caused by
Researchers Use Big Data to Find a Longevity Target
April 16, 2025
Researchers publishing in Aging Cell have used large databases to discover a causal relationship between multiple genes and overall mortality risk, finding a new potential target in the process. Putting -omics databases to work These researchers introduce their study by discussing genetic databases, which have previously
Senolytics Decrease Low Back Pain in Mice
April 15, 2025
Researchers have tested a synthetic and natural senolytic combination of RG-7112 and o-vanillin in mice with early-onset low back pain and disc degeneration. They observed reduced signs of back pain; decreased senescence and disc degeneration; and improvements in vertebral bone quality [1]. A painful global problem
Results of a Crowdfunded One-Year Human Rapamycin Trial
April 14, 2025
In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was crowdfunded by lifespan.io. Crowdfunded research bears fruit Four years ago, in collaboration with AgelessRx, lifespan.io crowdfunded
Neurons Hidden to Immune Cells Improve Parkinson’s in Rats
April 11, 2025
By tweaking genes used by placental and cancerous cells to evade immune detection, scientists have created non-immunogenic neuronal grafts that may help Parkinson’s patients [1]. Sneakiness needed In recent years, scientists have learned to produce cells via cellular reprogramming, a process in which differentiated cells are
How Exercise May Fight Parkinson’s Disease
April 10, 2025
Experimenting on rodents, researchers have found a pathway through which exercise could fight Parkinson’s disease and a molecule that might recapitulate this effect. Fighting inflammation is crucial in Parkinson’s Parkinson’s disease is characterized by Lewy bodies and the loss of dopaminergic neurons [1]. Recent work has