Category: News
Restoring Cellular Proliferation Through Exosomes
January 27, 2025
In Cell Metabolism, researchers have described how a microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) restores function and fights senescence in cell cultures and mice.
New Drug Eliminates Breast Cancer in Mouse Study
January 24, 2025
Researchers have discovered a small molecule that effectively kills cancer cells in the most prevalent type of breast cancer. The new drug could help against cancer recurrence and decrease the
Marco Quarta on Cellular Senescence in Aging
January 24, 2025
Dr. Marco Quarta runs one of the most interesting start-ups in the longevity field: Rubedo, which focuses on utilizing the senolytic approach to cellular senescence. This company has developed ingenious
Maintaining Muscle by Restoring Gut Bacteria
January 23, 2025
In Aging Cell, researchers have described how different combinations of gut bacteria impact muscle strength in mice. Expanding upon a known link The link between gut bacteria and health is
Cyclarity Launches Human Trial to Cure Atherosclerosis
January 23, 2025
Recently, Cyclarity Therapeutics announced the launch of a Phase 1 human clinical trial for a drug that aims to remove the arterial plaques that lead to heart attacks and strokes.
Maintaining Telomeres Extends Lifespan in Mice
January 22, 2025
A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, leads to lifespan extension in
Fighting Alzheimer’s by Helping Neurons Consume Proteins
January 21, 2025
Researchers have found that kinesin family member 9 (KIF9), a protein that diminishes with aging, is instrumental in allowing cells to consume harmful proteins and fights Alzheimer’s in a mouse
New Study Links Epigenetic Changes to Genetic Mutations
January 21, 2025
A new paper published in Nature Aging suggests that somatic mutations cause significant remodeling of the epigenetic landscape. The findings might be relevant to future anti-aging interventions [1]. The genome
The Battle for Long Life Has Been Accomplished: What’s Next?
January 20, 2025
How long can people live? This is not just a foundational question in science. The answer has important public policy implications and is of interest to us all. Recent scientific
Enhancing NAD+ Efficiency by Energizing Sirtuins
January 16, 2025
Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+. Looking for a new way to boost enzymes The
The Impact of a Human Breast Milk Probiotic on Sarcopenia
January 15, 2025
A recent study linked probiotic-induced gut microbiome and metabolite changes to improved muscle functioning in older sarcopenia patients [1]. Sarcopenia and the gut Sarcopenia is an age-related condition. People with
A Gut Metabolite Reduces Senescence and Inflammation
January 14, 2025
In a preprint study, scientists from Lifespan Research Institute and the Buck Institute for Research on Aging have published their findings that Urolithin A, a molecule that has garnered a
Cyclarity Launches Human Trial for Atherosclerosis
January 13, 2025
Cyclarity Therapeutics, a biotechnology company based at the Buck Institute in California, has launched its first human clinical trial. Its primary candidate cyclodextrin drug, UDP-003, focuses on 7-ketocholesterol, an oxidized
Intermittent Fasting Improves Coordination in Mice
January 13, 2025
Researchers have discovered that intermittent fasting increases myelin in aged mice, leading to better neural function and coordination. Crucial proteins and a well-known intervention Normally, neuronal axons are coated in
Precision Targeting of Senescent Cells
January 9, 2025
In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go. Finding the right nanoparticle This paper begins with a
Restoring Cellular Proliferation Through Exosomes
January 27, 2025
In Cell Metabolism, researchers have described how a microRNA (miRNA) derived from exosomes generated by human embryonic stem cells (hESCs) restores function and fights senescence in cell cultures and mice. Looking for a better senomorphic This study begins with a discussion of cellular senescence and its
New Drug Eliminates Breast Cancer in Mouse Study
January 24, 2025
Researchers have discovered a small molecule that effectively kills cancer cells in the most prevalent type of breast cancer. The new drug could help against cancer recurrence and decrease the need for surgery [1]. The ongoing fight against breast cancer Medicine has made great strides in
Marco Quarta on Cellular Senescence in Aging
January 24, 2025
Dr. Marco Quarta runs one of the most interesting start-ups in the longevity field: Rubedo, which focuses on utilizing the senolytic approach to cellular senescence. This company has developed ingenious ways to cope with the notorious heterogeneity of senescent cells and is one of the first
Maintaining Muscle by Restoring Gut Bacteria
January 23, 2025
In Aging Cell, researchers have described how different combinations of gut bacteria impact muscle strength in mice. Expanding upon a known link The link between gut bacteria and health is well-documented, and multiple biomarkers have confirmed that a healthy gut leads to health elsewhere [1]. This
Cyclarity Launches Human Trial to Cure Atherosclerosis
January 23, 2025
Recently, Cyclarity Therapeutics announced the launch of a Phase 1 human clinical trial for a drug that aims to remove the arterial plaques that lead to heart attacks and strokes. Tackling the leading cause of death worldwide Cyclarity Therapeutics is working on a cost-effective small molecule
Maintaining Telomeres Extends Lifespan in Mice
January 22, 2025
A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, leads to lifespan extension in mice without significant side effects [1]. Protecting DNA Telomere shortening is a well-known hallmark of aging.
Fighting Alzheimer’s by Helping Neurons Consume Proteins
January 21, 2025
Researchers have found that kinesin family member 9 (KIF9), a protein that diminishes with aging, is instrumental in allowing cells to consume harmful proteins and fights Alzheimer’s in a mouse model. Consuming amyloids before they become a problem Alzheimer’s is well-known as a proteostasis disease: it
New Study Links Epigenetic Changes to Genetic Mutations
January 21, 2025
A new paper published in Nature Aging suggests that somatic mutations cause significant remodeling of the epigenetic landscape. The findings might be relevant to future anti-aging interventions [1]. The genome and the epigenome Genomic instability and epigenetic alterations are two of the hallmarks of aging [2].
The Battle for Long Life Has Been Accomplished: What’s Next?
January 20, 2025
How long can people live? This is not just a foundational question in science. The answer has important public policy implications and is of interest to us all. Recent scientific evidence has revealed the answer, so what’s next in humanity’s never-ending battle against disease and the
Enhancing NAD+ Efficiency by Energizing Sirtuins
January 16, 2025
Researchers publishing in Physical Review X have discovered compounds that can double the efficiency of the sirtuin SIRT3 in processing NAD+. Looking for a new way to boost enzymes The researchers begin their paper by noting that most drugs administered to people are geared towards inhibition
The Impact of a Human Breast Milk Probiotic on Sarcopenia
January 15, 2025
A recent study linked probiotic-induced gut microbiome and metabolite changes to improved muscle functioning in older sarcopenia patients [1]. Sarcopenia and the gut Sarcopenia is an age-related condition. People with sarcopenia suffer from a reduction in muscle mass, strength, and function, leading to a decreased quality
A Gut Metabolite Reduces Senescence and Inflammation
January 14, 2025
In a preprint study, scientists from Lifespan Research Institute and the Buck Institute for Research on Aging have published their findings that Urolithin A, a molecule that has garnered a lot of attention in the longevity field, potently reduces senescence-related markers in human fibroblasts [1]. Senolytic
Cyclarity Launches Human Trial for Atherosclerosis
January 13, 2025
Cyclarity Therapeutics, a biotechnology company based at the Buck Institute in California, has launched its first human clinical trial. Its primary candidate cyclodextrin drug, UDP-003, focuses on 7-ketocholesterol, an oxidized cholesterol variant that builds up in cells as we age. Atherosclerosis involves the accumulation of plaque
Intermittent Fasting Improves Coordination in Mice
January 13, 2025
Researchers have discovered that intermittent fasting increases myelin in aged mice, leading to better neural function and coordination. Crucial proteins and a well-known intervention Normally, neuronal axons are coated in a protein sheath made of myelin, which is necessary for their proper function [1]. Myelination is
Precision Targeting of Senescent Cells
January 9, 2025
In a journal called Small, researchers have described a new targeting mechanism for delivering senolytic compounds where they need to go. Finding the right nanoparticle This paper begins with a discussion of the well-known features of cellular senescence and laments that, despite all the work done