Category: News
A Generative, Foundational AI Model for Genetics
February 24, 2025
The Arc Institute, a nonprofit research organization, has published a manuscript on its creation of Evo 2, an AI foundation model that is capable of both understanding and building full
The Underexplored Applications of Longevity Biotechnology
February 24, 2025
No other human endeavor today holds more promise than understanding and targeting aging. The molecular mechanisms that drive aging impact overall vigor, environmental stress resistance, reproductive health, and broad disease
Young Plasma Decreases Inflammation After Surgery in Trial
February 20, 2025
In the Journal of Translational Medicine, researchers have published the results of a randomized, controlled clinical trial demonstrating that plasma proteins from young donors have beneficial effects against inflammation in
Repurposing Drugs to Lower Dementia Risk
February 19, 2025
The authors of a recent review analyzed the results of 14 studies that included 139 million people to identify patterns that connect dementia risk to commonly used medications [1]. Finding
Impressions from Hevolution’s Global Healthspan Summit 2025
February 18, 2025
These are some of the best talks from the largest healthspan conference in the world, which was held for the third time in Riyadh by the Hevolution Foundation. Young and
A Key Protein for Tendon Health
February 17, 2025
Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons. Tendons require a healthy extracellular matrix Previous
A Potential New Target for Normal Brain Aging
February 13, 2025
Yesterday in Aging Cell, researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice. Hevin vs. SPARC Astrocytes are general-purpose
Probiotics Slow Down Alzheimer’s Disease in Mice
February 12, 2025
A new study dives into a human-derived probiotic cocktail meant to protect against Alzheimer’s disease. The treatment improves gut health and reduces inflammation in mice [1]. The earlier, the better
Mitochondrial Damage May Drive Type 2 Diabetes
February 11, 2025
A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells, as well as liver and fat cells, to lose their identity and malfunction [1].
Creating a Functional Pancreas From Human Cells
February 10, 2025
In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice. A new era of organ
Some Stem Cells Remain Youthful With Age
February 6, 2025
A team of scientists has discovered that some hematopoietic stem cells (HSCs) lose their ability to differentiate into useful somatic cells and that removing those bad HSCs is beneficial. Blood
How the Yamanaka Factors Affect Female Reproduction in Rats
February 5, 2025
The authors of a recent study reported that OSKM/Yamanaka factor gene therapy in rats results in higher fertility at an older age compared to controls and allows older rats to
Early Adult Mortality Remains High in the US
February 4, 2025
Mortality among Americans aged 25-44 has risen substantially between 2011 and 2023, a new study has found, and it remains high even after having passed the COVID-related peak [1]. Riches
New Nanoparticles for Treating Arthritis
February 3, 2025
In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the
Rejuvenation Roundup January 2025
February 3, 2025
As rejuvenation research advances from theory to practice, more therapies start making their way into the clinic. 2025 continues with both mouse experiments and human clinical trials. Interviews Cyclarity Launches
A Generative, Foundational AI Model for Genetics
February 24, 2025
The Arc Institute, a nonprofit research organization, has published a manuscript on its creation of Evo 2, an AI foundation model that is capable of both understanding and building full genomes of organisms. A new step in understanding biology The authors of this paper, a group
The Underexplored Applications of Longevity Biotechnology
February 24, 2025
No other human endeavor today holds more promise than understanding and targeting aging. The molecular mechanisms that drive aging impact overall vigor, environmental stress resistance, reproductive health, and broad disease risk, and they fundamentally change what life means by radically changing our relationship to death. Intriguingly,
Young Plasma Decreases Inflammation After Surgery in Trial
February 20, 2025
In the Journal of Translational Medicine, researchers have published the results of a randomized, controlled clinical trial demonstrating that plasma proteins from young donors have beneficial effects against inflammation in a surgical context. From parabiosis experiments to the clinic It has been documented for two decades
Repurposing Drugs to Lower Dementia Risk
February 19, 2025
The authors of a recent review analyzed the results of 14 studies that included 139 million people to identify patterns that connect dementia risk to commonly used medications [1]. Finding a new purpose Despite its prevalence in the elderly population, there is a lack of effective
Impressions from Hevolution’s Global Healthspan Summit 2025
February 18, 2025
These are some of the best talks from the largest healthspan conference in the world, which was held for the third time in Riyadh by the Hevolution Foundation. Young and restless The Hevolution Foundation has only been around for three years. Before that, Saudi Arabia, its
A Key Protein for Tendon Health
February 17, 2025
Researchers publishing in Matrix Biology Plus have discovered that cochlin, a protein that decreases with age, is vital for the health of tendons. Tendons require a healthy extracellular matrix Previous work has found that tendon tissues, which link muscle to bone, require a healthy extracellular matrix
A Potential New Target for Normal Brain Aging
February 13, 2025
Yesterday in Aging Cell, researchers published their findings that using gene therapy to overexpress a synaptic promoter increases cognitive ability in ordinary, middle-aged mice. Hevin vs. SPARC Astrocytes are general-purpose helper cells of the brain, and one of their tasks is to maintain synapse structure [1].
Probiotics Slow Down Alzheimer’s Disease in Mice
February 12, 2025
A new study dives into a human-derived probiotic cocktail meant to protect against Alzheimer’s disease. The treatment improves gut health and reduces inflammation in mice [1]. The earlier, the better Early interventions to prevent or delay Alzheimer’s disease might be a more feasible approach than reversing
Mitochondrial Damage May Drive Type 2 Diabetes
February 11, 2025
A new study suggests that damaged mitochondria activate the integrated stress response, which causes pancreatic β-cells, as well as liver and fat cells, to lose their identity and malfunction [1]. Blocking this response had benefits in mouse models. The mitochondria-diabetes connection Like with many diseases, the
Creating a Functional Pancreas From Human Cells
February 10, 2025
In Cell Reports Medicine, researchers have described how they created a fully functional pancreas made from human cells and found it to work in mice. A new era of organ replacement In their introduction, the researchers discuss the well-known problems with insulin injections to treat Type
Some Stem Cells Remain Youthful With Age
February 6, 2025
A team of scientists has discovered that some hematopoietic stem cells (HSCs) lose their ability to differentiate into useful somatic cells and that removing those bad HSCs is beneficial. Blood creation diminishes with age Hematopoiesis refers to the production of blood cells, both white and red.
How the Yamanaka Factors Affect Female Reproduction in Rats
February 5, 2025
The authors of a recent study reported that OSKM/Yamanaka factor gene therapy in rats results in higher fertility at an older age compared to controls and allows older rats to have regular cycles [1]. Rejuvenating Yamanaka factors Multiple studies have suggested that gene therapy that uses
Early Adult Mortality Remains High in the US
February 4, 2025
Mortality among Americans aged 25-44 has risen substantially between 2011 and 2023, a new study has found, and it remains high even after having passed the COVID-related peak [1]. Riches to rags Despite the US being one of the world’s richest countries, Americans’ average life expectancy
New Nanoparticles for Treating Arthritis
February 3, 2025
In the Journal of Nanobiotechnology, researchers have described a new method of delivering a long-lasting treatment into cartilage. A protein that promotes autophagy Previous work has linked expression of the FGF18 protein with healthy cartilage and joints [1]. Problems with the gene responsible for FGF18 lead
Rejuvenation Roundup January 2025
February 3, 2025
As rejuvenation research advances from theory to practice, more therapies start making their way into the clinic. 2025 continues with both mouse experiments and human clinical trials. Interviews Cyclarity Launches Human Trial to Cure Atherosclerosis: Recently, Cyclarity Therapeutics announced the launch of a Phase 1 human