Category: News
Life Biosciences Is Bringing Reprogramming to the Clinic
October 29, 2024
Life Biosciences is a company co-founded by the celebrity geroscientist David Sinclair and is based on his Harvard team’s research into partial cellular reprogramming. In the heated race to translate
The Fibroblasts That Protect Ovarian Cancer
October 28, 2024
In Aging, researchers have described a subpopulation of fibroblasts that nurture ovarian cancer tumors and shield them from harm. Cancer’s natural defenders Ovarian cancer is particularly dangerous, both in death
Neuronal Reprogramming Alleviates Alzheimer’s in Mice
October 25, 2024
Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and
A Senolytic Treatment for Liver Sepsis
October 24, 2024
A paper published in Aging Cell offers evidence for the idea that senolytics might be a treatment for acute liver sepsis. A deadly condition linked to a hallmark of aging
HAPLN1 in Blood Found to Rejuvenate Skin
October 23, 2024
Investigating the factors involved in skin rejuvenation processes, researchers have identified the role of hyaluronan and proteoglycan link protein 1 (HAPLN1) in restoring collagen and hyaluronic acid in aged skin
Autodigestion From Gut Enzymes May Drive Aging
October 22, 2024
A new study links damage caused by digestive enzymes escaping from the gut to several hallmarks of aging. The researchers dubbed this effect “autodigestion.” [1] Don’t eat yourself up! To
The Reason Why the p16 Senescence Pathway Exists
October 21, 2024
Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don’t produce the senescence-related compound p16. A necessary evil The aging community has published
Scientists Create a Potent Bacterial Anti-Cancer Vaccine
October 18, 2024
A new study describes a novel anti-cancer vaccine based on antigen-producing bacteria that can tackle solid and metastatic cancers [1]. Invading an invader Years ago, scientists discovered that bacteria can
A Potential Target for Post-Surgery Cognitive Impairment
October 17, 2024
In Aging Cell, researchers have identified a receptor in the brain that appears to be responsible for cognitive problems after surgery, particularly in older people. Surgery can cause cognitive problems
Blueberry Extract Aids Cognition in People With Inflammation
October 16, 2024
A reanalysis of data from a previous study identified a difference between people with low and high levels of inflammatory biomarkers. The cognitive performance of people with high levels of
Heart Organoids Flown to Space Show Signs of Dysfunction
October 15, 2024
Scientists have found that human heart tissue is harmed by even a short stint in orbit. This might have implications for future space travel [1]. Fly me to the Moon
The Chemical Reasons Why Visceral Fat Is Dangerous
October 14, 2024
In Aging Cell, researchers have described the chemical ways in which excessive visceral fat causes oxidative stress and cellular senescence. Visceral fat is metabolically active Metabolic syndrome, a host of
Have We Maxed Out on Life Expectancy Gains?
October 11, 2024
A new study has suggested that radical life extension is all but impossible in this century [1], and it has made waves among people interested in living longer. Out of
Exosomes Break Rat Lifespan Record
October 10, 2024
In Aging Cell, researchers have published their findings that exosomes, which we have previously reported to extend the lives of mice, also extend the lives of rats. Known to be
Astragalus Supplement Lengthens Telomeres in the Middle-Aged
October 9, 2024
Treating middle-aged people for six months with a supplement combination that included astragalus, a plant used in traditional Chinese medicine, positively impacted their telomeres [1]. Preventing the shortening Telomeres are
Life Biosciences Is Bringing Reprogramming to the Clinic
October 29, 2024
Life Biosciences is a company co-founded by the celebrity geroscientist David Sinclair and is based on his Harvard team’s research into partial cellular reprogramming. In the heated race to translate this promising technology to the clinic, Life has emerged as one of the favorites, inching closer
The Fibroblasts That Protect Ovarian Cancer
October 28, 2024
In Aging, researchers have described a subpopulation of fibroblasts that nurture ovarian cancer tumors and shield them from harm. Cancer’s natural defenders Ovarian cancer is particularly dangerous, both in death rates and in recurrence [1]. Normally, chemicals that contain platinum are effective, but this sort of
Neuronal Reprogramming Alleviates Alzheimer’s in Mice
October 25, 2024
Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and space Partial cellular reprogramming is one of the hottest directions in longevity research for a reason:
A Senolytic Treatment for Liver Sepsis
October 24, 2024
A paper published in Aging Cell offers evidence for the idea that senolytics might be a treatment for acute liver sepsis. A deadly condition linked to a hallmark of aging Sepsis, an inflammatory condition most commonly known as blood poisoning, is the most common cause of
HAPLN1 in Blood Found to Rejuvenate Skin
October 23, 2024
Investigating the factors involved in skin rejuvenation processes, researchers have identified the role of hyaluronan and proteoglycan link protein 1 (HAPLN1) in restoring collagen and hyaluronic acid in aged skin [1]. The most noticeable sign of aging Skin aging, one of the most visible forms of
Autodigestion From Gut Enzymes May Drive Aging
October 22, 2024
A new study links damage caused by digestive enzymes escaping from the gut to several hallmarks of aging. The researchers dubbed this effect “autodigestion.” [1] Don’t eat yourself up! To live, we must eat, which involves breaking down compounds that we ourselves consist of, such as
The Reason Why the p16 Senescence Pathway Exists
October 21, 2024
Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don’t produce the senescence-related compound p16. A necessary evil The aging community has published a lot of papers on p16INK4a (p16) and its SASP-associated dangers, as excessive SASP production is
Scientists Create a Potent Bacterial Anti-Cancer Vaccine
October 18, 2024
A new study describes a novel anti-cancer vaccine based on antigen-producing bacteria that can tackle solid and metastatic cancers [1]. Invading an invader Years ago, scientists discovered that bacteria can colonize tumors [2]. Some bacteria are drawn to the tumor microenvironment due to factors such as
A Potential Target for Post-Surgery Cognitive Impairment
October 17, 2024
In Aging Cell, researchers have identified a receptor in the brain that appears to be responsible for cognitive problems after surgery, particularly in older people. Surgery can cause cognitive problems Neurological symptoms such as postoperative cognitive dysfunction [1] and postoperative delirium [2] are common after surgery,
Blueberry Extract Aids Cognition in People With Inflammation
October 16, 2024
A reanalysis of data from a previous study identified a difference between people with low and high levels of inflammatory biomarkers. The cognitive performance of people with high levels of inflammation improved after they consumed anthocyanin supplements [1]. Inflammation and dementia Dementia is a complex disorder
Heart Organoids Flown to Space Show Signs of Dysfunction
October 15, 2024
Scientists have found that human heart tissue is harmed by even a short stint in orbit. This might have implications for future space travel [1]. Fly me to the Moon Space exploration is cool, but the human body was obviously not made for it. All its
The Chemical Reasons Why Visceral Fat Is Dangerous
October 14, 2024
In Aging Cell, researchers have described the chemical ways in which excessive visceral fat causes oxidative stress and cellular senescence. Visceral fat is metabolically active Metabolic syndrome, a host of intertwined disorders that include obesity and cholesterol imbalance, is known to have multiple harmful effects that
Have We Maxed Out on Life Expectancy Gains?
October 11, 2024
A new study has suggested that radical life extension is all but impossible in this century [1], and it has made waves among people interested in living longer. Out of steam? A paper titled “Implausibility of radical life extension in humans in the twenty-first century” was
Exosomes Break Rat Lifespan Record
October 10, 2024
In Aging Cell, researchers have published their findings that exosomes, which we have previously reported to extend the lives of mice, also extend the lives of rats. Known to be effective Exosomes, a subset of extracellular vesicles (EVs), can be visualized as messages and packages that
Astragalus Supplement Lengthens Telomeres in the Middle-Aged
October 9, 2024
Treating middle-aged people for six months with a supplement combination that included astragalus, a plant used in traditional Chinese medicine, positively impacted their telomeres [1]. Preventing the shortening Telomeres are like shoelace aglets, forming protective caps at the ends of DNA strands. They are made of