Category: News
The Latest in Rapamycin Research on Humans
February 18, 2024
Reviewers have gone through the latest updates on studies featuring rapamycin and its derivatives in The Lancet Healthy Longevity. Testing a well-known longevity promoter Not many compounds actually extend life
New Drug Shows Promise Against Glioblastoma
February 16, 2024
Scientists have discovered a small molecule that effectively kills glioblastoma, a highly aggressive and untreatable brain cancer, in cellular cultures [1]. When acidic means deadly Despite scientists’ best efforts, some
How Aging Leads to a Gene Transcription Problem
February 15, 2024
In Nature Genetics, researchers have described how a defect in RNA transcription constitutes a previously undiscovered mechanism of aging. When the blueprint becomes harder to read Gene expression begins when
Rejuvenating Cells with Epigenetic Reprogramming
February 14, 2024
The authors of a recent review published in Ageing Research Reviews summarize the research on epigenetic reprogramming and its potential as a rejuvenation therapy [1]. Epigenetics in aging Aging leads
Mutation-Carrying CAR T Cells Eradicate Cancer in Mice
February 13, 2024
Scientists have found that giving CAR T cells a particular oncogenic mutation greatly improves their efficiency against blood and solid cancers [1]. Less than cancer One reason why cancer is
Predicting Dementia a Decade in Advance
February 12, 2024
In Nature Aging, researchers have published a method of predicting dementia over a decade before it actually occurs. Early detection was known to be possible It has been known that
Patrick Linden’s Case Against Death
February 12, 2024
People come to the longevity field from all walks of life, bringing their unique expertise along. An activist engages in advocacy and fundraising. A physicist applies theories from a specific
Reversing Senescence in Cells Using Ultrasound
February 9, 2024
A new study claims that low-frequency ultrasound can reverse aspects of replicative and chemically induced senescence in vitro [1]. Not just chemicals The age-related increase in senescent cell burden is
Exhausted Microglia Accumulate in Alzheimer’s
February 8, 2024
A recent paper published in Immunity has described the accumulation of exhausted microglia in the brains of people who are vulnerable to Alzheimer’s, potentially spurring and worsening the disease. Proteostasis
Caloric Restriction Extends Reproductive Lifespan in Hens
February 8, 2024
According to a new study, prolonged severe caloric restriction in hens, known as “molting”, restores their egg-laying capacity, slows aging, and increases survival [1]. Lay fast, die young The domestic
Chitosan Treatment Reduces Ovarian Senescence in Mice
February 7, 2024
Recent research published in Immunity and Ageing suggests that chitosan can be used as a potential treatment to alleviate some of the aging processes in ovaries [1]. Quickly declining fertility
New Combination Therapy Eradicates Cancer in Mice
February 6, 2024
Scientists have discovered a mechanism that lets senescent tumor cells undermine chemotherapy. With this mechanism blocked, standard chemotherapy led to complete regression of mammary tumors in mice [1]. Senescent yet
What Time-Restricted Eating Does and Doesn’t Affect
February 5, 2024
In Cell Reports Medicine, researchers have published a study demonstrating that, while it has no impact on many aspects of intestinal function, time-restricted eating (TRE) reduces markers of blood glucose.
Stress Impairs Gut Health via the Microbiome
February 5, 2024
A new study done in mice sheds light on how mental stress contributes to intestinal problems by altering microbiome composition [1]. Mind over matter Some experiences are not called “gut-wrenching”
Longevity and DeSci Recap – January 2024
February 2, 2024
Welcome back to the latest edition of the Longevity and DeSci Recap and the first of 2024. The past year has been packed with new discoveries and releases, including Exo’s
The Latest in Rapamycin Research on Humans
February 18, 2024
Reviewers have gone through the latest updates on studies featuring rapamycin and its derivatives in The Lancet Healthy Longevity. Testing a well-known longevity promoter Not many compounds actually extend life in healthy animals, but rapamycin is indeed one of them. These researchers report that its mechanism
New Drug Shows Promise Against Glioblastoma
February 16, 2024
Scientists have discovered a small molecule that effectively kills glioblastoma, a highly aggressive and untreatable brain cancer, in cellular cultures [1]. When acidic means deadly Despite scientists’ best efforts, some types of cancer remain almost as deadly as ever. This includes the dreaded glioblastoma, a type
How Aging Leads to a Gene Transcription Problem
February 15, 2024
In Nature Genetics, researchers have described how a defect in RNA transcription constitutes a previously undiscovered mechanism of aging. When the blueprint becomes harder to read Gene expression begins when a cell transcribes RNA from DNA protein codes. This process, like almost all others, is affected
Rejuvenating Cells with Epigenetic Reprogramming
February 14, 2024
The authors of a recent review published in Ageing Research Reviews summarize the research on epigenetic reprogramming and its potential as a rejuvenation therapy [1]. Epigenetics in aging Aging leads to changes in the epigenome. Those changes can lead to alterations in gene regulation, affecting cellular
Mutation-Carrying CAR T Cells Eradicate Cancer in Mice
February 13, 2024
Scientists have found that giving CAR T cells a particular oncogenic mutation greatly improves their efficiency against blood and solid cancers [1]. Less than cancer One reason why cancer is so dangerous is that oncogenic mutations boost cancer cells’ survivability, just like a genetically modified monster
Predicting Dementia a Decade in Advance
February 12, 2024
In Nature Aging, researchers have published a method of predicting dementia over a decade before it actually occurs. Early detection was known to be possible It has been known that it is possible to observe early signs of brain deterioration years before dementia occurs [1]. However,
Patrick Linden’s Case Against Death
February 12, 2024
People come to the longevity field from all walks of life, bringing their unique expertise along. An activist engages in advocacy and fundraising. A physicist applies theories from a specific domain of knowledge. What happens when a philosopher joins in? Naturally, that person writes a book.
Reversing Senescence in Cells Using Ultrasound
February 9, 2024
A new study claims that low-frequency ultrasound can reverse aspects of replicative and chemically induced senescence in vitro [1]. Not just chemicals The age-related increase in senescent cell burden is thought to contribute to many processes of aging. Most of the attempts to deal with it
Exhausted Microglia Accumulate in Alzheimer’s
February 8, 2024
A recent paper published in Immunity has described the accumulation of exhausted microglia in the brains of people who are vulnerable to Alzheimer’s, potentially spurring and worsening the disease. Proteostasis and inflammation Alzheimer’s is characterized by amyloids, but these misfolded protein accumulations are not its only
Caloric Restriction Extends Reproductive Lifespan in Hens
February 8, 2024
According to a new study, prolonged severe caloric restriction in hens, known as “molting”, restores their egg-laying capacity, slows aging, and increases survival [1]. Lay fast, die young The domestic hen is not the go-to animal model in aging studies, but perhaps it could offer new
Chitosan Treatment Reduces Ovarian Senescence in Mice
February 7, 2024
Recent research published in Immunity and Ageing suggests that chitosan can be used as a potential treatment to alleviate some of the aging processes in ovaries [1]. Quickly declining fertility Mother Nature has imposed some tough challenges on human females. They need to make the decision
New Combination Therapy Eradicates Cancer in Mice
February 6, 2024
Scientists have discovered a mechanism that lets senescent tumor cells undermine chemotherapy. With this mechanism blocked, standard chemotherapy led to complete regression of mammary tumors in mice [1]. Senescent yet still dangerous Chemotherapy and radiation therapy, still the two most common treatments for solid tumors, subject
What Time-Restricted Eating Does and Doesn’t Affect
February 5, 2024
In Cell Reports Medicine, researchers have published a study demonstrating that, while it has no impact on many aspects of intestinal function, time-restricted eating (TRE) reduces markers of blood glucose. A matter of when rather than what People who conduct TRE, choosing to consume food only
Stress Impairs Gut Health via the Microbiome
February 5, 2024
A new study done in mice sheds light on how mental stress contributes to intestinal problems by altering microbiome composition [1]. Mind over matter Some experiences are not called “gut-wrenching” just metaphorically, as the brain can indeed influence gastrointestinal function in a myriad of ways. While
Longevity and DeSci Recap – January 2024
February 2, 2024
Welcome back to the latest edition of the Longevity and DeSci Recap and the first of 2024. The past year has been packed with new discoveries and releases, including Exo’s Iris, a hand-held AI ultrasound device; large-scale deals, such as Fauna Bio x Lilly at $494