Category: News
Obesity Shown to Affect Brain Aging in Mice
January 12, 2023
Research published in Immunity & Ageing has shown that obesity has significant, aging-associated effects on behavior and immunity in the brains of mice. Known effects on humans and mice The
NAD+ Supplement Protects Intestines from Alcohol in Mice
January 11, 2023
Scientists have shown that the NAD+ precursor nicotinamide riboside (NR) alleviates symptoms of leaky gut caused by ethanol consumption in mice by improving mitochondrial function [1]. Leaky gut drives inflammation
The Hallmarks of Aging’s Original Authors Offer a Fresh View
January 11, 2023
The year 2023 started with the publication of two remarkable review papers in Cell and Cell Metabolism by researchers addressing the hallmarks of aging and their interplay with the hallmarks
Aubrey de Grey on LEVF and Robust Mouse Rejuvenation
January 10, 2023
Dr. Aubrey de Grey is a legend in the longevity field who has been steadfastly promoting the idea of life extension since well before it became mainstream. While with SENS
Gene Therapy to Induce Epigenetic Reprogramming
January 9, 2023
A preprint published in bioRxiv by scientists working at Rejuvenate Bio has described how gene therapy that allows for OSKM expression can be used to increase the lifespans of mice.
Silly Walking for Serious Exercise
January 6, 2023
Researchers have shown that a particular walking style that many people immediately recognize can count as high-intensity exercise [1]. Does exercise have to be boring? In the fight against aging,
Targeting Cdc42 Improves Stem Cells in Old Mice
January 5, 2023
Researchers publishing in the Nature journal npj Regenerative Medicine have zeroed in on a major reason behind stem cell exhaustion and determined that inhibiting it has significantly rejuvenative effects. A
Senescent Cells Harm Muscle Regeneration in Mice
January 4, 2023
New research published in Nature has shown that senescent cells hamper muscle regeneration through inflammation and fibrosis [1]. Cellular senescence is one of the hallmarks of aging. However, there is
Novel Longevity Gene Variants Identified in Centenarians
January 4, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain
Emma Teeling on What We Can Learn from Bats
January 3, 2023
Emma Teeling is a professor at University College of Dublin, and her research focuses on bats. In this interview, Emma explains why many bats, despite having tiny body sizes and
Rejuvenation Roundup December 2022
January 3, 2023
The holiday season is over, the new year is upon us, and we return to our mission of giving us many more years to come. Here’s what’s been done on
Changes To The Lamina Contribute To Heart Weakness
December 22, 2022
A paper just published in Nature Aging has explained how changes to the lamina contribute to heart weakness in model organisms. A protective enclosure for genetic stability Lamin proteins enclose
Transcriptome-Wide Organization Changes in Aging
December 21, 2022
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1].
Fighting Osteoporosis Through Cellular Signaling
December 19, 2022
A paper published in Experimental Gerontology has detailed how a bacterially derived compound may be useful in fighting osteoporosis. Osteoblasts and osteoclasts Osteoblasts are cells that build bone, and osteoclasts
Short Bouts of Vigorous Activity May Reduce Mortality Risk
December 16, 2022
In a study published in Nature Medicine, scientists have shown that short bouts of everyday vigorous physical activity, such as stair climbing, are associated with a considerable reduction in mortality
Obesity Shown to Affect Brain Aging in Mice
January 12, 2023
Research published in Immunity & Ageing has shown that obesity has significant, aging-associated effects on behavior and immunity in the brains of mice. Known effects on humans and mice The researchers introduce this study by discussing human studies. It is well known that obesity is a
NAD+ Supplement Protects Intestines from Alcohol in Mice
January 11, 2023
Scientists have shown that the NAD+ precursor nicotinamide riboside (NR) alleviates symptoms of leaky gut caused by ethanol consumption in mice by improving mitochondrial function [1]. Leaky gut drives inflammation The permeability of the epithelial intestinal barrier is known to increase with age. The resulting condition,
The Hallmarks of Aging’s Original Authors Offer a Fresh View
January 11, 2023
The year 2023 started with the publication of two remarkable review papers in Cell and Cell Metabolism by researchers addressing the hallmarks of aging and their interplay with the hallmarks of cancer [1,2]. These papers were authored by the same team that published the original 2013
Aubrey de Grey on LEVF and Robust Mouse Rejuvenation
January 10, 2023
Dr. Aubrey de Grey is a legend in the longevity field who has been steadfastly promoting the idea of life extension since well before it became mainstream. While with SENS Research Foundation, de Grey made significant contributions to geroscience, and at Longevity Summit Dublin last year,
Gene Therapy to Induce Epigenetic Reprogramming
January 9, 2023
A preprint published in bioRxiv by scientists working at Rejuvenate Bio has described how gene therapy that allows for OSKM expression can be used to increase the lifespans of mice. A new handle on old problems The researchers begin this study with a discussion of the
Silly Walking for Serious Exercise
January 6, 2023
Researchers have shown that a particular walking style that many people immediately recognize can count as high-intensity exercise [1]. Does exercise have to be boring? In the fight against aging, anything goes. As we have reported numerous times, exercise is one of the most effective anti-aging
Targeting Cdc42 Improves Stem Cells in Old Mice
January 5, 2023
Researchers publishing in the Nature journal npj Regenerative Medicine have zeroed in on a major reason behind stem cell exhaustion and determined that inhibiting it has significantly rejuvenative effects. A protein that suppresses stem cells In both humans and mice, the protein Cdc42 increases with aging.
Senescent Cells Harm Muscle Regeneration in Mice
January 4, 2023
New research published in Nature has shown that senescent cells hamper muscle regeneration through inflammation and fibrosis [1]. Cellular senescence is one of the hallmarks of aging. However, there is a growing understanding that, just like aging itself, senescence is a complex and heterogeneous phenomenon [2].
Novel Longevity Gene Variants Identified in Centenarians
January 4, 2023
In a study published in International Journal of Molecular Sciences, a team of researchers known for their studies on long-lived individuals has discovered four new genetic loci that partially explain extreme longevity [1]. Genetics can be friend or foe Centenarians are people who have lived for
Emma Teeling on What We Can Learn from Bats
January 3, 2023
Emma Teeling is a professor at University College of Dublin, and her research focuses on bats. In this interview, Emma explains why many bats, despite having tiny body sizes and leading very metabolically demanding lifestyles, are so amazingly long-lived. Will we ever be able to learn
Rejuvenation Roundup December 2022
January 3, 2023
The holiday season is over, the new year is upon us, and we return to our mission of giving us many more years to come. Here’s what’s been done on the rejuvenation front last month. LEAF News Team and activities Wishing You a Happy Holiday and
Changes To The Lamina Contribute To Heart Weakness
December 22, 2022
A paper just published in Nature Aging has explained how changes to the lamina contribute to heart weakness in model organisms. A protective enclosure for genetic stability Lamin proteins enclose the nucleus in the lamina, the cellular envelope that contains and protects DNA. In progeria, a
Transcriptome-Wide Organization Changes in Aging
December 21, 2022
In a new study published in Nature Aging, researchers have shown that aging is associated with a decreased expression of long transcripts over multiple tissues across several animal species [1]. Global changes It is well known that aging is accompanied by changes in the expression of
Fighting Osteoporosis Through Cellular Signaling
December 19, 2022
A paper published in Experimental Gerontology has detailed how a bacterially derived compound may be useful in fighting osteoporosis. Osteoblasts and osteoclasts Osteoblasts are cells that build bone, and osteoclasts are cells that consume it. These two processes happen consistently and naturally in the human body.
Short Bouts of Vigorous Activity May Reduce Mortality Risk
December 16, 2022
In a study published in Nature Medicine, scientists have shown that short bouts of everyday vigorous physical activity, such as stair climbing, are associated with a considerable reduction in mortality risk, especially in cardiovascular mortality [1]. Everyday activities and health Exercise is one of the most