Category: News
The Tale of One Tower: SF-Based Vertical Longevity Village
July 29, 2025
In downtown San Francisco, an entire tower is becoming a hub for longevity, AI, crypto, and robotics. It just hosted its first longevity conference. How does a group conquer a
Fighting Osteoarthritis by Targeting Fatty Acids
July 28, 2025
In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production. Fats in the wrong place Previous work
7,000 Steps a Day Are Enough for Most Benefits
July 25, 2025
A massive new meta-analysis confirms that 10,000 daily steps are not required for most of the health benefits of walking. Around 7,000 seems to be the sweet spot [1]. A
A Gene That Keeps Cells Under Control
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH),
Organ-Specific Aging Analysis Reveals Disease Connections
July 23, 2025
A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice
July 22, 2025
Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. New approaches needed Many previously discovered
Vesicles From Antler Cells Restore Bone in Monkeys
July 21, 2025
Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques. Finding the most effective EVs In
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial
July 18, 2025
Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1].
The 2025 Longevity Summit Dublin
July 15, 2025
The 2025 Longevity Summit Dublin was held in July, and we have the highlights from the event for you along with the latest research updates and news from the conference.
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice
July 15, 2025
Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood
How Blood-Brain Barrier Leaks Make Parkinson’s Worse
July 14, 2025
Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain. Failure of the
Scientists Successfully Edit Mitochondrial DNA
July 11, 2025
A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells [1]. Smaller editing tools needed Genome-editing tools such as CRISPR were
Senolytics May Affect Inflammation-Related Cognitive Decline
July 10, 2025
Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning
The Tale of One Tower: SF-Based Vertical Longevity Village
July 29, 2025
In downtown San Francisco, an entire tower is becoming a hub for longevity, AI, crypto, and robotics. It just hosted its first longevity conference. How does a group conquer a big city? The longevity community unites tens of thousands of researchers, founders, and enthusiasts, but this
Fighting Osteoarthritis by Targeting Fatty Acids
July 28, 2025
In the Cell journal iScience, researchers have published their discovery of a protein that inhibits osteoarthritis in mice by diminishing fatty acid production. Fats in the wrong place Previous work has found a strong link between obesity and osteoarthritis of the knee [1]. While the increased
7,000 Steps a Day Are Enough for Most Benefits
July 25, 2025
A massive new meta-analysis confirms that 10,000 daily steps are not required for most of the health benefits of walking. Around 7,000 seems to be the sweet spot [1]. A step in the right direction “10,000 steps a day” is some of the most frequently heard
A Gene That Keeps Cells Under Control
July 24, 2025
Researchers publishing in Cell Stem Cell have investigated the function of the gene DNMT3A and found that it has wide-ranging effects beyond methylation. More effects than expected Clonal hematopoiesis (CH), which occurs when stem cells create large numbers of cells with the same mutation, is linked
Organ-Specific Aging Analysis Reveals Disease Connections
July 23, 2025
A recent study explored the differences in the speed of organ aging. The researchers have built models that can predict the odds of diseases and mortality risk based on organ-specific proteins found in plasma [1]. Not all organs age equally Since each organ in the human
FDA-Approved Drug Combo Rescues Alzheimer’s in Mice
July 22, 2025
Scientists have creatively used large databases of existing FDA-approved drugs and electronic medical records to locate candidates that are potentially effective against Alzheimer’s [1]. New approaches needed Many previously discovered drugs may be effective beyond their original indications, but it is challenging to match them to
Vesicles From Antler Cells Restore Bone in Monkeys
July 21, 2025
Researchers publishing in Nature Aging have discovered that extracellular vesicles (EVs) derived from antler blastema progenitor cells (ABPCs) restore bone mass to rhesus macaques. Finding the most effective EVs In the world of rejuvenation research, EVs are nothing new. We have covered them extensively, as studies
AI Reveals a Hidden Effect in a Failed Alzheimer’s Trial
July 18, 2025
Scientists have created an AI model that stratifies Alzheimer’s patients into subgroups that progress slowly or rapidly. When applied to a real-world failed trial, it revealed a robust effect in the former subgroup [1]. Stratify and conquer Drugs don’t work for everyone equally. Unfortunately, clinical trials
Engineered Stem Cells Reduce Lung Fibrosis in Mice
July 17, 2025
In Molecular Therapy, researchers have described their creation of cells that express the regenerative factor GDF11 and found that they ameliorate fibrosis in a mouse model. Context-dependent benefits Like sirtuins and klotho, GDF11 is a biochemical factor that has been heavily investigated in the context of
A Hallucinogenic Mushroom Compound Extends Mouse Lifespan
July 16, 2025
Researchers investigated psilocybin, a psychedelic compound found in hallucinogenic mushrooms, for its anti-aging properties. They found that it extends cellular and organismal lifespan, even when administered later in life [1]. From ancient times to contemporary therapies Hallucinogenic mushrooms have a long history of use, reaching back
The 2025 Longevity Summit Dublin
July 15, 2025
The 2025 Longevity Summit Dublin was held in July, and we have the highlights from the event for you along with the latest research updates and news from the conference. The Summit was founded by Aubrey de Grey and Martin O’Dea in 2022 and combines a
Non-Toxic Stem Cell Transplantation Prevents Cancer in Mice
July 15, 2025
Scientists have developed a protocol for hematopoietic stem cell transplantation that reconstructs a healthy blood system and prevents blood cancers in old mice while also reducing toxicity [1]. The blood factory Hematopoietic stem cells (HSCs) work hard for our entire lives, producing vast numbers of various
How Blood-Brain Barrier Leaks Make Parkinson’s Worse
July 14, 2025
Researchers have discovered how α-synuclein (α-syn), a key protein in Parkinson’s disease and Lewy body dementia, leads to inflammation and disruption of the axons in the brain. Failure of the barrier Unlike other organs, the brain is heavily protected from many compounds in the bloodstream in
Scientists Successfully Edit Mitochondrial DNA
July 11, 2025
A new study demonstrates that novel gene-editing tools can correct disease-causing mutations in mitochondrial DNA in primary human cells [1]. Smaller editing tools needed Genome-editing tools such as CRISPR were one of the greatest scientific breakthroughs of this century. However, they are only good for editing
Senolytics May Affect Inflammation-Related Cognitive Decline
July 10, 2025
Researchers have found that inflamed, senescent microglia prune too many synapses in the hippocampus and demonstrated that a senolytic compound can ameliorate this process in Aging Cell. Some synapse pruning is normal During brain development, the resident immune cells of the brain (microglia) prune unneeded synapses