March 25, 2024
According to a paper published in Aging, a fisetin derivative that is being investigated for brain protection may also be effective in controlling glucose and ameliorating obesity. Repurposing a repurposed compound CMS121, the focus of this study, was created by modifying fisetin, a flavonol that is well known for its effects against cellular senescence. CMS121...
December 07, 2023
Scientists in the Intervention Testing Program have found that the antioxidant astaxanthin and the seasickness medication meclizine, both sold over the counter, significantly extend median lifespan in mice [1]. Astaxanthin and meclizine are in, but fisetin is out The Intervention Testing Program (ITP) has existed for about 20 years, and it is considered the gold...
September 04, 2023
A study published in Antioxidants has found that the senolytic fisetin significantly decreases cellular senescence in the brains of sheep. A flavonoid with a long history Fisetin: Benefits, Side Effects, and ResearchFisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. It is present in many trees and plants, including...
August 30, 2023
In a research paper published in GeroScience, researchers investigated the impact of senolytics on young mice and found some surprising results [1]. Senescent cell removal and other properties Senolytics, when given to older mice, clear senescent cells. Senolytics such as fisetin and quercetin also have anti-inflammatory properties and can be used as chemotherapeutics and senotherapeutics...
September 14, 2022
A study published in Aging has shown that the removal of senescent cells through senolytics alleviates muscle degeneration in a mouse model of Duchenne muscular dystrophy. A genetic disease with hallmarks of aging Duchenne muscular dystrophy is caused by a mutation that gradually destroys the muscles, eventually becoming fatal as it destroys the diaphragm or...
October 28, 2021
A team of researchers, including Dr. James Kirkland of Mayo Clinic, has published a review of the ongoing efforts of researchers to clear senescent cells through senolytics. Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...