Tag: Senotherapeutics

A study in Pharmacological Research has found that small extracellular vesicles derived from embryonic stem cells (ESC-sEVs) alleviate osteoarthritis in cells and mice. Restoring senescent cells' function Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...

New research in Aging Cell has suggested that targeting senescent cells based on their surface proteins (surfaceome) may be effective in dealing with them. Focusing on what's easiest to target Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which...

Scientific Reports has published a study that used a computational approach to identify natural senotherapeutics that have a similar impact on gene expression as a known senotherapeutic drug, dasatinib [1]. Drug combinations for better treatments Cellular senescence, a state in which cells cannot divide anymore but are still metabolically active and often display senescence-associated secretory...

The authors of a paper published in Pharmaceuticals tested multiple drug-polyphenol combinations to find the ones with the best senolytic properties [1]. Targeting senescent cells in lung diseases Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are...

Researchers publishing in the Nature journal npj aging have discovered a new peptide that might prevent cells from becoming senescent and possibly youthen human skin. Senolytics and senotherapeutics What Are Senolytics? Senotherapeutics for Senescent CellsSenolytics work by targeting one of several pro-survival pathways that senescent cells use to evade apoptosis and cling onto life. One...

Research recently published in Aging shows how senescent cells overreact to inflammatory stimuli, causing them to excessively excrete compounds that promote inflammation. The researchers hypothesize that this is one cause of the cytokine storm, an immune overreaction that is more common in the elderly and is known to cause severe dysfunction and even death when...