Tag: ApoE4

A new study suggests that the gene variant APOE4 promotes Alzheimer’s disease by increasing gliosis, but this effect can be blocked by inhibiting the protein HMGB1 [1]. The dreaded E4 While scientists still do not know the precise causes of Alzheimer’s disease or how to treat it, a person's APOE gene variant is highly predictive...

Researchers publishing in Alzheimer's and Dementia have published a correlation between the Alzheimer's-linked protein tau and another protein, bisecting N-acetylglucosamine (GlcNAc), which suggests its usefulness as a biomarker. The need for early prediction This paper begins with a note that to be effective, Alzheimer's treatment must begin before irrevocable neurodegeneration has already occurred [1]. Therefore,...

In a new study published in Nature Aging, scientists have shown that targeted ablation of neuronal APOE4, which produces the ApoE4 protein, significantly protects against Alzheimer’s disease in a mouse model [1]. The dreadful allele An infamous variant of the APOE gene, APOE4, is the strongest risk factor for late-onset Alzheimer’s disease [2]. People heterozygous...

Researchers publishing in Aging have found that there is a correlation between the APOE4 gene and poor outcomes after ischemic stroke. An allele with a long and sordid history The Relationship Between ApoE and Alzheimer'sAlzheimer's disease is the most typical form of dementia. It is a progressive disease that begins with mild memory loss, leads...

Scientists have drastically improved various symptoms of atherosclerosis in mice by precisely targeting mitochondria with a plant-derived antioxidant [1]. Age-related and deadly Atherosclerosis, the accumulation of plaques on arterial walls, is one of the deadliest age-related diseases. Atherosclerotic plaques, which consist mostly of cholesterol and fat, can impede blood flow in the artery or burst,...

Scientists have demonstrated that “the Alzheimer’s allele” APOE e4 helps cognition earlier in life prior to the onset of the disease [1]. This might point at a possible reason for some aspects of aging. What makes us stronger kills us later The risk of developing Alzheimer's, one of the deadliest age-related diseases, is considerably elevated...