Tag: mTOR

The researchers of a Nature Aging paper used multi-omics approaches to investigate cellular, molecular, and genetic drivers of human ovarian aging [1]. An early decline A decline in ovarian function occurs before a similar decline in other organs. Already in their mid-to-late thirties, women can experience symptoms such as fertility problems or increased frequency of...

Ora Biomedical and the Rapamycin Longevity Lab have launched a project to screen more than 600 mTOR inhibitors in the hope of finding some that are superior to geroscience’s poster child, rapamycin. Better than chance Rapamycin, one of the most potent compounds for prolonging lifespan in numerous animal models, was discovered serendipitously in one of...

The authors of a recent review propose that there may be positive synergistic effects from combining mTOR inhibitors and sodium-glucose co-transporter-2 (SGLT-2) inhibitors [1]. Inhibition of two molecules is better than one mTOR is a well-known molecule in aging research. Inhibition of mTOR has been shown to extend lifespan in multiple organisms, including worms, yeast,...

UCLA scientists have shown that Manuka, an exclusive honey variety, can quench estrogen receptor-positive breast cancer in vitro and in vivo [1]. Honey, kill that cancer Breast cancer remains the deadliest type of cancer in women, claiming more than 40 thousand victims a year in the US alone. Of its subtypes, estrogen receptor (ER)-positive is...

A study published in Aging Cell has reported that older people with better regulated autophagy in their skeletal muscles have less age-related frailty. Taking out the trash What is Autophagy?Autophagy, derived from ancient Greek, means "eating of self". Autophagy is the way cells break down misbehaving or nonfunctional organelles and proteins in the cell. This...

Researchers publishing in Journal of the American Veterinary Medical Association have conducted a feline clinical trial finding that rapamycin is effective against heart enlargement in cats. A well-known drug for a well-known problem Rapamycin: Benefits, Side Effects, and ResearchRapamycin is a macrolide, a class of antibiotic and it exhibits potent antitumor and immunosuppressive activity. It...