Tag: Neurons

Life Biosciences has announced that its trial of cellular reprogramming aimed at two age-related vision diseases has received a go-ahead from the FDA. We spoke with the company’s CSO to get more details. Life Biosciences, the biotech company based on Harvard professor David Sinclair’s research into cellular reprogramming, stunned everyone last year by announcing that...

Resesarchers have found that thrombospondin-1 (TSP-1), a compound that is critical in growing brain synapses, is secreted by normal astrocytes but not senescent ones. Senescence is harmful to the brain Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part;...

In Advanced Science, a team of researchers has explained how partial cellular reprogramming through the OSKM factors restores nerve repair ability to older animals. Stress as a signal This paper focuses on Schwann cells, glial cells that are often responsible for maintaining the protective sheaths of myelin around neuronal axons and help peripheral nerves to...

Scientists have discovered a pathway behind the known effect of exercise suppressing appetite: a lactate-related metabolite that acts directly on certain neurons. Not just more calories burned It has been long known that, somewhat counterintuitively, exercise transiently suppresses appetite. Scientists suspect that this contributes to exercise-related weight loss. However, the exact mechanisms behind this effect,...

Researchers publishing in Aging Cell have used single-cell transcriptomics to discover new insights into how neural stem cells (NSCs) change with aging. Adults do generate neurons The adult brain does generate new neurons [1], particularly in the hippocampus, the part of the brain responsible for memory formation [2]. Neurogenesis is limited to very specific niches,...

Researchers have discovered that intermittent fasting increases myelin in aged mice, leading to better neural function and coordination. Crucial proteins and a well-known intervention Normally, neuronal axons are coated in a protein sheath made of myelin, which is necessary for their proper function [1]. Myelination is most known to be impeded by multiple sclerosis, but...