Tag: Neurons

Scientists have shown that long-term intermittent reprogramming limited to hippocampal neurons increases their fitness and improves cognitive function in a mouse model of Alzheimer’s disease [1]. Targeted in time and space Partial cellular reprogramming is one of the hottest directions in longevity research for a reason: it allows to rejuvenate cells without driving them all...

In Aging Cell, researchers have identified a receptor in the brain that appears to be responsible for cognitive problems after surgery, particularly in older people. Surgery can cause cognitive problems Neurological symptoms such as postoperative cognitive dysfunction [1] and postoperative delirium [2] are common after surgery, particularly when the surgery is intensive or the patient...

Scientists have found that partial cellular reprogramming, both full-body and restricted to specific brain regions, rescues neurogenesis in the brains of old mice [1]. Cells going back in time Yamanaka Factors - Opportunities for RejuvenationDrs. Takahashi and Yamanaka showed that they could use Oct4, Sox2, Klf4, and c-Myc (OSKM) to reprogram cells back to pluripotent, embryonic...

In Cell, researchers have published a paper outlining the different ways in which brain cells slowly mutate with aging. The genomic damage of aging Cells accumulate mutations with aging, including brain cells [1]. However, as these researchers note, most previous research into these mutations has been on neurons rather than the glia, the helper cells...

A study published in Cell Reports has shown how the activation of a common protein in neurons improves memory in both worms and mammals. Common between animals This paper begins with a striking fact: C.elegans worms, mice, and people all lose memory with age [1] and for at least one of the same reasons: the...

Scientists publishing in Nature have explained a key pathway that leads to immune dysfunction and neurodegeneration in aging. Feeling the STING Throughout this paper, the researchers cite other papers demonstrating a cause-and-effect relationship between initial damage and long-term effects. Perturbed mitochondria release their mitochondrial DNA (mtDNA) into the internal liquid (cytosol) of microglia, the helper...