Tag: RNA

In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of synthetic cells for various research, diagnostic, and therapeutic applications [1]. Paperless origami DNA and RNA molecules are central to life, carrying essential genetic information for...

Some longevity biotech companies fit neatly into one of the big buckets we have in this field, like senolytics or cellular reprogramming. Others, such as Junevity, a small spin-out from the University of California, San Francisco, dare to walk an unbeaten path. Junevity pursues the ambitious goal of fixing age-related transcriptional dysregulation using short interfering...

Amyotrophic lateral sclerosis (ALS) only affects a fraction of cells and must be treated with high specificity. Scientists have achieved that by targeting mRNA sites associated with the disease [1]. Cryptic behavior ALS is a neurodegenerative disease in which age is a major factor. While it can be diagnosed at almost any age, the average...

In Aging Cell, researchers have published a potential method of ameliorating disc degeneration that focuses on the cells living in a low-oxygen environment within the discs. Living on low oxygen Yesterday, we discussed how an antioxidant compound was found to alleviate intervertebral disk degeneration (IVDD). This related paper focuses on a tissue that is already...

In Nature Genetics, researchers have described how a defect in RNA transcription constitutes a previously undiscovered mechanism of aging. When the blueprint becomes harder to read Gene expression begins when a cell transcribes RNA from DNA protein codes. This process, like almost all others, is affected by aging. One key reason behind this is, of...

A paper published in Aging explains the relationship of long noncoding RNAs, which change with aging, to age-related macular degeneration (AMD). A disease of deposits and aging This paper begins with a discussion of AMD and its prevalence. AMD is the most common cause of vision loss in people over 70 years old [1]. Its...