Tag: Cancer

In Aging Cell, a research team has explained why barrier cells in the human bladder are largely senescent and what might lead them to become cancerous. Targeting the right cells It is well-known that people develop urinary problems with advanced age, including increasing frequency and incontinence [1]. However, previous efforts to treat this problem have...

Researchers publishing in Nature have reported a new advance in developing chimeric antigen receptor (CAR) T cells to fight solid tumors in the brain. A difficult endeavor CAR T cell-based therapies are normally discussed in the context of blood cancers, as getting them to effectively attack solid tumors has proven very difficult, despite intensive research...

In Aging, researchers have described a subpopulation of fibroblasts that nurture ovarian cancer tumors and shield them from harm. Cancer's natural defenders Ovarian cancer is particularly dangerous, both in death rates and in recurrence [1]. Normally, chemicals that contain platinum are effective, but this sort of cancer develops resistance to such treatments; after that, prognoses...

Researchers publishing in Aging Cell have investigated the biology of skin cells taken from people who don't produce the senescence-related compound p16. A necessary evil Why we Age: Cellular SenescenceAs your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they...

A new study describes a novel anti-cancer vaccine based on antigen-producing bacteria that can tackle solid and metastatic cancers [1]. Invading an invader Years ago, scientists discovered that bacteria can colonize tumors [2]. Some bacteria are drawn to the tumor microenvironment due to factors such as necrotic tissue, hypoxia, and nutrient availability. For example, Clostridium...

A research paper published in Aging explored a link between breast cancer, hematopoietic cell transplants (HCTs), an increase in physical frailty, and cellular senescence. Treatment comes at a cost HCTs and breast cancer treatment are lifesaving procedures. However, chemotherapy in breast cancer sharply increases p16INK4a, a key biomarker of cellular senescence [1], and HCTs are...