Category: News
Need for Cholesterol May Explain Alzheimer’s Brain Patterns
March 28, 2025
Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts
Researchers Find New Target for Spinal Disc Degeneration
March 27, 2025
Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known
Heat May Speed Up Epigenetic Aging in Older Adults
March 26, 2025
A recent study reported significant associations between increased heat days and accelerated epigenetic aging [1]. Heat alters DNA While warm summer days on the beach are pleasant, extreme heat is
Anti-Amyloid Drug Reduces Alzheimer’s Risk in Small Subgroup
March 25, 2025
According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is
Joshua “Scotch” McClure: “Infectious Disease Drives Aging”
March 24, 2025
Like many people, I’m both wary of and intrigued by people who make bombastic claims. Years in the longevity field have taught me caution but also that big claims are
Scientists Create Cytoskeleton-Like Structures From RNA
March 21, 2025
In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of
A Core Senescence Biomarker Fights Inflammation
March 20, 2025
Researchers publishing in Nature Communications have found that p53, a biomarker and inducer of senescence, suppresses both inflammation and DNA damage in senescent cells. Senescence against cancer One of the
A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of
Short-Term Overeating Alters Brain Insulin Sensitivity
March 18, 2025
A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in
Elamipretide, a Potential New Drug, Reduces Frailty in Mice
March 17, 2025
In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to
Using a Surface Biomarker to Target Senescent Cells
March 14, 2025
Scientists have identified a senescence-associated surface protein that can be targeted using antibodies [1]. This discovery might help distinguish between beneficial and harmful senescent cells and could speed up the development
Cellular Senescence Prevents Unlearning in Some Male Mice
March 13, 2025
In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. Resilience versus decline The authors begin their paper by noting that cognitive
How Life Expectancy Has Changed in Europe
March 12, 2025
A recent country-level analysis of life expectancy among several European nations shows changes in life expectancy trends and how well-designed national policies can reduce or minimize exposure to risk factors,
A New Study Claims to Challenge Peto’s Paradox
March 11, 2025
Applying statistical methods to a large dataset spanning almost 300 species, scientists found a positive correlation between body size and cancer prevalence [1]. Other researchers dispute that these findings invalidate
An Existing Diabetes Drug May Treat Aspects of Aging
March 10, 2025
In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence
Need for Cholesterol May Explain Alzheimer’s Brain Patterns
March 28, 2025
Some brain regions are more vulnerable to Alzheimer’s disease than others. A new study suggests that this might be due to how they uptake cholesterol [1]. Why do some parts of the brain succumb earlier? Despite decades of research and vast amounts of funding, scientists still
Researchers Find New Target for Spinal Disc Degeneration
March 27, 2025
Researchers have found a new avenue for approaching spinal disc degeneration and published their work in Aging Cell. A very common problem Back problems in the elderly are widely known to be caused by a deteriorating spine. Some of these problems are due to the vertebrae
Heat May Speed Up Epigenetic Aging in Older Adults
March 26, 2025
A recent study reported significant associations between increased heat days and accelerated epigenetic aging [1]. Heat alters DNA While warm summer days on the beach are pleasant, extreme heat is not as enjoyable, especially in daily life. It is also not healthy, since extreme heat has
Anti-Amyloid Drug Reduces Alzheimer’s Risk in Small Subgroup
March 25, 2025
According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants [1]. Is it about amyloid beta? Despite billions of dollars invested in developing therapies against Alzheimer’s disease, the
Joshua “Scotch” McClure: “Infectious Disease Drives Aging”
March 24, 2025
Like many people, I’m both wary of and intrigued by people who make bombastic claims. Years in the longevity field have taught me caution but also that big claims are not necessarily outlandish, and few people make bigger claims than Joshua “Scotch” McClure, founder and CEO
Scientists Create Cytoskeleton-Like Structures From RNA
March 21, 2025
In a new study, researchers report producing self-assembling nanotubes and rings made from RNA molecules inside artificial cell-like lipid vesicles. In the future, this technology could facilitate the creation of synthetic cells for various research, diagnostic, and therapeutic applications [1]. Paperless origami DNA and RNA molecules
A Core Senescence Biomarker Fights Inflammation
March 20, 2025
Researchers publishing in Nature Communications have found that p53, a biomarker and inducer of senescence, suppresses both inflammation and DNA damage in senescent cells. Senescence against cancer One of the main reasons why cells become senescent is to prevent cancer. The senescence-inducing compound p53, in particular,
A Hypothalamus Neuropeptide Reduces Aging in a Mouse Model
March 19, 2025
Researchers have improved multiple health metrics in prematurely aged mice by re-establishing the production of neuropeptide Y in the hypothalamus [1]. An essential protein Age-related decline in the function of the hypothalamus, a core region of the brain, has been suggested to be a “key factor
Short-Term Overeating Alters Brain Insulin Sensitivity
March 18, 2025
A new study published in Nature Metabolism suggests that even a short period of eating loads of sweet and fatty snacks can cause brain changes reminiscent of those seen in obesity and type 2 diabetes [1]. What can go wrong in five days? If you usually
Elamipretide, a Potential New Drug, Reduces Frailty in Mice
March 17, 2025
In Aging Cell, Dr. Vadim Gladyshev and a team of researchers have described how elamipretide beneficially affects mitochondrial pathways and reverses frailty in mice. A drug on its way to the clinic As a mitochondria-affecting antioxidant peptide, elamipretide has been, and continues to be, the subject
Using a Surface Biomarker to Target Senescent Cells
March 14, 2025
Scientists have identified a senescence-associated surface protein that can be targeted using antibodies [1]. This discovery might help distinguish between beneficial and harmful senescent cells and could speed up the development of senolytic therapies. This work was done by the Lifespan Research Institute, which was formed last
Cellular Senescence Prevents Unlearning in Some Male Mice
March 13, 2025
In Aging Cell, researchers have established a link between cellular senescence and cognitive decline in unmodified male mice. Resilience versus decline The authors begin their paper by noting that cognitive decline in older people varies greatly. Some people suffer serious cognitive defects; other people are scarcely
How Life Expectancy Has Changed in Europe
March 12, 2025
A recent country-level analysis of life expectancy among several European nations shows changes in life expectancy trends and how well-designed national policies can reduce or minimize exposure to risk factors, thus improving life expectancy [1]. Slowdown in life expectancy increase Life expectancy has grown in high-income
A New Study Claims to Challenge Peto’s Paradox
March 11, 2025
Applying statistical methods to a large dataset spanning almost 300 species, scientists found a positive correlation between body size and cancer prevalence [1]. Other researchers dispute that these findings invalidate the famous paradox. A paradox of size Cancer has forever been a mortal enemy of multicellular
An Existing Diabetes Drug May Treat Aspects of Aging
March 10, 2025
In the Nature publication Signal Transduction and Targeted Therapy, researchers have described how glibenclamide, a drug used to treat type 2 diabetes, partially reverses epigenetic alterations and fights cellular senescence in mice. A system tightly tied together This paper begins with a discussion of the relationship