Month: February 2026

[Mountain View, September 17, 2025] — Lifespan Research Institute (LRI) today announced the launch of the Public Longevity Group (PLG), a new initiative focused on bridging the cultural gap between scientific breakthroughs in aging and their public acceptance. To kickstart its work, PLG has opened a crowdfunding campaign to develop tools that measure and strengthen...

Cellular reprogramming is one of the technologies most associated with longevity. The field was created in 2006, when Shinya Yamanaka showed that a cocktail of four transcription factors, commonly known as OSKM, can cause de-differentiation and massive rejuvenation of a cell, creating an iPSC (induced pluripotent stem cell). About a decade later, partial reprogramming was...

Researchers publishing in the Nature journal Cell Discovery have described how the age-related attenuation of a key metabolic axis causes human adipose-derived stem cells (hASCs) to lose functional capabilities. Pinpointing the loss of function This paper begins by highlighting a core problem of using self-derived (autologous) stem cells for treatments in older people: the cells...

João Pedro de Magalhães, professor at the University of Birmingham, is known as a prominent geroscientist who has been in the field forever, enriching it with top-tier research. He is also a skilled longevity advocate who has long taken interest in the ethics of longevity, first offering his perspective as far back as 2003. Prof....

An analysis of over 800,000 women found no association between menopausal hormone therapy and increased mortality [1]. A controversial therapy One of the first major changes that women undergo as they age is menopause, which usually occurs between 45 and 55 years of age. Menopause not only marks the end of reproduction, the hormonal changes...

Scientists have discovered that, like brown fat, white fat has a mechanism that burns fuel to produce heat. This effect could potentially be used to create weight loss drugs [1]. Central heating Cells use energy to power various cellular processes, with heat being a byproduct. However, we might need additional heat to survive. Brown adipocytes...

In Aging Cell, researchers have explained how the sirtuin SIRT6 protects against proteostasis-related brain disorders by maintaining the function of nucleoli and limiting protein production. The nucleus and nucleoli Loss of ProteostasisThe loss of proteostasis is the failure of the protein-building machinery of the cell and the accumulation of misfolded proteins, which is one of...